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Article: Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals

TitlePlasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2009, v. 32 n. 7, p. 1278-1283 How to Cite?
AbstractOBJECTIVE - To evaluate the association between 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome in the Chinese population. RESEARCH DESIGN AND METHODS - Plasma 25(OH)D was measured in a crosssectional sample of 1,443 men and 1,819 women aged 50-70 years from Beijing and Shanghai. Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. Fasting plasma glucose, insulin, lipid profile, A1C, and inflammatory markers were measured. RESULTS - The geometric mean of plasma 25(OH)D was 40.4 nmol/l, and percentages of vitamin D deficiency [25(OH)D <50 nmol/l] and insufficiency [50 ≤ 25(OH)D <75 nmol/l] were 69.2 and 24.4%, respectively. Compared with the highest 25(OH)D quintile (≥57.7 nmol/l), the odds ratio for metabolic syndrome in the lowest quintile (≤28.7 nmol/l) was 1.52 (95% CI 1.17-1.98, Ptrend = 0.0002) after multiple adjustment. Significant inverse associations also existed between 25(OH)D and individual metabolic syndrome components plus A1C. Moreover, we observed significant inverse associations of 25(OH)D with fasting insulin and the insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) in overweight and obese individuals (BMI ≥24 kg/m2) but not in their normal-weight counterparts (test for interaction: P = 0.0363 and 0.0187 for insulin and HOMA-IR, respectively). CONCLUSIONS - Vitamin D deficiency is common in the middle-aged and elderly Chinese population, and a low 25(OH)D level is significantly associated with an increased risk of having metabolic syndrome and insulin resistance. Prospective studies and randomized clinical trials are warranted to determine the role of 25(OH)D in the development of metabolic syndrome and related metabolic diseases. © 2009 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/92229
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Chinese Academy of SciencesSIBS2008006
KSCXI-YW-02
KSCX2-YWR-73
KSCX2-YW-R-116
Ministry of Science and Technology of China2006CB503902
Shanghai-Unilever Research Development FundCH-2006-0941
Funding Information:

This study was funded by the Chief Scientist Program of Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (SIBS2008006), the Knowledge Innovation Program Project of the Chinese Academy of Sciences (KSCXI-YW-02, KSCX2-YWR-73, and KSCX2-YW-R-116), the Ministry of Science and Technology of China (973 Program, Grarn. 2006CB503902), and the Shanghai-Unilever Research Development Fund (CH-2006-0941).

References

 

DC FieldValueLanguage
dc.contributor.authorLu, Len_HK
dc.contributor.authorYu, Zen_HK
dc.contributor.authorPan, Aen_HK
dc.contributor.authorHu, FBen_HK
dc.contributor.authorFranco, OHen_HK
dc.contributor.authorLi, Hen_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorYang, Xen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorLin, Xen_HK
dc.date.accessioned2010-09-17T10:39:53Z-
dc.date.available2010-09-17T10:39:53Z-
dc.date.issued2009en_HK
dc.identifier.citationDiabetes Care, 2009, v. 32 n. 7, p. 1278-1283en_HK
dc.identifier.issn0149-5992en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92229-
dc.description.abstractOBJECTIVE - To evaluate the association between 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome in the Chinese population. RESEARCH DESIGN AND METHODS - Plasma 25(OH)D was measured in a crosssectional sample of 1,443 men and 1,819 women aged 50-70 years from Beijing and Shanghai. Metabolic syndrome was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. Fasting plasma glucose, insulin, lipid profile, A1C, and inflammatory markers were measured. RESULTS - The geometric mean of plasma 25(OH)D was 40.4 nmol/l, and percentages of vitamin D deficiency [25(OH)D <50 nmol/l] and insufficiency [50 ≤ 25(OH)D <75 nmol/l] were 69.2 and 24.4%, respectively. Compared with the highest 25(OH)D quintile (≥57.7 nmol/l), the odds ratio for metabolic syndrome in the lowest quintile (≤28.7 nmol/l) was 1.52 (95% CI 1.17-1.98, Ptrend = 0.0002) after multiple adjustment. Significant inverse associations also existed between 25(OH)D and individual metabolic syndrome components plus A1C. Moreover, we observed significant inverse associations of 25(OH)D with fasting insulin and the insulin resistance index (homeostasis model assessment of insulin resistance [HOMA-IR]) in overweight and obese individuals (BMI ≥24 kg/m2) but not in their normal-weight counterparts (test for interaction: P = 0.0363 and 0.0187 for insulin and HOMA-IR, respectively). CONCLUSIONS - Vitamin D deficiency is common in the middle-aged and elderly Chinese population, and a low 25(OH)D level is significantly associated with an increased risk of having metabolic syndrome and insulin resistance. Prospective studies and randomized clinical trials are warranted to determine the role of 25(OH)D in the development of metabolic syndrome and related metabolic diseases. © 2009 by the American Diabetes Association.en_HK
dc.languageengen_HK
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_HK
dc.relation.ispartofDiabetes Careen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titlePlasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individualsen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2337/dc09-0209en_HK
dc.identifier.pmid19366976-
dc.identifier.pmcidPMC2699709-
dc.identifier.scopuseid_2-s2.0-67650066856en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67650066856&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume32en_HK
dc.identifier.issue7en_HK
dc.identifier.spage1278en_HK
dc.identifier.epage1283en_HK
dc.identifier.eissn1935-5548-
dc.identifier.isiWOS:000267878300031-

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