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Article: SNAP-25 is also an iron-sulfur protein

TitleSNAP-25 is also an iron-sulfur protein
Authors
KeywordsIron-sulfur cluster
Palmitoylation
SNAP-25
SNARE
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
Febs Letters, 2008, v. 582 n. 10, p. 1431-1436 How to Cite?
AbstractSNAP-25 has a cysteine cluster located at its linker domain. In vivo, the cysteine residues in this cluster can be palmitoylated, and the hydrophobic palmitate molecules can target SNAP-25 to the presynaptic membrane. Here, we report that the SNAP-25a expressed in Escherichia coli is also an iron-sulfur protein binding an iron-sulfur cluster using the cysteine residues in its cysteine cluster. Therefore, SNAP-25a uses the same cysteine residues to bind two different prosthetic groups (iron-sulfur cluster and palmitate). Because the binding sites of these two prosthetic groups overlap, we suggest that these two modifications occur at different times, and probably at different places in the cell. © 2008 Federation of European Biochemical Societies.
Persistent Identifierhttp://hdl.handle.net/10722/91939
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, Qen_HK
dc.contributor.authorHong, Xen_HK
dc.contributor.authorHao, Qen_HK
dc.date.accessioned2010-09-17T10:31:07Z-
dc.date.available2010-09-17T10:31:07Z-
dc.date.issued2008en_HK
dc.identifier.citationFebs Letters, 2008, v. 582 n. 10, p. 1431-1436en_HK
dc.identifier.issn0014-5793en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91939-
dc.description.abstractSNAP-25 has a cysteine cluster located at its linker domain. In vivo, the cysteine residues in this cluster can be palmitoylated, and the hydrophobic palmitate molecules can target SNAP-25 to the presynaptic membrane. Here, we report that the SNAP-25a expressed in Escherichia coli is also an iron-sulfur protein binding an iron-sulfur cluster using the cysteine residues in its cysteine cluster. Therefore, SNAP-25a uses the same cysteine residues to bind two different prosthetic groups (iron-sulfur cluster and palmitate). Because the binding sites of these two prosthetic groups overlap, we suggest that these two modifications occur at different times, and probably at different places in the cell. © 2008 Federation of European Biochemical Societies.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_HK
dc.relation.ispartofFEBS Lettersen_HK
dc.subjectIron-sulfur clusteren_HK
dc.subjectPalmitoylationen_HK
dc.subjectSNAP-25en_HK
dc.subjectSNAREen_HK
dc.titleSNAP-25 is also an iron-sulfur proteinen_HK
dc.typeArticleen_HK
dc.identifier.emailHao, Q: qhao@hku.hken_HK
dc.identifier.authorityHao, Q=rp01332en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.febslet.2008.03.028en_HK
dc.identifier.pmid18375205-
dc.identifier.scopuseid_2-s2.0-42049090792en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42049090792&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume582en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1431en_HK
dc.identifier.epage1436en_HK
dc.identifier.isiWOS:000258005200007-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridHuang, Q=7403634448en_HK
dc.identifier.scopusauthoridHong, X=7201551709en_HK
dc.identifier.scopusauthoridHao, Q=7102508868en_HK

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