Article: Further evidence of the anti-inflammatory effects of silver nanoparticles

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Publisher Website: 10.1002/cmdc.200900049
Scopus: eid_2-s2.0-67749142233
PMID: 19405063

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Title	Further evidence of the anti-inflammatory effects of silver nanoparticles
Authors	Wong, KKY1 Cheung, SOF1 Huang, L1 Niu, J1 Tao, C1 Ho, CM1 Che, CM1 Tam, PKH1
Keywords	Inflammation Nanoparticles Silver Toxicity
Issue Date	2009
Publisher	Wiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305
Citation	Chemmedchem, 2009, v. 4 n. 7, p. 1129-1135 [How to Cite?] DOI: http://dx.doi.org/10.1002/cmdc.200900049
Abstract	With the advent of nanoscience, pure silver can now be made into nanometer-sized particles. As a result, we are able to explore the potentially beneficial properties of pure silver. In our previous study using a burn wound model in mice, we demonstrated that besides antibacterial action, silver nanoparticles (nAg) appear to have anti-inflammatory properties. Herein we further confirm the anti-inflammatory effects of nAg and explore their potential clinical application through a postoperative peritoneal adhesion model. We also elucidate the potential mechanism of action of silver. Our in vitro and in vivo experimental findings show that nAg are effective at decreasing inflammation in peritoneal adhesions without significant toxic effects. This study thus provides further evidence for and contributes to the understanding of the anti-inflammatory properties of nAg and may also give a novel therapeutic direction for the prevention of postoperative adhesions. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
ISSN	1860-7179 2011 Impact Factor: 3.151 2011 SCImago Journal Rankings: 0.264
DOI	http://dx.doi.org/10.1002/cmdc.200900049
ISI Accession Number ID	WOS:000267893000012
References	References in Scopus

DC Field	Value
dc.contributor.author	Wong, KKY
dc.contributor.author	Cheung, SOF
dc.contributor.author	Huang, L
dc.contributor.author	Niu, J
dc.contributor.author	Tao, C
dc.contributor.author	Ho, CM
dc.contributor.author	Che, CM
dc.contributor.author	Tam, PKH
dc.date.accessioned	2010-09-17T10:40:06Z
dc.date.available	2010-09-17T10:40:06Z
dc.date.issued	2009
dc.description.abstract	With the advent of nanoscience, pure silver can now be made into nanometer-sized particles. As a result, we are able to explore the potentially beneficial properties of pure silver. In our previous study using a burn wound model in mice, we demonstrated that besides antibacterial action, silver nanoparticles (nAg) appear to have anti-inflammatory properties. Herein we further confirm the anti-inflammatory effects of nAg and explore their potential clinical application through a postoperative peritoneal adhesion model. We also elucidate the potential mechanism of action of silver. Our in vitro and in vivo experimental findings show that nAg are effective at decreasing inflammation in peritoneal adhesions without significant toxic effects. This study thus provides further evidence for and contributes to the understanding of the anti-inflammatory properties of nAg and may also give a novel therapeutic direction for the prevention of postoperative adhesions. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
dc.description.nature	link_to_subscribed_fulltext
dc.identifier.citation	Chemmedchem, 2009, v. 4 n. 7, p. 1129-1135 [How to Cite?] DOI: http://dx.doi.org/10.1002/cmdc.200900049
dc.identifier.doi	http://dx.doi.org/10.1002/cmdc.200900049
dc.identifier.eissn	1860-7187
dc.identifier.epage	1135
dc.identifier.isi	WOS:000267893000012
dc.identifier.issn	1860-7179 2011 Impact Factor: 3.151 2011 SCImago Journal Rankings: 0.264
dc.identifier.issue	7
dc.identifier.pmid	19405063
dc.identifier.scopus	eid_2-s2.0-67749142233
dc.identifier.spage	1129
dc.identifier.uri	http://hdl.handle.net/10722/92236
dc.identifier.volume	4
dc.language	eng
dc.publisher	Wiley - V C H Verlag GmbH & Co KGaA. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/110485305
dc.publisher.place	Germany
dc.relation.ispartof	ChemMedChem
dc.relation.references	References in Scopus
dc.subject	Inflammation
dc.subject	Nanoparticles
dc.subject	Silver
dc.subject	Toxicity
dc.title	Further evidence of the anti-inflammatory effects of silver nanoparticles
dc.type	Article

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Article: Further evidence of the anti-inflammatory effects of silver nanoparticles

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