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Article: Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer

TitlePromoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer
Authors
KeywordsGastric cancer
Methylation
SLC19A3
Issue Date2009
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/TBI
Citation
Tumor Biology, 2009, v. 30 n. 5-6, p. 242-248 How to Cite?
Abstract
As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development. © 2009 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/92056
ISSN
2013 Impact Factor: 2.840
ISI Accession Number ID
Funding AgencyGrant Number
Institute of Digestive Disease
Chinese University of Hong Kong2007.1.034
Funding Information:

The project was supported by Research Funding from the Institute of Digestive Disease, the Chinese University of Hong Kong and CUHK direct grant (2007.1.034).

References

 

Author Affiliations
  1. The University of Hong Kong
  2. City University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorLiu, Xen_HK
dc.contributor.authorLam, EKYen_HK
dc.contributor.authorWang, Xen_HK
dc.contributor.authorZhang, Jen_HK
dc.contributor.authorCheng, YYen_HK
dc.contributor.authorLam, YWen_HK
dc.contributor.authorNg, EKOen_HK
dc.contributor.authorYu, Jen_HK
dc.contributor.authorChan, FKLen_HK
dc.contributor.authorJin, Hen_HK
dc.contributor.authorSung, JJYen_HK
dc.date.accessioned2010-09-17T10:34:47Z-
dc.date.available2010-09-17T10:34:47Z-
dc.date.issued2009en_HK
dc.identifier.citationTumor Biology, 2009, v. 30 n. 5-6, p. 242-248en_HK
dc.identifier.issn1010-4283en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92056-
dc.description.abstractAs an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development. © 2009 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/TBIen_HK
dc.relation.ispartofTumor Biologyen_HK
dc.subjectGastric canceren_HK
dc.subjectMethylationen_HK
dc.subjectSLC19A3en_HK
dc.subject.meshCell Survival - genetics-
dc.subject.meshDNA Methylation-
dc.subject.meshMembrane Transport Proteins - genetics-
dc.subject.meshPromoter Regions, Genetic - genetics-
dc.subject.meshStomach Neoplasms - genetics - pathology-
dc.titlePromoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1010-4283&volume=30&issue=5-6&spage=242&epage=248&date=2009&atitle=Promoter+hypermethylation+mediates+downregulation+of+thiamine+receptor+SLC19A3+in+gastric+cancer-
dc.identifier.emailNg, EKO: ngko@hku.hken_HK
dc.identifier.authorityNg, EKO=rp01364en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000243767en_HK
dc.identifier.pmid19816091en_HK
dc.identifier.scopuseid_2-s2.0-73749088408en_HK
dc.identifier.hkuros168714-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-73749088408&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue5-6en_HK
dc.identifier.spage242en_HK
dc.identifier.epage248en_HK
dc.identifier.isiWOS:000272106800002-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLiu, X=7409289484en_HK
dc.identifier.scopusauthoridLam, EKY=8644138600en_HK
dc.identifier.scopusauthoridWang, X=7501854916en_HK
dc.identifier.scopusauthoridZhang, J=7601359171en_HK
dc.identifier.scopusauthoridCheng, YY=7404914973en_HK
dc.identifier.scopusauthoridLam, YW=35290612300en_HK
dc.identifier.scopusauthoridNg, EKO=21135553700en_HK
dc.identifier.scopusauthoridYu, J=35351306800en_HK
dc.identifier.scopusauthoridChan, FKL=7202586434en_HK
dc.identifier.scopusauthoridJin, H=24577511700en_HK
dc.identifier.scopusauthoridSung, JJY=35405352400en_HK

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