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Article: Angiogenesis of renal cell carcinoma: perfusion CT findings

TitleAngiogenesis of renal cell carcinoma: perfusion CT findings
Authors
KeywordsMicrovascular Density
Perfusion Imaging
Renal Cell Carcinoma
Tomography
Tumor Angiogenesis
Vascular Endothelial Growth Factor
X-Ray Computed
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00261/
Citation
Abdominal Imaging, 2009, p. 1-7 How to Cite?
AbstractObjective: To observe the perfusion CT findings of renal cell carcinoma (RCC) and prospectively correlate perfusion CT parameters with tumor MVD and VEGF expression. Methods: Dynamic contrast-enhanced multislice spiral CT was performed prospectively in 73 cases with histologically proven RCC (65 clear cell, 3 papillary, and 5 chromophobe). Blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface-area product (PS) of RCC and normal renal cortex were measured, respectively. The tumor MVD count and VEGF expression level were determined by immunohistochemistry with specific monoclonal antibodies. Results: There was significant difference between BF, BV, MTT, and PS of normal renal cortex (454.32 ± 110.90 mL/min/100 g, 23.53 ± 5.71 mL/100 g, 3.62 ± 1.38 s, 63.95 ± 18.85 mL/min/100 g) and RCC (261.96 ± 175.86 mL/min/100 g, 17.17 ± 8.34 mL/100 g, 7.08 ± 3.42 s, 25.07 ± 13.20 mL/min/100 g) (P < 0.01). BF and BV among RCC histologic subtypes were significantly different (P < 0.05), MTT and PS were not (P > 0.05). MVD (42.29 ± 21.00) of RCC is positively correlated with BF, BV, and PS (P < 0.01), not with MTT (P > 0.05). No relationship was found between the expression levels of VEGF and any perfusion CT parameter. Conclusions: Perfusion CT is a feasible technique to assess tissue perfusion in patients with RCC. BV, BF, and PS correlate positively with MVD and may reflect angiogenesis of RCC. © 2009 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/92089
ISSN
2015 Impact Factor: 2.189
2015 SCImago Journal Rankings: 0.723
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Yen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorDai, Jen_HK
dc.contributor.authorFeng, Xen_HK
dc.contributor.authorLu, Hen_HK
dc.contributor.authorZhou, Cen_HK
dc.date.accessioned2010-09-17T10:35:45Z-
dc.date.available2010-09-17T10:35:45Z-
dc.date.issued2009en_HK
dc.identifier.citationAbdominal Imaging, 2009, p. 1-7en_HK
dc.identifier.issn0942-8925en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92089-
dc.description.abstractObjective: To observe the perfusion CT findings of renal cell carcinoma (RCC) and prospectively correlate perfusion CT parameters with tumor MVD and VEGF expression. Methods: Dynamic contrast-enhanced multislice spiral CT was performed prospectively in 73 cases with histologically proven RCC (65 clear cell, 3 papillary, and 5 chromophobe). Blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface-area product (PS) of RCC and normal renal cortex were measured, respectively. The tumor MVD count and VEGF expression level were determined by immunohistochemistry with specific monoclonal antibodies. Results: There was significant difference between BF, BV, MTT, and PS of normal renal cortex (454.32 ± 110.90 mL/min/100 g, 23.53 ± 5.71 mL/100 g, 3.62 ± 1.38 s, 63.95 ± 18.85 mL/min/100 g) and RCC (261.96 ± 175.86 mL/min/100 g, 17.17 ± 8.34 mL/100 g, 7.08 ± 3.42 s, 25.07 ± 13.20 mL/min/100 g) (P < 0.01). BF and BV among RCC histologic subtypes were significantly different (P < 0.05), MTT and PS were not (P > 0.05). MVD (42.29 ± 21.00) of RCC is positively correlated with BF, BV, and PS (P < 0.01), not with MTT (P > 0.05). No relationship was found between the expression levels of VEGF and any perfusion CT parameter. Conclusions: Perfusion CT is a feasible technique to assess tissue perfusion in patients with RCC. BV, BF, and PS correlate positively with MVD and may reflect angiogenesis of RCC. © 2009 Springer Science+Business Media, LLC.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00261/en_HK
dc.relation.ispartofAbdominal Imagingen_HK
dc.subjectMicrovascular Densityen_HK
dc.subjectPerfusion Imagingen_HK
dc.subjectRenal Cell Carcinomaen_HK
dc.subjectTomographyen_HK
dc.subjectTumor Angiogenesisen_HK
dc.subjectVascular Endothelial Growth Factoren_HK
dc.subjectX-Ray Computeden_HK
dc.titleAngiogenesis of renal cell carcinoma: perfusion CT findingsen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00261-009-9565-0en_HK
dc.identifier.pmid19763683-
dc.identifier.scopuseid_2-s2.0-78651248406-
dc.identifier.spage1en_HK
dc.identifier.epage7en_HK
dc.identifier.eissn1432-0509-
dc.identifier.isiWOS:000282424100018-
dc.identifier.citeulike5809636-

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