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Article: Further evidence of the anti-inflammatory effects of silver nanoparticles
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TitleFurther evidence of the anti-inflammatory effects of silver nanoparticles
 
AuthorsWong, KKY1
Cheung, SOF1
Huang, L1
Niu, J1
Tao, C1
Ho, CM1
Che, CM1
Tam, PKH1
 
KeywordsInflammation
Nanoparticles
Silver
Toxicity
 
Issue Date2009
 
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305
 
CitationChemmedchem, 2009, v. 4 n. 7, p. 1129-1135 [How to Cite?]
DOI: http://dx.doi.org/10.1002/cmdc.200900049
 
AbstractWith the advent of nanoscience, pure silver can now be made into nanometer-sized particles. As a result, we are able to explore the potentially beneficial properties of pure silver. In our previous study using a burn wound model in mice, we demonstrated that besides antibacterial action, silver nanoparticles (nAg) appear to have anti-inflammatory properties. Herein we further confirm the anti-inflammatory effects of nAg and explore their potential clinical application through a postoperative peritoneal adhesion model. We also elucidate the potential mechanism of action of silver. Our in vitro and in vivo experimental findings show that nAg are effective at decreasing inflammation in peritoneal adhesions without significant toxic effects. This study thus provides further evidence for and contributes to the understanding of the anti-inflammatory properties of nAg and may also give a novel therapeutic direction for the prevention of postoperative adhesions. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
 
ISSN1860-7179
2012 Impact Factor: 2.835
2012 SCImago Journal Rankings: 0.952
 
DOIhttp://dx.doi.org/10.1002/cmdc.200900049
 
ISI Accession Number IDWOS:000267893000012
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, KKY
 
dc.contributor.authorCheung, SOF
 
dc.contributor.authorHuang, L
 
dc.contributor.authorNiu, J
 
dc.contributor.authorTao, C
 
dc.contributor.authorHo, CM
 
dc.contributor.authorChe, CM
 
dc.contributor.authorTam, PKH
 
dc.date.accessioned2010-09-17T10:40:06Z
 
dc.date.available2010-09-17T10:40:06Z
 
dc.date.issued2009
 
dc.description.abstractWith the advent of nanoscience, pure silver can now be made into nanometer-sized particles. As a result, we are able to explore the potentially beneficial properties of pure silver. In our previous study using a burn wound model in mice, we demonstrated that besides antibacterial action, silver nanoparticles (nAg) appear to have anti-inflammatory properties. Herein we further confirm the anti-inflammatory effects of nAg and explore their potential clinical application through a postoperative peritoneal adhesion model. We also elucidate the potential mechanism of action of silver. Our in vitro and in vivo experimental findings show that nAg are effective at decreasing inflammation in peritoneal adhesions without significant toxic effects. This study thus provides further evidence for and contributes to the understanding of the anti-inflammatory properties of nAg and may also give a novel therapeutic direction for the prevention of postoperative adhesions. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationChemmedchem, 2009, v. 4 n. 7, p. 1129-1135 [How to Cite?]
DOI: http://dx.doi.org/10.1002/cmdc.200900049
 
dc.identifier.doihttp://dx.doi.org/10.1002/cmdc.200900049
 
dc.identifier.eissn1860-7187
 
dc.identifier.epage1135
 
dc.identifier.hkuros158465
 
dc.identifier.isiWOS:000267893000012
 
dc.identifier.issn1860-7179
2012 Impact Factor: 2.835
2012 SCImago Journal Rankings: 0.952
 
dc.identifier.issue7
 
dc.identifier.pmid19405063
 
dc.identifier.scopuseid_2-s2.0-67749142233
 
dc.identifier.spage1129
 
dc.identifier.urihttp://hdl.handle.net/10722/92236
 
dc.identifier.volume4
 
dc.languageeng
 
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305
 
dc.publisher.placeGermany
 
dc.relation.ispartofChemMedChem
 
dc.relation.referencesReferences in Scopus
 
dc.subjectInflammation
 
dc.subjectNanoparticles
 
dc.subjectSilver
 
dc.subjectToxicity
 
dc.titleFurther evidence of the anti-inflammatory effects of silver nanoparticles
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong