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Article: Deguelin represses both the expression of nucleophosmin and some nucleoporins: Nup88 and Nup214 in Jurkat cells

TitleDeguelin represses both the expression of nucleophosmin and some nucleoporins: Nup88 and Nup214 in Jurkat cells
Authors
KeywordsMolecular Sequence Numbers
Issue Date2008
PublisherPharmaceutical Society of Japan. The Journal's web site is located at http://bpb.pharm.or.jp/index.html
Citation
Biological and Pharmaceutical Bulletin, 2008, v. 31 n. 1, p. 27-32 How to Cite?
AbstractSince the first report about cytoplasmic nucleophosmin (NPM) in acute myelogenous leukemia with a normal karyotype was announced, the shuttling activity of NPM and its proper subcellular localization have drawn many attentions. Mechanisms that regulate nucleocytoplasmic transport of proteins may provide novel opportunities for drug development. Here we show that, in Jurkat cells, strong fluorescence density of NPM prevails in the nucleus, while, some key nucleoporins: Nup88 and Nup214 localize mainly in the cytoplasm. Deguelin, a natural occurring rotenoid, presents powerful anti-leukemia effects through proliferation inhibition and apoptosis induction in Jurkat cells. Deguelin downregulates the expression of NPM, Nup88 and Nup214 in a dose-dependent manner and reverts the localization of Nup88 and Nup214 to nuclear rim. These results suggest that deguelin exhibit its strong anti-leukemia effects might through the regulation of some nucleoporins, thus influence the subsequent abnormal expressions or localizations of some key proteins involved in proliferation and/or apoptosis, such as: NPM. © 2008 Pharmaceutical Society of Japan.
Persistent Identifierhttp://hdl.handle.net/10722/92120
ISSN
2015 Impact Factor: 1.574
2015 SCImago Journal Rankings: 0.644
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShu, Wen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorWu, Qen_HK
dc.contributor.authorLi, Ren_HK
dc.contributor.authorCui, Gen_HK
dc.date.accessioned2010-09-17T10:36:40Z-
dc.date.available2010-09-17T10:36:40Z-
dc.date.issued2008en_HK
dc.identifier.citationBiological and Pharmaceutical Bulletin, 2008, v. 31 n. 1, p. 27-32en_HK
dc.identifier.issn0918-6158en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92120-
dc.description.abstractSince the first report about cytoplasmic nucleophosmin (NPM) in acute myelogenous leukemia with a normal karyotype was announced, the shuttling activity of NPM and its proper subcellular localization have drawn many attentions. Mechanisms that regulate nucleocytoplasmic transport of proteins may provide novel opportunities for drug development. Here we show that, in Jurkat cells, strong fluorescence density of NPM prevails in the nucleus, while, some key nucleoporins: Nup88 and Nup214 localize mainly in the cytoplasm. Deguelin, a natural occurring rotenoid, presents powerful anti-leukemia effects through proliferation inhibition and apoptosis induction in Jurkat cells. Deguelin downregulates the expression of NPM, Nup88 and Nup214 in a dose-dependent manner and reverts the localization of Nup88 and Nup214 to nuclear rim. These results suggest that deguelin exhibit its strong anti-leukemia effects might through the regulation of some nucleoporins, thus influence the subsequent abnormal expressions or localizations of some key proteins involved in proliferation and/or apoptosis, such as: NPM. © 2008 Pharmaceutical Society of Japan.en_HK
dc.languageengen_HK
dc.publisherPharmaceutical Society of Japan. The Journal's web site is located at http://bpb.pharm.or.jp/index.htmlen_HK
dc.relation.ispartofBiological and Pharmaceutical Bulletinen_HK
dc.subjectMolecular Sequence Numbersen_HK
dc.titleDeguelin represses both the expression of nucleophosmin and some nucleoporins: Nup88 and Nup214 in Jurkat cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1248/bpb.31.27en_HK
dc.identifier.pmid18175937-
dc.identifier.scopuseid_2-s2.0-37849051674en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37849051674&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue1en_HK
dc.identifier.spage27en_HK
dc.identifier.epage32en_HK
dc.identifier.eissn1347-5215-
dc.identifier.isiWOS:000252915400005-

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