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Article: Effects of Panax notoginseng saponins on rat cardiomyocytes apoptosis induced by angiotengin II in vitro

TitleEffects of Panax notoginseng saponins on rat cardiomyocytes apoptosis induced by angiotengin II in vitro
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2005
PublisherZhongguo Zhongyao Zazhishe. The Journal's web site is located at http://zgzyzz.periodicals.net.cn/
Citation
Zhongguo Zhongyao Zazhi, 2005, v. 30 n. 10, p. 778-781 How to Cite?
AbstractObjective: To study the protective effects of Panax notoginseng saponins(PNS) on angiotensin II (Ang II)-induced rat cardiomyocyte apoptosis in vitro and the probable mechanism. Method: Cultured cardiomyocytes from neonatal rats were stimulated with Ang II. Cell viability was measured by MTT. Apoptosis was evaluated using Acridine Orange(AO) fluorescent dye staining and flow cytometry; Fluo-3 AM was used to test the change of intracellular free calcium. Result: It was found that incubating with Ang II (10-7 mol·L-1) for 48 h increased cardiomyocyte apoptosis, PNS (25, 100 mg·mL-1) increased myocyte viability. PNS(50 mg·mL-1) significantly decreased this Ang II-induced rat cardiomyocyte apoptosis(P < 0.05) and decreased fluorescent intensity of intracellular calcium. Conclusion: PNS has a significant effect on Ang II-induced rat cardiomyocytes apoptosis in vitro by alleviating intracellular calcium overload.
Persistent Identifierhttp://hdl.handle.net/10722/92104
ISSN
2015 SCImago Journal Rankings: 0.164

 

DC FieldValueLanguage
dc.contributor.authorChen, Y-Jen_HK
dc.contributor.authorLi, J-Den_HK
dc.contributor.authorHuang, Q-Fen_HK
dc.date.accessioned2010-09-17T10:36:12Z-
dc.date.available2010-09-17T10:36:12Z-
dc.date.issued2005en_HK
dc.identifier.citationZhongguo Zhongyao Zazhi, 2005, v. 30 n. 10, p. 778-781en_HK
dc.identifier.issn1001-5302en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92104-
dc.description.abstractObjective: To study the protective effects of Panax notoginseng saponins(PNS) on angiotensin II (Ang II)-induced rat cardiomyocyte apoptosis in vitro and the probable mechanism. Method: Cultured cardiomyocytes from neonatal rats were stimulated with Ang II. Cell viability was measured by MTT. Apoptosis was evaluated using Acridine Orange(AO) fluorescent dye staining and flow cytometry; Fluo-3 AM was used to test the change of intracellular free calcium. Result: It was found that incubating with Ang II (10-7 mol·L-1) for 48 h increased cardiomyocyte apoptosis, PNS (25, 100 mg·mL-1) increased myocyte viability. PNS(50 mg·mL-1) significantly decreased this Ang II-induced rat cardiomyocyte apoptosis(P < 0.05) and decreased fluorescent intensity of intracellular calcium. Conclusion: PNS has a significant effect on Ang II-induced rat cardiomyocytes apoptosis in vitro by alleviating intracellular calcium overload.en_HK
dc.languageengen_HK
dc.publisherZhongguo Zhongyao Zazhishe. The Journal's web site is located at http://zgzyzz.periodicals.net.cn/en_HK
dc.relation.ispartofZhongguo Zhongyao Zazhien_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleEffects of Panax notoginseng saponins on rat cardiomyocytes apoptosis induced by angiotengin II in vitroen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid16075720-
dc.identifier.scopuseid_2-s2.0-33745090341en_HK
dc.identifier.volume30en_HK
dc.identifier.issue10en_HK
dc.identifier.spage778en_HK
dc.identifier.epage781en_HK

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