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Article: Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma

TitleArray-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2005
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2005, v. 65 n. 18, p. 8125-8133 How to Cite?
AbstractNasopharyegeal carcinoma is highly prevalent in Southern China and Southeast Asia. To unveil the molecular basis of this endemic disease, high-resolution comparative genomic hybridization arrays were used for systematic investigation of genomic abnormalities in 26 nasopharyngeal carcinoma samples. A comprehensive picture of genetic lesions associated with tumorigenesis of nasopharyngeal carcinoma was generated. Consistent chromosomal gains were frequently found on 1q, 3q, 8q, 11q, 12p, and 12q. High incidences of nonrandom losses were identified on chromosomes 3p, 9p, 11q, 14q, and 16q. In addition to previously characterized regions, we have identified several novel minimal regions of gains, including 3q27.3-28, 8q21-24, 11q13.1-13.3, and 12q13, which may harbor candidate nasopharyngeal carcinoma-associated oncogenes. In this study, gain of 11q13.1-13.3 was the most frequently detected chromosomal aberration and a 5.3-Mb amplicon was delineated at this region. Within this 11q13 amplicon, concordant amplification and overexpression of cyclin D1 (CCND1) oncogene was found in nasopharyngeal carcinoma cell lines, xenografts, and primary tumors. Knockdown of cyclin D1 by small interfering RNA in nasopharyngeal carcinoma cell lines led to significant decrease of cell proliferation. The findings suggest that cyclin D1 is a target oncogene at 11q13 in nasopharyngeal carcinoma and its activation plays a significant role in nasopharyngeal carcinoma tumorigenesis. ©2005 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/92141
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, ABYen_HK
dc.contributor.authorOr, YYYen_HK
dc.contributor.authorTakano, Hen_HK
dc.contributor.authorTsang, RKYen_HK
dc.contributor.authorTo, KFen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorSham, JSTen_HK
dc.contributor.authorHung, KWKen_HK
dc.contributor.authorLam, CNYen_HK
dc.contributor.authorVan Hasselt, CAen_HK
dc.contributor.authorKuo, WLen_HK
dc.contributor.authorGray, JWen_HK
dc.contributor.authorHuang, DPen_HK
dc.contributor.authorLo, KWen_HK
dc.date.accessioned2010-09-17T10:37:17Z-
dc.date.available2010-09-17T10:37:17Z-
dc.date.issued2005en_HK
dc.identifier.citationCancer Research, 2005, v. 65 n. 18, p. 8125-8133en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92141-
dc.description.abstractNasopharyegeal carcinoma is highly prevalent in Southern China and Southeast Asia. To unveil the molecular basis of this endemic disease, high-resolution comparative genomic hybridization arrays were used for systematic investigation of genomic abnormalities in 26 nasopharyngeal carcinoma samples. A comprehensive picture of genetic lesions associated with tumorigenesis of nasopharyngeal carcinoma was generated. Consistent chromosomal gains were frequently found on 1q, 3q, 8q, 11q, 12p, and 12q. High incidences of nonrandom losses were identified on chromosomes 3p, 9p, 11q, 14q, and 16q. In addition to previously characterized regions, we have identified several novel minimal regions of gains, including 3q27.3-28, 8q21-24, 11q13.1-13.3, and 12q13, which may harbor candidate nasopharyngeal carcinoma-associated oncogenes. In this study, gain of 11q13.1-13.3 was the most frequently detected chromosomal aberration and a 5.3-Mb amplicon was delineated at this region. Within this 11q13 amplicon, concordant amplification and overexpression of cyclin D1 (CCND1) oncogene was found in nasopharyngeal carcinoma cell lines, xenografts, and primary tumors. Knockdown of cyclin D1 by small interfering RNA in nasopharyngeal carcinoma cell lines led to significant decrease of cell proliferation. The findings suggest that cyclin D1 is a target oncogene at 11q13 in nasopharyngeal carcinoma and its activation plays a significant role in nasopharyngeal carcinoma tumorigenesis. ©2005 American Association for Cancer Research.en_HK
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCell Line, Tumoren_HK
dc.subject.meshChromosome Deletionen_HK
dc.subject.meshChromosomes, Human, Pair 11 - geneticsen_HK
dc.subject.meshGene Amplificationen_HK
dc.subject.meshGenes, bcl-1 - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMiceen_HK
dc.subject.meshNasopharyngeal Neoplasms - geneticsen_HK
dc.subject.meshNucleic Acid Hybridizationen_HK
dc.subject.meshRNA, Small Interfering - geneticsen_HK
dc.subject.meshTransfectionen_HK
dc.subject.meshTransplantation, Heterologousen_HK
dc.titleArray-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailTsang, RKY:rkytsang@hku.hken_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.authorityTsang, RKY=rp01386en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1158/0008-5472.CAN-05-0648en_HK
dc.identifier.pmid16166286-
dc.identifier.scopuseid_2-s2.0-24944545948en_HK
dc.identifier.hkuros119623-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24944545948&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume65en_HK
dc.identifier.issue18en_HK
dc.identifier.spage8125en_HK
dc.identifier.epage8133en_HK
dc.identifier.isiWOS:000231848800011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHui, ABY=7102453683en_HK
dc.identifier.scopusauthoridOr, YYY=8940434900en_HK
dc.identifier.scopusauthoridTakano, H=7401826367en_HK
dc.identifier.scopusauthoridTsang, RKY=7102940058en_HK
dc.identifier.scopusauthoridTo, KF=7101911940en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridSham, JST=24472255400en_HK
dc.identifier.scopusauthoridHung, KWK=8940435500en_HK
dc.identifier.scopusauthoridLam, CNY=8940435600en_HK
dc.identifier.scopusauthoridVan Hasselt, CA=7103394173en_HK
dc.identifier.scopusauthoridKuo, WL=7202113195en_HK
dc.identifier.scopusauthoridGray, JW=7404300313en_HK
dc.identifier.scopusauthoridHuang, DP=7403891486en_HK
dc.identifier.scopusauthoridLo, KW=34872774800en_HK

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