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Article: Study on degradation kinetics of potassium dehydroandrographolidi succinas

TitleStudy on degradation kinetics of potassium dehydroandrographolidi succinas
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2006
Citation
Journal of Sichuan University (Medical Science Edition), 2006, v. 37 n. 5, p. 794-797 How to Cite?
AbstractObjective: To investigate the hydrolytic degradation of the kinetic characteristics of Potassium Dehydroandrographolidi Succinas (DAS-K) in aqueous solution. Methods: The HPLC method was used to determine the degradation kinetic parameters of DAS-K aqueous solution at different initial concentration, different pH, different ionic strength, various temperatures and in different buffer solutions. Results: DAS-K hydrolytic degradation followed first-order kinetics as measured by HPLC. From pH 8, the hydrolytic degradation rate of DAS-K markedly increased with pH. DAS-K was unstable in alkaline pH solution. The species of buffer solutions seem to have different impact on the catalytic process. The ionic strength did not have significant effect on the stability of the drug. According to the Arrhenius plot, the dependence of the decomposition on temperature was a determining factor, the activation energy was estimated to be 95. 68 KJ/mol in phosphate buffer solution at pH 8 and temperature from 60 to 90 °C. Conclusion: It was found that the hydrolytic degradation of DAS-K complied with first-order kinetics. The rate of hydrolytic degradation of DAS-K depended on the pH of solution, the buffer concentration, the buffer species and the temperature. Especially, pH value was an important factor in determining the rate of the hydrolytic degradation of the drug.
Persistent Identifierhttp://hdl.handle.net/10722/92182
ISSN
2015 SCImago Journal Rankings: 0.140
References

 

DC FieldValueLanguage
dc.contributor.authorLuo, W-Wen_HK
dc.contributor.authorHe, Y-Jen_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorMo, Yen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorLin, L-Yen_HK
dc.contributor.authorYan, G-Qen_HK
dc.date.accessioned2010-09-17T10:38:29Z-
dc.date.available2010-09-17T10:38:29Z-
dc.date.issued2006en_HK
dc.identifier.citationJournal of Sichuan University (Medical Science Edition), 2006, v. 37 n. 5, p. 794-797en_HK
dc.identifier.issn1672-173Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/92182-
dc.description.abstractObjective: To investigate the hydrolytic degradation of the kinetic characteristics of Potassium Dehydroandrographolidi Succinas (DAS-K) in aqueous solution. Methods: The HPLC method was used to determine the degradation kinetic parameters of DAS-K aqueous solution at different initial concentration, different pH, different ionic strength, various temperatures and in different buffer solutions. Results: DAS-K hydrolytic degradation followed first-order kinetics as measured by HPLC. From pH 8, the hydrolytic degradation rate of DAS-K markedly increased with pH. DAS-K was unstable in alkaline pH solution. The species of buffer solutions seem to have different impact on the catalytic process. The ionic strength did not have significant effect on the stability of the drug. According to the Arrhenius plot, the dependence of the decomposition on temperature was a determining factor, the activation energy was estimated to be 95. 68 KJ/mol in phosphate buffer solution at pH 8 and temperature from 60 to 90 °C. Conclusion: It was found that the hydrolytic degradation of DAS-K complied with first-order kinetics. The rate of hydrolytic degradation of DAS-K depended on the pH of solution, the buffer concentration, the buffer species and the temperature. Especially, pH value was an important factor in determining the rate of the hydrolytic degradation of the drug.en_HK
dc.languageengen_HK
dc.relation.ispartofJournal of Sichuan University (Medical Science Edition)en_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleStudy on degradation kinetics of potassium dehydroandrographolidi succinasen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17037755-
dc.identifier.scopuseid_2-s2.0-33749631577en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33749631577&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue5en_HK
dc.identifier.spage794en_HK
dc.identifier.epage797en_HK

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