Article: Fibulin 1 is downregulated through promoter hypermethylation in gastric cancer

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TitleFibulin 1 is downregulated through promoter hypermethylation in gastric cancer
AuthorsCheng, YY2
Jin, H2
Liu, X2
Siu, JMT2
Wong, YP2
Ng, EKO2
Yu, J2
Leung, WK2
Sung, JJY2
Chan, FKL1 2
KeywordsFBLN1
Gastric cancer
Methylation
Tumour suppressor gene
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
CitationBritish Journal Of Cancer, 2008, v. 99 n. 12, p. 2083-2087 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.bjc.6604760
AbstractTumour suppressor genes (TSGs) were frequently inactivated through promoter hypermethylation in gastric carcinoma as well as pre-malignant gastric lesions, suggesting that promoter hypermethylation can be used as a marker to define novel TSGs and also biomarkers for early detection of gastric cancer. In an effort to search for such genes aberrantly methylated in gastric cancer development, fibulin 1 (FBLN1) was found as a candidate TSG epigenetically downregulated in gastric cancer. FBLN1 expression was downregulated in all of gastric cancer cell lines used (100%, 7 out of 7) and the primary gastric carcinoma tissues (84%, 86 out of 102) and significantly restored after pharmacological demethylation. Hypermethylation of the FBLN1 promoter was frequently (71%, 5 out of 7) detected in gastric cancer cell lines and primary gastric carcinoma tissues. Ectopic expression of FBLN1 led to the growth inhibition of gastric cancer cells through the induction of apoptosis. In summary, FBLN1 was identified as a novel candidate TSG epigenetically downregulated in gastric cancer. © 2008 Cancer Research.
ISSN0007-0920
2011 Impact Factor: 5.042
2011 SCImago Journal Rankings: 0.561
DOIhttp://dx.doi.org/10.1038/sj.bjc.6604760
PubMed Central IDPMC2607230
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheng, YY
dc.contributor.authorJin, H
dc.contributor.authorLiu, X
dc.contributor.authorSiu, JMT
dc.contributor.authorWong, YP
dc.contributor.authorNg, EKO
dc.contributor.authorYu, J
dc.contributor.authorLeung, WK
dc.contributor.authorSung, JJY
dc.contributor.authorChan, FKL
dc.date.accessioned2010-09-17T10:39:40Z
dc.date.available2010-09-17T10:39:40Z
dc.date.issued2008
dc.description.abstractTumour suppressor genes (TSGs) were frequently inactivated through promoter hypermethylation in gastric carcinoma as well as pre-malignant gastric lesions, suggesting that promoter hypermethylation can be used as a marker to define novel TSGs and also biomarkers for early detection of gastric cancer. In an effort to search for such genes aberrantly methylated in gastric cancer development, fibulin 1 (FBLN1) was found as a candidate TSG epigenetically downregulated in gastric cancer. FBLN1 expression was downregulated in all of gastric cancer cell lines used (100%, 7 out of 7) and the primary gastric carcinoma tissues (84%, 86 out of 102) and significantly restored after pharmacological demethylation. Hypermethylation of the FBLN1 promoter was frequently (71%, 5 out of 7) detected in gastric cancer cell lines and primary gastric carcinoma tissues. Ectopic expression of FBLN1 led to the growth inhibition of gastric cancer cells through the induction of apoptosis. In summary, FBLN1 was identified as a novel candidate TSG epigenetically downregulated in gastric cancer. © 2008 Cancer Research.
dc.description.naturepublished_or_final_version
dc.identifier.citationBritish Journal Of Cancer, 2008, v. 99 n. 12, p. 2083-2087 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.bjc.6604760
dc.identifier.citeulike3481157
dc.identifier.doihttp://dx.doi.org/10.1038/sj.bjc.6604760
dc.identifier.eissn1532-1827
dc.identifier.epage2087
dc.identifier.isiWOS:000261620100016
Funding AgencyGrant Number
Research Funding from the Institute of Digestive Disease, the Chinese University of Hong Kong
Funding Information:

The project was supported by Research Funding from the Institute of Digestive Disease, the Chinese University of Hong Kong.

dc.identifier.issn0007-0920
2011 Impact Factor: 5.042
2011 SCImago Journal Rankings: 0.561
dc.identifier.issue12
dc.identifier.pmcidPMC2607230
dc.identifier.pmid18985039
dc.identifier.scopuseid_2-s2.0-57449097981
dc.identifier.spage2083
dc.identifier.urihttp://hdl.handle.net/10722/92222
dc.identifier.volume99
dc.languageeng
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
dc.publisher.placeUnited Kingdom
dc.relation.ispartofBritish Journal of Cancer
dc.relation.referencesReferences in Scopus
dc.subjectFBLN1
dc.subjectGastric cancer
dc.subjectMethylation
dc.subjectTumour suppressor gene
dc.titleFibulin 1 is downregulated through promoter hypermethylation in gastric cancer
dc.typeArticle
Author Affiliations
  1. Prince of Wales Hospital Hong Kong
  2. Chinese University of Hong Kong