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Article: Swallowing function after altered fractionation radiotherapy for head and neck carcinoma

TitleSwallowing function after altered fractionation radiotherapy for head and neck carcinoma
Authors
KeywordsAccelerated radiotherapy
Head and neck carcinoma
Hyperfractionated radiotherapy
Swallowing function
Issue Date2005
PublisherScientific Communications International Ltd. The Journal's web site is located at http://www.hkcr.org/
Citation
Journal Of The Hong Kong College Of Radiologists, 2005, v. 8 n. 4, p. 207-213 How to Cite?
AbstractObjective: To investigate swallowing function outcome in patients with head and neck cancer who received altered fractionation radiotherapy. Patients and Methods: Forty nine patients with bulky T2 tumours or American Joint Committee on Cancer stage III/IV disease were treated with accelerated radiotherapy with concomitant boost to 72 Gy-80 Gy or hyperfractionated accelerated radiotherapy to 76.8 Gy. The pre- and post-radiotherapy swallowing dysfunction were scored with a physician-rated scale of grade 0 (normal) to 4 (severe impairment). The Wilcoxon signed rank test was used to compare pre- and post-radiotherapy scores in patients who did not have local failure or a second head and neck primary. Results: At a median follow-up of 15.7 months (range, 3.7 to 66.0 months), 9 patients had developed permanent grade 3/4 swallowing dysfunction. This was associated with local failure in 8 patients. The 1-year actuarial permanent grade 3/4 swallowing dysfunction-free survival was 93% for the whole patient series. Of 26 patients (53%) who did not develop local failure or a second head and neck primary, the worst late swallowing dysfunction scores (mean, 0.81; median, 1) were significantly higher than the pre-radiotherapy scores (mean, 0.23; median, 0; p = 0.0016). Conclusions: Permanent severe swallowing dysfunction was uncommon during early follow-up in local failure-free patients who received curative altered fractionation radiotherapy for locoregionally advanced head and neck carcinoma. © 2005 Hong Kong College of Radiologists.
Persistent Identifierhttp://hdl.handle.net/10722/92076
ISSN
References

 

DC FieldValueLanguage
dc.contributor.authorYu, KHen_HK
dc.contributor.authorChua, Men_HK
dc.contributor.authorVlantis, ACen_HK
dc.contributor.authorKam, MKMen_HK
dc.contributor.authorLee, WYen_HK
dc.contributor.authorTsang, RKYen_HK
dc.contributor.authorYuen, HYen_HK
dc.contributor.authorHui, EPen_HK
dc.contributor.authorChan, ATCen_HK
dc.date.accessioned2010-09-17T10:35:22Z-
dc.date.available2010-09-17T10:35:22Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of The Hong Kong College Of Radiologists, 2005, v. 8 n. 4, p. 207-213en_HK
dc.identifier.issn1029-5097en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92076-
dc.description.abstractObjective: To investigate swallowing function outcome in patients with head and neck cancer who received altered fractionation radiotherapy. Patients and Methods: Forty nine patients with bulky T2 tumours or American Joint Committee on Cancer stage III/IV disease were treated with accelerated radiotherapy with concomitant boost to 72 Gy-80 Gy or hyperfractionated accelerated radiotherapy to 76.8 Gy. The pre- and post-radiotherapy swallowing dysfunction were scored with a physician-rated scale of grade 0 (normal) to 4 (severe impairment). The Wilcoxon signed rank test was used to compare pre- and post-radiotherapy scores in patients who did not have local failure or a second head and neck primary. Results: At a median follow-up of 15.7 months (range, 3.7 to 66.0 months), 9 patients had developed permanent grade 3/4 swallowing dysfunction. This was associated with local failure in 8 patients. The 1-year actuarial permanent grade 3/4 swallowing dysfunction-free survival was 93% for the whole patient series. Of 26 patients (53%) who did not develop local failure or a second head and neck primary, the worst late swallowing dysfunction scores (mean, 0.81; median, 1) were significantly higher than the pre-radiotherapy scores (mean, 0.23; median, 0; p = 0.0016). Conclusions: Permanent severe swallowing dysfunction was uncommon during early follow-up in local failure-free patients who received curative altered fractionation radiotherapy for locoregionally advanced head and neck carcinoma. © 2005 Hong Kong College of Radiologists.en_HK
dc.languageengen_HK
dc.publisherScientific Communications International Ltd. The Journal's web site is located at http://www.hkcr.org/en_HK
dc.relation.ispartofJournal of the Hong Kong College of Radiologistsen_HK
dc.subjectAccelerated radiotherapyen_HK
dc.subjectHead and neck carcinomaen_HK
dc.subjectHyperfractionated radiotherapyen_HK
dc.subjectSwallowing functionen_HK
dc.titleSwallowing function after altered fractionation radiotherapy for head and neck carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailTsang, RKY: rkytsang@hku.hken_HK
dc.identifier.authorityTsang, RKY=rp01386en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-42649133137en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42649133137&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue4en_HK
dc.identifier.spage207en_HK
dc.identifier.epage213en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridYu, KH=7403385647en_HK
dc.identifier.scopusauthoridChua, M=24166391800en_HK
dc.identifier.scopusauthoridVlantis, AC=35585515400en_HK
dc.identifier.scopusauthoridKam, MKM=35332321400en_HK
dc.identifier.scopusauthoridLee, WY=7407086307en_HK
dc.identifier.scopusauthoridTsang, RKY=7102940058en_HK
dc.identifier.scopusauthoridYuen, HY=7103253652en_HK
dc.identifier.scopusauthoridHui, EP=7005081895en_HK
dc.identifier.scopusauthoridChan, ATC=13404833700en_HK

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