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Article: Hemorrhagic stroke associated with antidepressant use in patients with depression: Does degree of serotonin reuptake inhibition matter?

TitleHemorrhagic stroke associated with antidepressant use in patients with depression: Does degree of serotonin reuptake inhibition matter?
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/5669
Citation
Pharmacoepidemiology and Drug Safety, 2009, v. 18 n. 3, p. 196-202 How to Cite?
AbstractObjective: This study aimed to determine whether the degree of serotonin (5-HT) reuptake inhibition affects risk of hemorrhagic stroke associated with antidepressant use in patients with depression. Method: A population-based, nested case-control study was performed using a managed care medical claims database. Ninety two depressed patients with a diagnosis of hemorrhagic stroke were identified and matched with 552 controls by age, sex, and year of index date of depression (IDD). Diagnoses of depression, hemorrhagic stroke, and other medical comorbidities were identified using ICD-9 codes. Antidepressants were classified as high, medium, or low reuptake inhibition based on their affinities for the 5-HT reuptake transporter, determined using their respective equilibrium dissociation constants (KD; high: KD < 1 nM; medium: 1 ≤ KD < 10 nM; low: KD ≥ 10 nM). Conditional logistic regression analysis was performed to estimate the crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of the risk of hemorrhagic stroke. Results: Compared to non-users of antidepressants, risk of hemorrhagic stroke did not significantly differ between patients who had ever used antidepressants with high (OR=.82; 95% CI=.44-1.55), medium (OR=0.93; 95% CI=0.37\2.31), or low (OR=0.38; 95% CI=0.11-1.41) 5-HTT inhibition. Conclusion: Risk of hemorrhagic stroke associated with antidepressant use may not be related to an antidepressant's degree of 5-HT reuptake inhibition. Given the limitations of this study, additional studies are needed to confirm these findings. Copyright © 2008 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/92045
ISSN
2015 Impact Factor: 2.908
2015 SCImago Journal Rankings: 1.804
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Yen_HK
dc.contributor.authorGuo, JJen_HK
dc.contributor.authorPatel, NCen_HK
dc.date.accessioned2010-09-17T10:34:27Z-
dc.date.available2010-09-17T10:34:27Z-
dc.date.issued2009en_HK
dc.identifier.citationPharmacoepidemiology and Drug Safety, 2009, v. 18 n. 3, p. 196-202en_HK
dc.identifier.issn1053-8569en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92045-
dc.description.abstractObjective: This study aimed to determine whether the degree of serotonin (5-HT) reuptake inhibition affects risk of hemorrhagic stroke associated with antidepressant use in patients with depression. Method: A population-based, nested case-control study was performed using a managed care medical claims database. Ninety two depressed patients with a diagnosis of hemorrhagic stroke were identified and matched with 552 controls by age, sex, and year of index date of depression (IDD). Diagnoses of depression, hemorrhagic stroke, and other medical comorbidities were identified using ICD-9 codes. Antidepressants were classified as high, medium, or low reuptake inhibition based on their affinities for the 5-HT reuptake transporter, determined using their respective equilibrium dissociation constants (KD; high: KD < 1 nM; medium: 1 ≤ KD < 10 nM; low: KD ≥ 10 nM). Conditional logistic regression analysis was performed to estimate the crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of the risk of hemorrhagic stroke. Results: Compared to non-users of antidepressants, risk of hemorrhagic stroke did not significantly differ between patients who had ever used antidepressants with high (OR=.82; 95% CI=.44-1.55), medium (OR=0.93; 95% CI=0.37\2.31), or low (OR=0.38; 95% CI=0.11-1.41) 5-HTT inhibition. Conclusion: Risk of hemorrhagic stroke associated with antidepressant use may not be related to an antidepressant's degree of 5-HT reuptake inhibition. Given the limitations of this study, additional studies are needed to confirm these findings. Copyright © 2008 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/5669en_HK
dc.relation.ispartofPharmacoepidemiology and Drug Safetyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleHemorrhagic stroke associated with antidepressant use in patients with depression: Does degree of serotonin reuptake inhibition matter?en_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pds.1699en_HK
dc.identifier.pmid19115419-
dc.identifier.scopuseid_2-s2.0-65249144663en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65249144663&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume18en_HK
dc.identifier.issue3en_HK
dc.identifier.spage196en_HK
dc.identifier.epage202en_HK
dc.identifier.eissn1099-1557-
dc.identifier.isiWOS:000264371300003-

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