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Article: Magnetic resonance imaging for the detection of nasopharyngeal carcinoma

TitleMagnetic resonance imaging for the detection of nasopharyngeal carcinoma
Authors
KeywordsTradenames
Issue Date2006
PublisherAmerican Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.org
Citation
American Journal Of Neuroradiology, 2006, v. 27 n. 6, p. 1288-1291 How to Cite?
AbstractBACKGROUND: Endoscopic guided biopsy (EGB) is performed after an initial endoscopy for the investigation of patients with suspected nasopharyngeal carcinoma (NPC). The aim of the study was to determine whether MR imaging has the potential to replace invasive EGB in patients with a normal endoscopy. PATIENTS AND METHODS: Data from 2 groups of patients was reviewed, group 1 with proved NPC for MR staging (n = 456) and group 2 with suspected NPC (n = 77). The sensitivity was calculated for group 1 and sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for group 2. RESULTS: In group 1, which included 118 of 456 (26%) with stage 1 disease, cancer was detected in all patients, giving a sensitivity of 100%. In group 2, MR imaging was negative for NPC in 70 (91 %) patients, and no cancer has been detected on follow-up (follow-up range, 1-90 months; mean, 36 months). MR imaging was positive for NPC in 7 (9%) patients and NPC was confirmed by biopsy in 3 (4%). Two of these 3 patients had undergone negative endoscopy and biopsy before the MR imaging. NPC was not present in the remaining 4 patients, 2 of whom were found to have lymphoid hyperplasia. MR imaging had a sensitivity of 100%, specificity of 95%, NPV of 100%, PPV of 43%, and accuracy of 95%. CONCLUSION: MR imaging has the potential to screen healthy patients who do not require EGB and direct the site of biopsy in small cancers that may be missed by endoscopy. On the basis of these results, a prospective study is planned.
Persistent Identifierhttp://hdl.handle.net/10722/92084
ISSN
2015 Impact Factor: 3.124
2015 SCImago Journal Rankings: 1.602
References

 

DC FieldValueLanguage
dc.contributor.authorKing, ADen_HK
dc.contributor.authorVlantis, ACen_HK
dc.contributor.authorTsang, RKYen_HK
dc.contributor.authorGary, TMKen_HK
dc.contributor.authorAu, AKYen_HK
dc.contributor.authorChan, CYen_HK
dc.contributor.authorKok, SYen_HK
dc.contributor.authorKwok, WTen_HK
dc.contributor.authorLui, HKen_HK
dc.contributor.authorAhuja, ATen_HK
dc.date.accessioned2010-09-17T10:35:36Z-
dc.date.available2010-09-17T10:35:36Z-
dc.date.issued2006en_HK
dc.identifier.citationAmerican Journal Of Neuroradiology, 2006, v. 27 n. 6, p. 1288-1291en_HK
dc.identifier.issn0195-6108en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92084-
dc.description.abstractBACKGROUND: Endoscopic guided biopsy (EGB) is performed after an initial endoscopy for the investigation of patients with suspected nasopharyngeal carcinoma (NPC). The aim of the study was to determine whether MR imaging has the potential to replace invasive EGB in patients with a normal endoscopy. PATIENTS AND METHODS: Data from 2 groups of patients was reviewed, group 1 with proved NPC for MR staging (n = 456) and group 2 with suspected NPC (n = 77). The sensitivity was calculated for group 1 and sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy for group 2. RESULTS: In group 1, which included 118 of 456 (26%) with stage 1 disease, cancer was detected in all patients, giving a sensitivity of 100%. In group 2, MR imaging was negative for NPC in 70 (91 %) patients, and no cancer has been detected on follow-up (follow-up range, 1-90 months; mean, 36 months). MR imaging was positive for NPC in 7 (9%) patients and NPC was confirmed by biopsy in 3 (4%). Two of these 3 patients had undergone negative endoscopy and biopsy before the MR imaging. NPC was not present in the remaining 4 patients, 2 of whom were found to have lymphoid hyperplasia. MR imaging had a sensitivity of 100%, specificity of 95%, NPV of 100%, PPV of 43%, and accuracy of 95%. CONCLUSION: MR imaging has the potential to screen healthy patients who do not require EGB and direct the site of biopsy in small cancers that may be missed by endoscopy. On the basis of these results, a prospective study is planned.en_HK
dc.languageengen_HK
dc.publisherAmerican Society of Neuroradiology. The Journal's web site is located at http://www.ajnr.orgen_HK
dc.relation.ispartofAmerican Journal of Neuroradiologyen_HK
dc.subjectTradenamesen_HK
dc.titleMagnetic resonance imaging for the detection of nasopharyngeal carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailTsang, RKY: rkytsang@hku.hken_HK
dc.identifier.authorityTsang, RKY=rp01386en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-33747425616en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747425616&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume27en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1288en_HK
dc.identifier.epage1291en_HK
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKing, AD=7403373163en_HK
dc.identifier.scopusauthoridVlantis, AC=35585515400en_HK
dc.identifier.scopusauthoridTsang, RKY=7102940058en_HK
dc.identifier.scopusauthoridGary, TMK=14070049500en_HK
dc.identifier.scopusauthoridAu, AKY=36900623300en_HK
dc.identifier.scopusauthoridChan, CY=7404814582en_HK
dc.identifier.scopusauthoridKok, SY=14070247400en_HK
dc.identifier.scopusauthoridKwok, WT=8578541800en_HK
dc.identifier.scopusauthoridLui, HK=14070349000en_HK
dc.identifier.scopusauthoridAhuja, AT=35449659800en_HK

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