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Article: Influence of hydroxypropyl-β-cyclodextrin on stability of potassium dehydroandrographolidi succinas

TitleInfluence of hydroxypropyl-β-cyclodextrin on stability of potassium dehydroandrographolidi succinas
Authors
KeywordsHydroxypropyl-Β- Cyclodextrin
Inclusion Complex
Potassium Dehydroandrographolidi Succinas
Stability
Issue Date2006
Citation
Chinese Pharmaceutical Journal, 2006, v. 41 n. 5, p. 367-370 How to Cite?
AbstractOBJECTIVE: To investigate the effect of hydroxypropyl-β- cyclodextrin(HP-β-CD) on the stability of potassium dehydroandrographolidi succinas(DAS-K) in aqueous solution. METHODS: The degradation kinetics of DAS-K in aqueous solution were investigated at different pH, different HP-β-CD concentration and various temperatures. The rate constant(kc) for the degradation of DAS-K in inclusion complex and equilibrium constant(K A) were calculated by the curve-fitting method. RESULTS: The hydrolytic degradation of DAS-K followed first-order kinetics in different HP-β-CD concentration. The apparent rate contant(kobs) for the hydrolysis of the drug was not a linear function of HP-β-CD concentration and asymptotically approached a minimum value with increasing HP-β-CD concentration. The stabilizing effect of HP-β-CD on DAS-K was more significant at low temperature. CONCLUSION: HP-β-CD represents a visible means of stabilization of DAS-K solution in the study.
Persistent Identifierhttp://hdl.handle.net/10722/92092
ISSN
2015 SCImago Journal Rankings: 0.143
References

 

DC FieldValueLanguage
dc.contributor.authorLuo, W-Wen_HK
dc.contributor.authorHe, Y-Jen_HK
dc.contributor.authorWang, Len_HK
dc.contributor.authorMo, Yen_HK
dc.contributor.authorLin, L-Yen_HK
dc.contributor.authorChen, Yen_HK
dc.date.accessioned2010-09-17T10:35:51Z-
dc.date.available2010-09-17T10:35:51Z-
dc.date.issued2006en_HK
dc.identifier.citationChinese Pharmaceutical Journal, 2006, v. 41 n. 5, p. 367-370en_HK
dc.identifier.issn1001-2494en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92092-
dc.description.abstractOBJECTIVE: To investigate the effect of hydroxypropyl-β- cyclodextrin(HP-β-CD) on the stability of potassium dehydroandrographolidi succinas(DAS-K) in aqueous solution. METHODS: The degradation kinetics of DAS-K in aqueous solution were investigated at different pH, different HP-β-CD concentration and various temperatures. The rate constant(kc) for the degradation of DAS-K in inclusion complex and equilibrium constant(K A) were calculated by the curve-fitting method. RESULTS: The hydrolytic degradation of DAS-K followed first-order kinetics in different HP-β-CD concentration. The apparent rate contant(kobs) for the hydrolysis of the drug was not a linear function of HP-β-CD concentration and asymptotically approached a minimum value with increasing HP-β-CD concentration. The stabilizing effect of HP-β-CD on DAS-K was more significant at low temperature. CONCLUSION: HP-β-CD represents a visible means of stabilization of DAS-K solution in the study.en_HK
dc.languageengen_HK
dc.relation.ispartofChinese Pharmaceutical Journalen_HK
dc.subjectHydroxypropyl-Β- Cyclodextrinen_HK
dc.subjectInclusion Complexen_HK
dc.subjectPotassium Dehydroandrographolidi Succinasen_HK
dc.subjectStabilityen_HK
dc.titleInfluence of hydroxypropyl-β-cyclodextrin on stability of potassium dehydroandrographolidi succinasen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-33748801764en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748801764&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue5en_HK
dc.identifier.spage367en_HK
dc.identifier.epage370en_HK

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