Article: High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B
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- Publisher Website: 10.1002/ijc.24281
- Scopus: eid_2-s2.0-65649111667
- PMID: 19267406
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| Title | High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B | ||||||
|---|---|---|---|---|---|---|---|
| Authors | Wong, VWS2 Yu, J2 Cheng, ASL2 Wong, GLH2 Chan, HY2 Chu, ESH2 Ng, EKO2 Chan, FKL2 Sung, JJY2 Chan, HLY1 2 | ||||||
| Keywords | Case-control studies Cytokines Fibrosis Hepatitis B Interleukin-6 Liver neoplasms | ||||||
| Issue Date | 2009 | ||||||
| Publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home | ||||||
| Citation | International Journal Of Cancer, 2009, v. 124 n. 12, p. 2766-2770 [How to Cite?] DOI: http://dx.doi.org/10.1002/ijc.24281 | ||||||
| Abstract | Increased interleukin-6 (IL-6) production is implicated in the pathogenesis of hepatocellular carcinoma (HCC) in animal models. Although previous studies showed that HCC patients had higher serum IL-6 level at the time of diagnosis, it is unclear if the cytokine contributes to the development of HCC or is just a reaction to cancer. To address this question, we performed a nested case-control study. Consecutive chronic hepatitis B patients were recruited from 1997 to 2000 and followed till 2008. Profiling of 27 cytokines, chemokines and growth factors was performed at baseline, date of peak alanine aminotransferase (ALT) level and the last visit. Thirty-seven patients developed HCC at a median follow-up of 62 months (interquartile range: 41-110). Serum IL-6 was higher in patients with HCC than controls both during peak ALT and at the last visit (both p = 0.02). Patients with IL-6 above 7 pg/ml during peak ALT had increased risk of HCC or death (adjusted hazard ratio 3.0; 95% confidence interval 1.2, 7.8; p = 0.02). The sensitivity, specificity, positive and negative predictive values of this cutoff to predict future HCC development were 70%, 73%, 72% and 71%, respectively. Combination of IL-6 and AFP improved the sensitivity in diagnosing HCC or predicting future HCC development. In conclusion, high serum IL-6 level predates the development of HCC in chronic hepatitis B patients, and has moderate accuracy in predicting future cancer. This may assist clinicians in selecting high-risk patients for HCC surveillance program. © 2009 UICC. | ||||||
| ISSN | 0020-7136 2011 Impact Factor: 5.444 2011 SCImago Journal Rankings: 0.620 | ||||||
| DOI | http://dx.doi.org/10.1002/ijc.24281 | ||||||
| ISI Accession Number ID | WOS:000265997500002
Funding Information: Grant sponsors: The Chinese University of Hong Kong and the Research Fund of the Department of Medicine and Therapeutics, The Chinese University of Hong Kong; Grant number: 2007.2.018. | ||||||
| References | References in Scopus |
| dc.contributor.author | Wong, VWS | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Yu, J | ||||||
| dc.contributor.author | Cheng, ASL | ||||||
| dc.contributor.author | Wong, GLH | ||||||
| dc.contributor.author | Chan, HY | ||||||
| dc.contributor.author | Chu, ESH | ||||||
| dc.contributor.author | Ng, EKO | ||||||
| dc.contributor.author | Chan, FKL | ||||||
| dc.contributor.author | Sung, JJY | ||||||
| dc.contributor.author | Chan, HLY | ||||||
| dc.date.accessioned | 2010-09-17T10:39:07Z | ||||||
| dc.date.available | 2010-09-17T10:39:07Z | ||||||
| dc.date.issued | 2009 | ||||||
| dc.description.abstract | Increased interleukin-6 (IL-6) production is implicated in the pathogenesis of hepatocellular carcinoma (HCC) in animal models. Although previous studies showed that HCC patients had higher serum IL-6 level at the time of diagnosis, it is unclear if the cytokine contributes to the development of HCC or is just a reaction to cancer. To address this question, we performed a nested case-control study. Consecutive chronic hepatitis B patients were recruited from 1997 to 2000 and followed till 2008. Profiling of 27 cytokines, chemokines and growth factors was performed at baseline, date of peak alanine aminotransferase (ALT) level and the last visit. Thirty-seven patients developed HCC at a median follow-up of 62 months (interquartile range: 41-110). Serum IL-6 was higher in patients with HCC than controls both during peak ALT and at the last visit (both p = 0.02). Patients with IL-6 above 7 pg/ml during peak ALT had increased risk of HCC or death (adjusted hazard ratio 3.0; 95% confidence interval 1.2, 7.8; p = 0.02). The sensitivity, specificity, positive and negative predictive values of this cutoff to predict future HCC development were 70%, 73%, 72% and 71%, respectively. Combination of IL-6 and AFP improved the sensitivity in diagnosing HCC or predicting future HCC development. In conclusion, high serum IL-6 level predates the development of HCC in chronic hepatitis B patients, and has moderate accuracy in predicting future cancer. This may assist clinicians in selecting high-risk patients for HCC surveillance program. © 2009 UICC. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | International Journal Of Cancer, 2009, v. 124 n. 12, p. 2766-2770 [How to Cite?] DOI: http://dx.doi.org/10.1002/ijc.24281 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1002/ijc.24281 | ||||||
| dc.identifier.epage | 2770 | ||||||
| dc.identifier.hkuros | 168711 | ||||||
| dc.identifier.isi | WOS:000265997500002
Funding Information: Grant sponsors: The Chinese University of Hong Kong and the Research Fund of the Department of Medicine and Therapeutics, The Chinese University of Hong Kong; Grant number: 2007.2.018. | ||||||
| dc.identifier.issn | 0020-7136 2011 Impact Factor: 5.444 2011 SCImago Journal Rankings: 0.620 | ||||||
| dc.identifier.issue | 12 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 19267406 | ||||||
| dc.identifier.scopus | eid_2-s2.0-65649111667 | ||||||
| dc.identifier.spage | 2766 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/92203 | ||||||
| dc.identifier.volume | 124 | ||||||
| dc.language | eng | ||||||
| dc.publisher | John Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | International Journal of Cancer | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.rights | International Journal of Cancer. Copyright © John Wiley & Sons, Inc. | ||||||
| dc.subject.mesh | Carcinoma, Hepatocellular - blood - virology | ||||||
| dc.subject.mesh | Hepatitis B virus - isolation and purification | ||||||
| dc.subject.mesh | Hepatitis B, Chronic - blood - virology | ||||||
| dc.subject.mesh | Interleukin-6 - blood | ||||||
| dc.subject.mesh | Liver Neoplasms - blood - virology | ||||||
| dc.subject | Case-control studies | ||||||
| dc.subject | Cytokines | ||||||
| dc.subject | Fibrosis | ||||||
| dc.subject | Hepatitis B | ||||||
| dc.subject | Interleukin-6 | ||||||
| dc.subject | Liver neoplasms | ||||||
| dc.title | High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B | ||||||
| dc.type | Article |
Author Affiliations
- Prince of Wales Hospital Hong Kong
- Chinese University of Hong Kong