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Article: Strong immunohistochemical expression of vascular endothelial growth factor predicts overall survival in head and neck squamous cell carcinoma

TitleStrong immunohistochemical expression of vascular endothelial growth factor predicts overall survival in head and neck squamous cell carcinoma
Authors
KeywordsSquamous cell carcinoma
VEGF
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals Of Surgical Oncology, 2007, v. 14 n. 12, p. 3558-3565 How to Cite?
AbstractBackground: Head and neck squamous cell carcinoma (HNSCC) has high morbidity and mortality, and its relationship with tumor angiogenesis as measured by mircovessel density (MVD) or vascular endothelial growth factor (VEGF) expression has shown mixed results, with some, but not others, reporting correlation with outcome. Methods: A retrospective study of 186 patients with HNSCC was performed. Patients were evaluated for MVD and VEGF and to correlate the levels with clinical parameters, including age at diagnosis, sex, site of tumor, stage, survival (disease free and overall), pathological tumor grade, and the presence of lymph node metastases. Results: The 186 cancers included the following sites: oral tongue (n = 69), palate (n = 9), maxillary sinus (n = 8), floor of mouth (n = 13), oropharynx (n = 27), hypopharynx (n = 26) and larynx (n = 34). Over three-quarters of patients had advanced tumor (stage III/IV) and 58.6% had lymph node metastases. MVD and VEGF were assessed in 166 and 164 cases, respectively, but these were not correlated with site and grade. The 3-year overall and disease-free survival rates were 55.4% and 53.2%, respectively. Both univariate and multivariate survival analysis showed that advanced T stage, nodal metastasis, and strong VEGF intensity were independent adverse predictors for overall and disease-free survival. In stage IV disease, strong VEGF immunoreactivity was found to be the single adverse factor affecting the overall survival and a contributory factor for disease-free survival. Conclusions: VEGF immunoreactivity is a strong predictor of adverse outcome, particularly in locoregionally advanced disease. © 2007 Society of Surgical Oncology.
Persistent Identifierhttp://hdl.handle.net/10722/92099
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, GMen_HK
dc.contributor.authorChan, AWHen_HK
dc.contributor.authorYu, KHen_HK
dc.contributor.authorKing, ADen_HK
dc.contributor.authorWong, KTen_HK
dc.contributor.authorChen, GGen_HK
dc.contributor.authorTsang, RKYen_HK
dc.contributor.authorChan, ABWen_HK
dc.date.accessioned2010-09-17T10:36:03Z-
dc.date.available2010-09-17T10:36:03Z-
dc.date.issued2007en_HK
dc.identifier.citationAnnals Of Surgical Oncology, 2007, v. 14 n. 12, p. 3558-3565en_HK
dc.identifier.issn1068-9265en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92099-
dc.description.abstractBackground: Head and neck squamous cell carcinoma (HNSCC) has high morbidity and mortality, and its relationship with tumor angiogenesis as measured by mircovessel density (MVD) or vascular endothelial growth factor (VEGF) expression has shown mixed results, with some, but not others, reporting correlation with outcome. Methods: A retrospective study of 186 patients with HNSCC was performed. Patients were evaluated for MVD and VEGF and to correlate the levels with clinical parameters, including age at diagnosis, sex, site of tumor, stage, survival (disease free and overall), pathological tumor grade, and the presence of lymph node metastases. Results: The 186 cancers included the following sites: oral tongue (n = 69), palate (n = 9), maxillary sinus (n = 8), floor of mouth (n = 13), oropharynx (n = 27), hypopharynx (n = 26) and larynx (n = 34). Over three-quarters of patients had advanced tumor (stage III/IV) and 58.6% had lymph node metastases. MVD and VEGF were assessed in 166 and 164 cases, respectively, but these were not correlated with site and grade. The 3-year overall and disease-free survival rates were 55.4% and 53.2%, respectively. Both univariate and multivariate survival analysis showed that advanced T stage, nodal metastasis, and strong VEGF intensity were independent adverse predictors for overall and disease-free survival. In stage IV disease, strong VEGF immunoreactivity was found to be the single adverse factor affecting the overall survival and a contributory factor for disease-free survival. Conclusions: VEGF immunoreactivity is a strong predictor of adverse outcome, particularly in locoregionally advanced disease. © 2007 Society of Surgical Oncology.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.orgen_HK
dc.relation.ispartofAnnals of Surgical Oncologyen_HK
dc.subjectSquamous cell carcinomaen_HK
dc.subjectVEGFen_HK
dc.titleStrong immunohistochemical expression of vascular endothelial growth factor predicts overall survival in head and neck squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailTsang, RKY: rkytsang@hku.hken_HK
dc.identifier.authorityTsang, RKY=rp01386en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1245/s10434-007-9632-0en_HK
dc.identifier.pmid17929099-
dc.identifier.scopuseid_2-s2.0-36349011848en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36349011848&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue12en_HK
dc.identifier.spage3558en_HK
dc.identifier.epage3565en_HK
dc.identifier.eissn1534-4681-
dc.identifier.isiWOS:000250976500040-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTse, GM=7006550419en_HK
dc.identifier.scopusauthoridChan, AWH=37019607700en_HK
dc.identifier.scopusauthoridYu, KH=7403385647en_HK
dc.identifier.scopusauthoridKing, AD=7403373163en_HK
dc.identifier.scopusauthoridWong, KT=7404760076en_HK
dc.identifier.scopusauthoridChen, GG=35291566400en_HK
dc.identifier.scopusauthoridTsang, RKY=7102940058en_HK
dc.identifier.scopusauthoridChan, ABW=35172573500en_HK

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