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Article: Macromolecular phasing
Title | Macromolecular phasing |
---|---|
Authors | |
Keywords | Crystallography Mathematical Models Molecular Structure Optical Resolving Power Probability Distributions X Ray Diffraction Analysis |
Issue Date | 2006 |
Publisher | American Institute of Physics. The Journal's web site is located at http://www.physicstoday.com/pt |
Citation | Physics Today, 2006, v. 59 n. 3, p. 46-52 How to Cite? |
Abstract | Several techniques allow crystallographers to reconstruct large molecular structures after recovering the phases that are lost in x-ray diffraction patterns. Direct mathematical methods combine an overdetermined number of intensity measurements with a probability distribution of possible phases. Improvements in modern direct methods and other algorithms have allowed crystallographers to find large numbers of anomalous atom sites in large selenoprotein structures. Several techniques are being proposed to overcome the radiation damage problem for biological specimens and allow crystallographers to get close to atomic resolution. |
Persistent Identifier | http://hdl.handle.net/10722/91932 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.383 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shen, Q | en_HK |
dc.contributor.author | Hao, Q | en_HK |
dc.contributor.author | Gruner, SM | en_HK |
dc.date.accessioned | 2010-09-17T10:30:55Z | - |
dc.date.available | 2010-09-17T10:30:55Z | - |
dc.date.issued | 2006 | en_HK |
dc.identifier.citation | Physics Today, 2006, v. 59 n. 3, p. 46-52 | - |
dc.identifier.issn | 0031-9228 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/91932 | - |
dc.description.abstract | Several techniques allow crystallographers to reconstruct large molecular structures after recovering the phases that are lost in x-ray diffraction patterns. Direct mathematical methods combine an overdetermined number of intensity measurements with a probability distribution of possible phases. Improvements in modern direct methods and other algorithms have allowed crystallographers to find large numbers of anomalous atom sites in large selenoprotein structures. Several techniques are being proposed to overcome the radiation damage problem for biological specimens and allow crystallographers to get close to atomic resolution. | en_HK |
dc.language | eng | en_HK |
dc.publisher | American Institute of Physics. The Journal's web site is located at http://www.physicstoday.com/pt | en_HK |
dc.relation.ispartof | Physics Today | en_HK |
dc.subject | Crystallography | en_HK |
dc.subject | Mathematical Models | en_HK |
dc.subject | Molecular Structure | en_HK |
dc.subject | Optical Resolving Power | en_HK |
dc.subject | Probability Distributions | en_HK |
dc.subject | X Ray Diffraction Analysis | en_HK |
dc.title | Macromolecular phasing | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Hao, Q: qhao@hku.hk | en_HK |
dc.identifier.authority | Hao, Q=rp01332 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1063/1.2195315 | en_HK |
dc.identifier.scopus | eid_2-s2.0-33644624362 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33644624362&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 59 | en_HK |
dc.identifier.issue | 3 | en_HK |
dc.identifier.spage | 46 | en_HK |
dc.identifier.epage | 52 | en_HK |
dc.identifier.isi | WOS:000235781000018 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Shen, Q=7402933087 | en_HK |
dc.identifier.scopusauthorid | Hao, Q=7102508868 | en_HK |
dc.identifier.scopusauthorid | Gruner, SM=7102958350 | en_HK |
dc.identifier.issnl | 0031-9228 | - |