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Article: HER2 expression predicts improved survival in patients with cervical node-positive head and neck squamous cell carcinoma

TitleHER2 expression predicts improved survival in patients with cervical node-positive head and neck squamous cell carcinoma
Authors
KeywordsAdult
Age Distribution
Aged
Article
Cancer Grading
Cancer Patient
Cancer Staging
Cancer Survival
Cervical Lymph Node
Controlled Study
Disease Free Survival
Female
Gene Expression
Head And Neck Carcinoma
Human
Human Tissue
Hypopharynx Carcinoma
Immunohistochemistry
Jaw Cancer
Larynx Carcinoma
Lymph Node
Lymph Node Metastasis
Major Clinical Study
Male
Maxilla Sinus Carcinoma
Mouth Carcinoma
Oropharynx Carcinoma
Overall Survival
Prediction
Prognosis
Sex Difference
Squamous Cell Carcinoma
Tongue Carcinoma
Issue Date2009
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ohns
Citation
Otolaryngology - Head And Neck Surgery, 2009, v. 141 n. 4, p. 467-473 How to Cite?
AbstractObjective: To investigate the prognostic value of HER2 and p63 expression in head and neck squamous cell carcinoma (HNSCC). Study Design: A case review of 186 HNSCCs from the oral tongue, palate, maxillary sinus, floor of mouth, oropharynx, hypopharynx, and larynx. Subjects and Methods: All primary tumor specimens were evaluated by immunohistochemistry for HER2 and p63 expressions, which were correlated with clinical parameters including age, sex, grade, lymph node metastases, stage, and survival. Results: One hundred forty-one patients had stage III-IV disease and 109 had lymph node metastases. For all cases, T and N stages were significant prognostic predictors for both overall and disease-free survivals. In the node-positive subgroup, T stage and HER2 expression were significant prognostic predictors for both overall and disease-free survivals. Conclusion: HER2 may be associated with longer survival in node-positive patients with HNSCC. © 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/92078
ISSN
2015 Impact Factor: 2.021
2015 SCImago Journal Rankings: 1.176
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, GMen_HK
dc.contributor.authorYu, KHen_HK
dc.contributor.authorChan, AWHen_HK
dc.contributor.authorKing, ADen_HK
dc.contributor.authorChen, GGen_HK
dc.contributor.authorWong, KTen_HK
dc.contributor.authorTsang, RKYen_HK
dc.contributor.authorChan, ABWen_HK
dc.date.accessioned2010-09-17T10:35:26Z-
dc.date.available2010-09-17T10:35:26Z-
dc.date.issued2009en_HK
dc.identifier.citationOtolaryngology - Head And Neck Surgery, 2009, v. 141 n. 4, p. 467-473en_HK
dc.identifier.issn0194-5998en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92078-
dc.description.abstractObjective: To investigate the prognostic value of HER2 and p63 expression in head and neck squamous cell carcinoma (HNSCC). Study Design: A case review of 186 HNSCCs from the oral tongue, palate, maxillary sinus, floor of mouth, oropharynx, hypopharynx, and larynx. Subjects and Methods: All primary tumor specimens were evaluated by immunohistochemistry for HER2 and p63 expressions, which were correlated with clinical parameters including age, sex, grade, lymph node metastases, stage, and survival. Results: One hundred forty-one patients had stage III-IV disease and 109 had lymph node metastases. For all cases, T and N stages were significant prognostic predictors for both overall and disease-free survivals. In the node-positive subgroup, T stage and HER2 expression were significant prognostic predictors for both overall and disease-free survivals. Conclusion: HER2 may be associated with longer survival in node-positive patients with HNSCC. © 2009 American Academy of Otolaryngology-Head and Neck Surgery Foundation.en_HK
dc.languageengen_HK
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ohnsen_HK
dc.relation.ispartofOtolaryngology - Head and Neck Surgeryen_HK
dc.subjectAdulten_HK
dc.subjectAge Distributionen_HK
dc.subjectAgeden_HK
dc.subjectArticleen_HK
dc.subjectCancer Gradingen_HK
dc.subjectCancer Patienten_HK
dc.subjectCancer Stagingen_HK
dc.subjectCancer Survivalen_HK
dc.subjectCervical Lymph Nodeen_HK
dc.subjectControlled Studyen_HK
dc.subjectDisease Free Survivalen_HK
dc.subjectFemaleen_HK
dc.subjectGene Expressionen_HK
dc.subjectHead And Neck Carcinomaen_HK
dc.subjectHumanen_HK
dc.subjectHuman Tissueen_HK
dc.subjectHypopharynx Carcinomaen_HK
dc.subjectImmunohistochemistryen_HK
dc.subjectJaw Canceren_HK
dc.subjectLarynx Carcinomaen_HK
dc.subjectLymph Nodeen_HK
dc.subjectLymph Node Metastasisen_HK
dc.subjectMajor Clinical Studyen_HK
dc.subjectMaleen_HK
dc.subjectMaxilla Sinus Carcinomaen_HK
dc.subjectMouth Carcinomaen_HK
dc.subjectOropharynx Carcinomaen_HK
dc.subjectOverall Survivalen_HK
dc.subjectPredictionen_HK
dc.subjectPrognosisen_HK
dc.subjectSex Differenceen_HK
dc.subjectSquamous Cell Carcinomaen_HK
dc.subjectTongue Carcinomaen_HK
dc.titleHER2 expression predicts improved survival in patients with cervical node-positive head and neck squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailTsang, RKY: rkytsang@hku.hken_HK
dc.identifier.authorityTsang, RKY=rp01386en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.otohns.2009.06.747en_HK
dc.identifier.pmid19786214-
dc.identifier.scopuseid_2-s2.0-70349321265en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349321265&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume141en_HK
dc.identifier.issue4en_HK
dc.identifier.spage467en_HK
dc.identifier.epage473en_HK
dc.identifier.isiWOS:000270443800006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTse, GM=7006550419en_HK
dc.identifier.scopusauthoridYu, KH=7403385647en_HK
dc.identifier.scopusauthoridChan, AWH=37019607700en_HK
dc.identifier.scopusauthoridKing, AD=7403373163en_HK
dc.identifier.scopusauthoridChen, GG=35291566400en_HK
dc.identifier.scopusauthoridWong, KT=34978071600en_HK
dc.identifier.scopusauthoridTsang, RKY=7102940058en_HK
dc.identifier.scopusauthoridChan, ABW=35172573500en_HK
dc.identifier.citeulike5886002-

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