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Article: Further evidence of the anti-inflammatory effects of silver nanoparticles

TitleFurther evidence of the anti-inflammatory effects of silver nanoparticles
Authors
KeywordsInflammation
Nanoparticles
Silver
Toxicity
Issue Date2009
PublisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305
Citation
Chemmedchem, 2009, v. 4 n. 7, p. 1129-1135 How to Cite?
AbstractWith the advent of nanoscience, pure silver can now be made into nanometer-sized particles. As a result, we are able to explore the potentially beneficial properties of pure silver. In our previous study using a burn wound model in mice, we demonstrated that besides antibacterial action, silver nanoparticles (nAg) appear to have anti-inflammatory properties. Herein we further confirm the anti-inflammatory effects of nAg and explore their potential clinical application through a postoperative peritoneal adhesion model. We also elucidate the potential mechanism of action of silver. Our in vitro and in vivo experimental findings show that nAg are effective at decreasing inflammation in peritoneal adhesions without significant toxic effects. This study thus provides further evidence for and contributes to the understanding of the anti-inflammatory properties of nAg and may also give a novel therapeutic direction for the prevention of postoperative adhesions. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Persistent Identifierhttp://hdl.handle.net/10722/92236
ISSN
2014 Impact Factor: 2.968
2014 SCImago Journal Rankings: 0.988
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KKYen_HK
dc.contributor.authorCheung, SOFen_HK
dc.contributor.authorHuang, Len_HK
dc.contributor.authorNiu, Jen_HK
dc.contributor.authorTao, Cen_HK
dc.contributor.authorHo, CMen_HK
dc.contributor.authorChe, CMen_HK
dc.contributor.authorTam, PKHen_HK
dc.date.accessioned2010-09-17T10:40:06Z-
dc.date.available2010-09-17T10:40:06Z-
dc.date.issued2009en_HK
dc.identifier.citationChemmedchem, 2009, v. 4 n. 7, p. 1129-1135en_HK
dc.identifier.issn1860-7179en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92236-
dc.description.abstractWith the advent of nanoscience, pure silver can now be made into nanometer-sized particles. As a result, we are able to explore the potentially beneficial properties of pure silver. In our previous study using a burn wound model in mice, we demonstrated that besides antibacterial action, silver nanoparticles (nAg) appear to have anti-inflammatory properties. Herein we further confirm the anti-inflammatory effects of nAg and explore their potential clinical application through a postoperative peritoneal adhesion model. We also elucidate the potential mechanism of action of silver. Our in vitro and in vivo experimental findings show that nAg are effective at decreasing inflammation in peritoneal adhesions without significant toxic effects. This study thus provides further evidence for and contributes to the understanding of the anti-inflammatory properties of nAg and may also give a novel therapeutic direction for the prevention of postoperative adhesions. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.en_HK
dc.languageengen_HK
dc.publisherWiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305en_HK
dc.relation.ispartofChemMedChemen_HK
dc.subjectInflammationen_HK
dc.subjectNanoparticlesen_HK
dc.subjectSilveren_HK
dc.subjectToxicityen_HK
dc.titleFurther evidence of the anti-inflammatory effects of silver nanoparticlesen_HK
dc.typeArticleen_HK
dc.identifier.emailWong, KKY: kkywong@hku.hken_HK
dc.identifier.emailHo, CM: rickyho@hkucc.hku.hken_HK
dc.identifier.emailChe, CM: cmche@hku.hken_HK
dc.identifier.emailTam, PKH: paultam@hku.hken_HK
dc.identifier.authorityWong, KKY=rp01392en_HK
dc.identifier.authorityHo, CM=rp00705en_HK
dc.identifier.authorityChe, CM=rp00670en_HK
dc.identifier.authorityTam, PKH=rp00060en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/cmdc.200900049en_HK
dc.identifier.pmid19405063en_HK
dc.identifier.scopuseid_2-s2.0-67749142233en_HK
dc.identifier.hkuros158465-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67749142233&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume4en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1129en_HK
dc.identifier.epage1135en_HK
dc.identifier.eissn1860-7187-
dc.identifier.isiWOS:000267893000012-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridWong, KKY=24438686400en_HK
dc.identifier.scopusauthoridCheung, SOF=35101532700en_HK
dc.identifier.scopusauthoridHuang, L=12647222900en_HK
dc.identifier.scopusauthoridNiu, J=35102966200en_HK
dc.identifier.scopusauthoridTao, C=35103587100en_HK
dc.identifier.scopusauthoridHo, CM=12807243800en_HK
dc.identifier.scopusauthoridChe, CM=7102442791en_HK
dc.identifier.scopusauthoridTam, PKH=7202539421en_HK

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