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Article: The cytotoxic effects of lipidic formulated gold porphyrin nanoparticles for the treatment of neuroblastoma

TitleThe cytotoxic effects of lipidic formulated gold porphyrin nanoparticles for the treatment of neuroblastoma
Authors
KeywordsGold porphyrin
Lipidic formulation
Nanoparticles
Neuroblastoma
Issue Date2010
PublisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/nanotechnology-science-and-applications-journal
Citation
Nanotechnology, Science And Applications, 2010, v. 3 n. 1, p. 23-28 How to Cite?
AbstractObjective: Nanotechnology has been identified as a promising platform in the improvement of the design and development of drug delivery systems. In the present study we investigated the potential of lipidic nanoparticles consisting of gold porphyrin for the treatment of neuroblastoma. Materials and methods: To characterize the size of the lipidic gold porphyrin nanoparticles, we used transmission electron microscopy (TEM). The in vitro cytotoxic effect on neuroblastoma activity was examined using XTT cell proliferation assay, then IC50 values were calculated. In vivo safety and toxicity were studied using intraperitoneal injection of gold porphyrin nanoparticles into normal animals. Finally, tumor size measurement and animal survival were studied to investigate the therapeutic effect of lipidic gold porphyrin nanoparticles on neuroblastoma growth. Results: We found that incorporation of gold porphyrin into lipidic nanoparticles resulted in a 16-fold increase in size. Subsequent in vitro and in vivo cytotoxicity studies further showed that the lipidic gold porphyrin nanoparticles could decrease systemic toxicity, as well as inhibiting tumor growth following administration into the neuroblastoma bearing mice. Conclusion: The delivery of lipidic gold porphyrin nanoparticles by incorporation with lipidic formulation is feasible approach to treat neuroblastoma. We await further studies to evaluate tumor killing kinetics. © 2010 Lee et al, publisher and licensee Dove Medical Press Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/92240
ISSN
2015 SCImago Journal Rankings: 2.078
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, Pen_HK
dc.contributor.authorZhu, Yen_HK
dc.contributor.authorYan, JJen_HK
dc.contributor.authorSun, RWYen_HK
dc.contributor.authorHao, Wen_HK
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorWong, KKYen_HK
dc.date.accessioned2010-09-17T10:40:13Z-
dc.date.available2010-09-17T10:40:13Z-
dc.date.issued2010en_HK
dc.identifier.citationNanotechnology, Science And Applications, 2010, v. 3 n. 1, p. 23-28en_HK
dc.identifier.issn1177-8903en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92240-
dc.description.abstractObjective: Nanotechnology has been identified as a promising platform in the improvement of the design and development of drug delivery systems. In the present study we investigated the potential of lipidic nanoparticles consisting of gold porphyrin for the treatment of neuroblastoma. Materials and methods: To characterize the size of the lipidic gold porphyrin nanoparticles, we used transmission electron microscopy (TEM). The in vitro cytotoxic effect on neuroblastoma activity was examined using XTT cell proliferation assay, then IC50 values were calculated. In vivo safety and toxicity were studied using intraperitoneal injection of gold porphyrin nanoparticles into normal animals. Finally, tumor size measurement and animal survival were studied to investigate the therapeutic effect of lipidic gold porphyrin nanoparticles on neuroblastoma growth. Results: We found that incorporation of gold porphyrin into lipidic nanoparticles resulted in a 16-fold increase in size. Subsequent in vitro and in vivo cytotoxicity studies further showed that the lipidic gold porphyrin nanoparticles could decrease systemic toxicity, as well as inhibiting tumor growth following administration into the neuroblastoma bearing mice. Conclusion: The delivery of lipidic gold porphyrin nanoparticles by incorporation with lipidic formulation is feasible approach to treat neuroblastoma. We await further studies to evaluate tumor killing kinetics. © 2010 Lee et al, publisher and licensee Dove Medical Press Ltd.en_HK
dc.languageengen_HK
dc.publisherDove Medical Press Ltd. The Journal's web site is located at http://www.dovepress.com/nanotechnology-science-and-applications-journalen_HK
dc.relation.ispartofNanotechnology, Science and Applicationsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectGold porphyrinen_HK
dc.subjectLipidic formulationen_HK
dc.subjectNanoparticlesen_HK
dc.subjectNeuroblastomaen_HK
dc.titleThe cytotoxic effects of lipidic formulated gold porphyrin nanoparticles for the treatment of neuroblastomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1177-8903&volume=3&spage=23&epage=28&date=2010&atitle=The+cytotoxic+effects+of+lipidic+formulated+gold+porphyrin+nanoparticles+for+the+treatment+of+neuroblastoma-
dc.identifier.emailSun, RWY: rwysun@hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.emailWong, KKY: kkywong@hkucc.hku.hken_HK
dc.identifier.authoritySun, RWY=rp00781en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityWong, KKY=rp01392en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.pmcidPMC3781752-
dc.identifier.scopuseid_2-s2.0-77955524072en_HK
dc.identifier.hkuros173587-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77955524072&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue1en_HK
dc.identifier.spage23en_HK
dc.identifier.epage28en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLee, P=8212119000en_HK
dc.identifier.scopusauthoridZhu, Y=37082383800en_HK
dc.identifier.scopusauthoridYan, JJ=35752634300en_HK
dc.identifier.scopusauthoridSun, RWY=26325835800en_HK
dc.identifier.scopusauthoridHao, W=36455883500en_HK
dc.identifier.scopusauthoridLiu, X=36106291400en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridWong, KKY=24438686400en_HK

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