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Article: The effect of simvastatin on the serum monocyte chemoattractant protein-1 and intracellular adhesion molecule-1 levels in diabetic rats

TitleThe effect of simvastatin on the serum monocyte chemoattractant protein-1 and intracellular adhesion molecule-1 levels in diabetic rats
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jdiacomp
Citation
Journal of Diabetes and its Complications, 2009, v. 23 n. 3, p. 214-218 How to Cite?
AbstractObjective: This study aimed to observe the effect of simvastatin on the serum monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 (ICAM-1) levels and to probe its protective mechanisms on macroangiopathy in diabetic rats. Methods: Twenty-four Wistar rats were randomly assigned to a normal control group (Group A, n=8), and STZ-induced diabetic group (Group B, n=8), or a simvastatin-treated diabetic group (Group C, n=8). Rats in Group C were treated with simvastatin (20 mg kg-1 day-1) 1 week after the establishment of the diabetic model. Groups A and B were treated with corresponding sodium chloride. Peripheral blood glucose was tested weekly; serum MCP-1, ICAM-1, and HbA1c levels were tested at the eighth week. Results: At the second, fourth, and eighth week, peripheral blood glucose levels in Group B were similar to those of Group C, which were much higher than those of Group A. Serum MCP-1 and ICAM-1 levels in Groups B and C were higher than those of Group A (P<.01), and serum MCP-1 and ICAM-1 levels in Group C were lower than those of Group B (P<.01); HbA1c was not significantly different between Group C and Group B. Conclusion: Simvastatin has the effect of anti-inflammation, which may play some protection against the progress of atherosclerosis in diabetic rats. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/92077
ISSN
2015 Impact Factor: 2.955
2015 SCImago Journal Rankings: 1.632
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLin, Yen_HK
dc.contributor.authorYe, Sen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorLi, Xen_HK
dc.contributor.authorYang, G-wen_HK
dc.contributor.authorFan, Aen_HK
dc.contributor.authorWang, Yen_HK
dc.date.accessioned2010-09-17T10:35:24Z-
dc.date.available2010-09-17T10:35:24Z-
dc.date.issued2009en_HK
dc.identifier.citationJournal of Diabetes and its Complications, 2009, v. 23 n. 3, p. 214-218en_HK
dc.identifier.issn1056-8727en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92077-
dc.description.abstractObjective: This study aimed to observe the effect of simvastatin on the serum monocyte chemoattractant protein-1 (MCP-1) and intracellular adhesion molecule-1 (ICAM-1) levels and to probe its protective mechanisms on macroangiopathy in diabetic rats. Methods: Twenty-four Wistar rats were randomly assigned to a normal control group (Group A, n=8), and STZ-induced diabetic group (Group B, n=8), or a simvastatin-treated diabetic group (Group C, n=8). Rats in Group C were treated with simvastatin (20 mg kg-1 day-1) 1 week after the establishment of the diabetic model. Groups A and B were treated with corresponding sodium chloride. Peripheral blood glucose was tested weekly; serum MCP-1, ICAM-1, and HbA1c levels were tested at the eighth week. Results: At the second, fourth, and eighth week, peripheral blood glucose levels in Group B were similar to those of Group C, which were much higher than those of Group A. Serum MCP-1 and ICAM-1 levels in Groups B and C were higher than those of Group A (P<.01), and serum MCP-1 and ICAM-1 levels in Group C were lower than those of Group B (P<.01); HbA1c was not significantly different between Group C and Group B. Conclusion: Simvastatin has the effect of anti-inflammation, which may play some protection against the progress of atherosclerosis in diabetic rats. © 2009 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jdiacompen_HK
dc.relation.ispartofJournal of Diabetes and its Complicationsen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleThe effect of simvastatin on the serum monocyte chemoattractant protein-1 and intracellular adhesion molecule-1 levels in diabetic ratsen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jdiacomp.2007.09.003en_HK
dc.identifier.pmid18413153-
dc.identifier.scopuseid_2-s2.0-65249124085en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65249124085&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue3en_HK
dc.identifier.spage214en_HK
dc.identifier.epage218en_HK
dc.identifier.isiWOS:000265765200010-
dc.identifier.citeulike5485746-

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