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Article: Structural study of DNA condensation induced by novel phosphorylcholine- based copolymers for gene delivery and relevance to DNA protection

TitleStructural study of DNA condensation induced by novel phosphorylcholine- based copolymers for gene delivery and relevance to DNA protection
Authors
Chim, YTALam, JKWMa, YArmes, SPLewis, ALRoberts, CJStolnik, STendler, SJBDavies, MC
KeywordsChemicals And Cas Registry Numbers
Issue Date2005
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/langmuir
Citation
Langmuir, 2005, v. 21 n. 8, p. 3591-3598 How to Cite?
DOI: http://dx.doi.org/10.1021/la047480i
AbstractThe morphologies of DNA complexes obtained using the diblock copolymer series DMA XMPC 30 using transmission electron microscopy (TEM) and liquid atomic force microscopy (AFM) was analyzed. Enzymatic degradation assays revealed that only the DMA homopolymer provided effective DNA protection against DNase I degradation. TEM study analyzed that the morphology of the complexes changes from loosely condensed structures to highly condensed rods, torroids and oval shaped particles as the DMA moiety increases. For DMA 40-MPC 30 and DMA 60MPC 30 complexes, gel electrophoretic and TEM data indicated high levels of DNA condensation.
Persistent Identifierhttp://hdl.handle.net/10722/91758
ISSN
0743-7463
2023 Impact Factor: 3.7
2023 SCImago Journal Rankings: 0.786
ISI Accession Number ID
WOS:000228218700056
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorChim, YTAen_HK
dc.contributor.authorLam, JKWen_HK
dc.contributor.authorMa, Yen_HK
dc.contributor.authorArmes, SPen_HK
dc.contributor.authorLewis, ALen_HK
dc.contributor.authorRoberts, CJen_HK
dc.contributor.authorStolnik, Sen_HK
dc.contributor.authorTendler, SJBen_HK
dc.contributor.authorDavies, MCen_HK
dc.date.accessioned2010-09-17T10:25:42Z-
dc.date.available2010-09-17T10:25:42Z-
dc.date.issued2005en_HK
dc.identifier.citationLangmuir, 2005, v. 21 n. 8, p. 3591-3598en_HK
dc.identifier.issn0743-7463en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91758-
dc.description.abstractThe morphologies of DNA complexes obtained using the diblock copolymer series DMA XMPC 30 using transmission electron microscopy (TEM) and liquid atomic force microscopy (AFM) was analyzed. Enzymatic degradation assays revealed that only the DMA homopolymer provided effective DNA protection against DNase I degradation. TEM study analyzed that the morphology of the complexes changes from loosely condensed structures to highly condensed rods, torroids and oval shaped particles as the DMA moiety increases. For DMA 40-MPC 30 and DMA 60MPC 30 complexes, gel electrophoretic and TEM data indicated high levels of DNA condensation.en_HK
dc.languageengen_HK
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/langmuiren_HK
dc.relation.ispartofLangmuiren_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleStructural study of DNA condensation induced by novel phosphorylcholine- based copolymers for gene delivery and relevance to DNA protectionen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, JKW: jkwlam@hku.hken_HK
dc.identifier.authorityLam, JKW=rp01346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/la047480ien_HK
dc.identifier.pmid15807606-
dc.identifier.scopuseid_2-s2.0-17444417489en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17444417489&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue8en_HK
dc.identifier.spage3591en_HK
dc.identifier.epage3598en_HK
dc.identifier.isiWOS:000228218700056-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChim, YTA=8404243800en_HK
dc.identifier.scopusauthoridLam, JKW=8404243000en_HK
dc.identifier.scopusauthoridMa, Y=7404701499en_HK
dc.identifier.scopusauthoridArmes, SP=7103125898en_HK
dc.identifier.scopusauthoridLewis, AL=35305215700en_HK
dc.identifier.scopusauthoridRoberts, CJ=35474276800en_HK
dc.identifier.scopusauthoridStolnik, S=35515143300en_HK
dc.identifier.scopusauthoridTendler, SJB=7006271098en_HK
dc.identifier.scopusauthoridDavies, MC=7404208164en_HK
dc.identifier.issnl0743-7463-

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