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Article: Subacute sclerosing panencephalitis in children: Prevalence in South China

TitleSubacute sclerosing panencephalitis in children: Prevalence in South China
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pedneu
Citation
Pediatric Neurology, 2004, v. 31 n. 1, p. 46-51 How to Cite?
AbstractThis investigation reports the prevalence and clinical profile of subacute sclerosing panencephalitis in two developed cities of southern China. A territory-wide survey was conducted to identify all subacute sclerosing panencephalitis cases diagnosed during 1988-2002 in Hong Kong and Macau. Altogether, 10 cases (male:female = 7:3) were identified of whom six were still alive. The prevalence rate of subacute sclerosing panencephalitis in Hong Kong and Macau in 2002 was 1 per million total population or 5.5 per million children. The mean age of presentation was 9.4 years (range = 4-14 years). Presenting features included myoclonus (60%), deterioration in school performance (30%), and transient visual impairment (10%). The clinical course was highly variable. Most had subacute course, but two deteriorated rapidly and died within 6 months. Seven children had measles infection, and the majority of infection (86%) occurred during the world measles epidemic in 1988. The mean interval between measles infection and onset of subacute sclerosing panencephalitis was 6.5 years (range = 3-11 years). There has been an increasing trend of subacute sclerosing panencephalitis in southern China after the measles outbreak in 1988. Active surveillance of subacute sclerosing panencephalitis for those with measles infection during the 1988 outbreak is necessary to conduct multicenter drug trials for this devastating disease. © 2004 by Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/91738
ISSN
2015 Impact Factor: 1.866
2015 SCImago Journal Rankings: 0.819
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIp, Pen_HK
dc.contributor.authorChung, BHYen_HK
dc.contributor.authorWong, VCNen_HK
dc.contributor.authorChan, KYen_HK
dc.date.accessioned2010-09-17T10:24:57Z-
dc.date.available2010-09-17T10:24:57Z-
dc.date.issued2004en_HK
dc.identifier.citationPediatric Neurology, 2004, v. 31 n. 1, p. 46-51en_HK
dc.identifier.issn0887-8994en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91738-
dc.description.abstractThis investigation reports the prevalence and clinical profile of subacute sclerosing panencephalitis in two developed cities of southern China. A territory-wide survey was conducted to identify all subacute sclerosing panencephalitis cases diagnosed during 1988-2002 in Hong Kong and Macau. Altogether, 10 cases (male:female = 7:3) were identified of whom six were still alive. The prevalence rate of subacute sclerosing panencephalitis in Hong Kong and Macau in 2002 was 1 per million total population or 5.5 per million children. The mean age of presentation was 9.4 years (range = 4-14 years). Presenting features included myoclonus (60%), deterioration in school performance (30%), and transient visual impairment (10%). The clinical course was highly variable. Most had subacute course, but two deteriorated rapidly and died within 6 months. Seven children had measles infection, and the majority of infection (86%) occurred during the world measles epidemic in 1988. The mean interval between measles infection and onset of subacute sclerosing panencephalitis was 6.5 years (range = 3-11 years). There has been an increasing trend of subacute sclerosing panencephalitis in southern China after the measles outbreak in 1988. Active surveillance of subacute sclerosing panencephalitis for those with measles infection during the 1988 outbreak is necessary to conduct multicenter drug trials for this devastating disease. © 2004 by Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pedneuen_HK
dc.relation.ispartofPediatric Neurologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.titleSubacute sclerosing panencephalitis in children: Prevalence in South Chinaen_HK
dc.typeArticleen_HK
dc.identifier.emailIp, P:patricip@hku.hken_HK
dc.identifier.emailChung, BHY:bhychung@hku.hken_HK
dc.identifier.emailWong, VCN:vcnwong@hku.hken_HK
dc.identifier.authorityIp, P=rp01337en_HK
dc.identifier.authorityChung, BHY=rp00473en_HK
dc.identifier.authorityWong, VCN=rp00334en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pediatrneurol.2003.11.010en_HK
dc.identifier.pmid15246492-
dc.identifier.scopuseid_2-s2.0-3142611062en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3142611062&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume31en_HK
dc.identifier.issue1en_HK
dc.identifier.spage46en_HK
dc.identifier.epage51en_HK
dc.identifier.isiWOS:000222927500009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridIp, P=7003622681en_HK
dc.identifier.scopusauthoridChung, BHY=7203043997en_HK
dc.identifier.scopusauthoridWong, VCN=7202525632en_HK
dc.identifier.scopusauthoridChan, KY=36985741000en_HK

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