Article: Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer
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- Publisher Website: 10.1159/000243767
- Scopus: eid_2-s2.0-73749088408
- PMID: 19816091
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| Title | Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer |
|---|---|
| Authors | Liu, X1 Lam, EKY1 Wang, X2 Zhang, J1 Cheng, YY1 Lam, YW2 Ng, EKO1 Yu, J1 Chan, FKL1 Jin, H1 Sung, JJY1 |
| Keywords | Gastric cancer Methylation SLC19A3 |
| Issue Date | 2009 |
| Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/TBI |
| Citation | Tumor Biology, 2009, v. 30 n. 5-6, p. 242-248 [How to Cite?] DOI: http://dx.doi.org/10.1159/000243767 |
| Abstract | As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development. © 2009 S. Karger AG, Basel. |
| ISSN | 1010-4283 2011 Impact Factor: 2.143 2011 SCImago Journal Rankings: 0.210 |
| DOI | http://dx.doi.org/10.1159/000243767 |
| References | References in Scopus |
| dc.contributor.author | Liu, X | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Lam, EKY | ||||||
| dc.contributor.author | Wang, X | ||||||
| dc.contributor.author | Zhang, J | ||||||
| dc.contributor.author | Cheng, YY | ||||||
| dc.contributor.author | Lam, YW | ||||||
| dc.contributor.author | Ng, EKO | ||||||
| dc.contributor.author | Yu, J | ||||||
| dc.contributor.author | Chan, FKL | ||||||
| dc.contributor.author | Jin, H | ||||||
| dc.contributor.author | Sung, JJY | ||||||
| dc.date.accessioned | 2010-09-17T10:34:47Z | ||||||
| dc.date.available | 2010-09-17T10:34:47Z | ||||||
| dc.date.issued | 2009 | ||||||
| dc.description.abstract | As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development. © 2009 S. Karger AG, Basel. | ||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||
| dc.identifier.citation | Tumor Biology, 2009, v. 30 n. 5-6, p. 242-248 [How to Cite?] DOI: http://dx.doi.org/10.1159/000243767 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1159/000243767 | ||||||
| dc.identifier.epage | 248 | ||||||
| dc.identifier.hkuros | 168714 | ||||||
| dc.identifier.isi | WOS:000272106800002
Funding Information: The project was supported by Research Funding from the Institute of Digestive Disease, the Chinese University of Hong Kong and CUHK direct grant (2007.1.034). | ||||||
| dc.identifier.issn | 1010-4283 2011 Impact Factor: 2.143 2011 SCImago Journal Rankings: 0.210 | ||||||
| dc.identifier.issue | 5-6 | ||||||
| dc.identifier.openurl | | ||||||
| dc.identifier.pmid | 19816091 | ||||||
| dc.identifier.scopus | eid_2-s2.0-73749088408 | ||||||
| dc.identifier.spage | 242 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/92056 | ||||||
| dc.identifier.volume | 30 | ||||||
| dc.language | eng | ||||||
| dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/TBI | ||||||
| dc.publisher.place | Switzerland | ||||||
| dc.relation.ispartof | Tumor Biology | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.subject.mesh | Cell Survival - genetics | ||||||
| dc.subject.mesh | DNA Methylation | ||||||
| dc.subject.mesh | Membrane Transport Proteins - genetics | ||||||
| dc.subject.mesh | Promoter Regions, Genetic - genetics | ||||||
| dc.subject.mesh | Stomach Neoplasms - genetics - pathology | ||||||
| dc.subject | Gastric cancer | ||||||
| dc.subject | Methylation | ||||||
| dc.subject | SLC19A3 | ||||||
| dc.title | Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer | ||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong
- City University of Hong Kong