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Article: Prevention of β-thalassemia major by antenatal screening in Hong Kong

TitlePrevention of β-thalassemia major by antenatal screening in Hong Kong
Authors
Keywordsβ-thalassemia
Antenatal screening
Prevention
Issue Date1998
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08880018.asp
Citation
Pediatric Hematology And Oncology, 1998, v. 15 n. 3, p. 249-254 How to Cite?
AbstractThe thalassemias are common in Hong Kong. One of the severe forms, β- thalassemia major, has been preventable locally by antenatal screening since 1983. Yet new patients are still being diagnosed. In this retrospective study, 34 children with severe β-thalassemia syndromes were diagnosed in two major public hospitals between 1990 and 1996. They included one pair of identical twins and two pairs of siblings. Twenty-seven (79%) had homozygous β-thalassemia and seven (21%) had β E thalassemia. All but four (12%) were transfusion dependent. Fifty-five (89%) parents had been evaluated for their thalassemia status. Forty-eight had β-thalassemia traits and seven were hemoglobin E carriers. The reasons for the birth of these children with severe β-thalassemia syndromes were (1) late or no antenatal visit (n = 8, 24.2%), including three cross-border deliveries in which the pregnant mothers came from mainland China to Hong Kong for confinement, (2) lack of maternal screening (n = 13, 39.4%), (3) lack of paternal screening (n = 7, 21.2%), (4) parental refusal (n = 3, 9.1%), and (5) unknown (n = 2, 6.1%). These findings suggest that several factors undermine the effectiveness of antenatal screening for prevention of thalassemias. Many medical practitioners and the general public are still not aware of the screening procedures. The migration of population from mainland China to Hong Kong may result in the birth of many more children with β-thalassemia major.
Persistent Identifierhttp://hdl.handle.net/10722/91737
ISSN
2015 Impact Factor: 1.09
2015 SCImago Journal Rankings: 0.473
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, ACWen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorWong, KWen_HK
dc.contributor.authorCheng, MYen_HK
dc.contributor.authorIp, Pen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorSo, KTen_HK
dc.date.accessioned2010-09-17T10:24:56Z-
dc.date.available2010-09-17T10:24:56Z-
dc.date.issued1998en_HK
dc.identifier.citationPediatric Hematology And Oncology, 1998, v. 15 n. 3, p. 249-254en_HK
dc.identifier.issn0888-0018en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91737-
dc.description.abstractThe thalassemias are common in Hong Kong. One of the severe forms, β- thalassemia major, has been preventable locally by antenatal screening since 1983. Yet new patients are still being diagnosed. In this retrospective study, 34 children with severe β-thalassemia syndromes were diagnosed in two major public hospitals between 1990 and 1996. They included one pair of identical twins and two pairs of siblings. Twenty-seven (79%) had homozygous β-thalassemia and seven (21%) had β E thalassemia. All but four (12%) were transfusion dependent. Fifty-five (89%) parents had been evaluated for their thalassemia status. Forty-eight had β-thalassemia traits and seven were hemoglobin E carriers. The reasons for the birth of these children with severe β-thalassemia syndromes were (1) late or no antenatal visit (n = 8, 24.2%), including three cross-border deliveries in which the pregnant mothers came from mainland China to Hong Kong for confinement, (2) lack of maternal screening (n = 13, 39.4%), (3) lack of paternal screening (n = 7, 21.2%), (4) parental refusal (n = 3, 9.1%), and (5) unknown (n = 2, 6.1%). These findings suggest that several factors undermine the effectiveness of antenatal screening for prevention of thalassemias. Many medical practitioners and the general public are still not aware of the screening procedures. The migration of population from mainland China to Hong Kong may result in the birth of many more children with β-thalassemia major.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/08880018.aspen_HK
dc.relation.ispartofPediatric Hematology and Oncologyen_HK
dc.rightsPediatric Hematology & Oncology. Copyright © Informa Healthcare.-
dc.subjectβ-thalassemiaen_HK
dc.subjectAntenatal screeningen_HK
dc.subjectPreventionen_HK
dc.titlePrevention of β-thalassemia major by antenatal screening in Hong Kongen_HK
dc.typeArticleen_HK
dc.identifier.emailIp, P:patricip@hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityIp, P=rp01337en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9615323-
dc.identifier.scopuseid_2-s2.0-0031865889en_HK
dc.identifier.hkuros31553-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031865889&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue3en_HK
dc.identifier.spage249en_HK
dc.identifier.epage254en_HK
dc.identifier.isiWOS:000073796100009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLee, ACW=7405631431en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridWong, KW=34980167700en_HK
dc.identifier.scopusauthoridCheng, MY=36833893800en_HK
dc.identifier.scopusauthoridIp, P=7003622681en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridSo, KT=7102648548en_HK

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