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Article: Effect of deguelin on expression of nup98 in K562 cells

TitleEffect of deguelin on expression of nup98 in K562 cells
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2007
Citation
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, 2007, v. 15 n. 1, p. 25-28 How to Cite?
AbstractThe study was purposed to investigate the effect of deguelin on expression of nucleoporin 98 (nup98) in leukemia K562 cells. MTT assay was used to assess the effects of deguelin on cell proliferation. FCM and RT-PCR were used to analyze the changes of nup98 mRNA and protein in K562 cells after treating with deguelin. The results showed that deguelin inhibited the proliferation of K562 cells in a time- and dose-dependent manner; mean fluorescence intensity of nup98 in blank group (34.22 +/- 1.63) was significantly higher than that in control group (2.83 +/- 0.02, P < 0.01), 10 nmol/L deguelin could significantly inhibit the expression of nup98 protein; 10 nmol/L could not inhibit the expression of nup98 mRNA, 20, 40, 80, 160 nmol/L deguelin could significantly inhibit the expression of nup98 mRNA in a dose-dependant manner. It is concluded that deguelin inhibits the proliferation of K562 cell through inhibiting the expression of nup98, and may be considered as a new target for therapy of acute leukemia.
Persistent Identifierhttp://hdl.handle.net/10722/92044
ISSN
2015 SCImago Journal Rankings: 0.134

 

DC FieldValueLanguage
dc.contributor.authorWu, QLen_HK
dc.contributor.authorChen, Yen_HK
dc.contributor.authorChen, WHen_HK
dc.contributor.authorHe, Jen_HK
dc.date.accessioned2010-09-17T10:34:26Z-
dc.date.available2010-09-17T10:34:26Z-
dc.date.issued2007en_HK
dc.identifier.citationZhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, 2007, v. 15 n. 1, p. 25-28en_HK
dc.identifier.issn1009-2137en_HK
dc.identifier.urihttp://hdl.handle.net/10722/92044-
dc.description.abstractThe study was purposed to investigate the effect of deguelin on expression of nucleoporin 98 (nup98) in leukemia K562 cells. MTT assay was used to assess the effects of deguelin on cell proliferation. FCM and RT-PCR were used to analyze the changes of nup98 mRNA and protein in K562 cells after treating with deguelin. The results showed that deguelin inhibited the proliferation of K562 cells in a time- and dose-dependent manner; mean fluorescence intensity of nup98 in blank group (34.22 +/- 1.63) was significantly higher than that in control group (2.83 +/- 0.02, P < 0.01), 10 nmol/L deguelin could significantly inhibit the expression of nup98 protein; 10 nmol/L could not inhibit the expression of nup98 mRNA, 20, 40, 80, 160 nmol/L deguelin could significantly inhibit the expression of nup98 mRNA in a dose-dependant manner. It is concluded that deguelin inhibits the proliferation of K562 cell through inhibiting the expression of nup98, and may be considered as a new target for therapy of acute leukemia.en_HK
dc.languageengen_HK
dc.relation.ispartofZhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleEffect of deguelin on expression of nup98 in K562 cellsen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, Y:ychenc@hkucc.hku.hken_HK
dc.identifier.authorityChen, Y=rp1318en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid17490514-
dc.identifier.scopuseid_2-s2.0-35548951009en_HK
dc.identifier.volume15en_HK
dc.identifier.issue1en_HK
dc.identifier.spage25en_HK
dc.identifier.epage28en_HK

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