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Article: Quasispecies of the D225G substitution in the hemagglutinin of pandemic influenza A(H1N1) 2009 virus from patients with severe disease in Hong Kong, China

TitleQuasispecies of the D225G substitution in the hemagglutinin of pandemic influenza A(H1N1) 2009 virus from patients with severe disease in Hong Kong, China
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 2010, v. 201 n. 10, p. 1517-1521 How to Cite?
AbstractThe D225G (aspartic acid to glycine) substitution in the hemagglutinin of H1N1 influenza virus may alter its receptor-binding specificity. Direct analysis of polymorphisms in 126 amino acids spanning the receptor-binding site in the hemagglutinin of pandemic H1N1 2009 virus from 117 clinical specimens in Hong Kong found the D225G substitution for 7 (12.5%) of 57 patients with severe disease and for 0 (0%) of 60 patients with mild disease. D225G quasispecies were identified mainly in endotracheal aspirate samples and were identified less frequently in nasopharyngeal aspirate samples from patients with severe disease. Continuous monitoring of the prevalence and tissue tropism of this variant during its circulation among humans is important. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/91726
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
Funding AgencyGrant Number
Providence Foundation Limited
Research Fund for the Control of Infectious Diseases of the Food and Health Bureau, Hong Kong Special Administrative Region
Research Grants Council of the Hong Kong Special Administrative Region7488/05M
7500/06M
Area of Excellence Scheme of the University Grants CommitteeAoE/M-12/06
University of Hong Kong
Clinical Infectious Diseases Research Endowment Fund
Funding Information:

Providence Foundation Limited (in memory of the late Dr Lui Hac Minh); Research Fund for the Control of Infectious Diseases of the Food and Health Bureau, Hong Kong Special Administrative Region; Research Grants Council of the Hong Kong Special Administrative Region (grants 7488/05M and 7500/06M); Area of Excellence Scheme of the University Grants Committee (grant AoE/M-12/06); University Development Fund 2001-2002 (First Round) of the University of Hong Kong; Clinical Infectious Diseases Research Endowment Fund (from Ms Teresa Wong On Yik).

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorChen, Hen_HK
dc.contributor.authorWen, Xen_HK
dc.contributor.authorTo, KKWen_HK
dc.contributor.authorWang, Pen_HK
dc.contributor.authorTse, Hen_HK
dc.contributor.authorChan, JFWen_HK
dc.contributor.authorTsoi, HWen_HK
dc.contributor.authorFung, KSCen_HK
dc.contributor.authorTse, CWSen_HK
dc.contributor.authorLee, RAen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2010-09-17T10:24:31Z-
dc.date.available2010-09-17T10:24:31Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Infectious Diseases, 2010, v. 201 n. 10, p. 1517-1521en_HK
dc.identifier.issn0022-1899en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91726-
dc.description.abstractThe D225G (aspartic acid to glycine) substitution in the hemagglutinin of H1N1 influenza virus may alter its receptor-binding specificity. Direct analysis of polymorphisms in 126 amino acids spanning the receptor-binding site in the hemagglutinin of pandemic H1N1 2009 virus from 117 clinical specimens in Hong Kong found the D225G substitution for 7 (12.5%) of 57 patients with severe disease and for 0 (0%) of 60 patients with mild disease. D225G quasispecies were identified mainly in endotracheal aspirate samples and were identified less frequently in nasopharyngeal aspirate samples from patients with severe disease. Continuous monitoring of the prevalence and tissue tropism of this variant during its circulation among humans is important. © 2010 by the Infectious Diseases Society of America. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_HK
dc.relation.ispartofJournal of Infectious Diseasesen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAmino Acid Substitutionen_HK
dc.subject.meshDisease Outbreaksen_HK
dc.subject.meshHemagglutinins - geneticsen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfluenza A Virus, H1N1 Subtype - geneticsen_HK
dc.subject.meshInfluenza, Human - epidemiology - virologyen_HK
dc.titleQuasispecies of the D225G substitution in the hemagglutinin of pandemic influenza A(H1N1) 2009 virus from patients with severe disease in Hong Kong, Chinaen_HK
dc.typeArticleen_HK
dc.identifier.emailChen, H: hlchen@hku.hken_HK
dc.identifier.emailTo, KKW: kelvinto@hkucc.hku.hken_HK
dc.identifier.emailTse, H: htse@hkucc.hku.hken_HK
dc.identifier.emailChan, JFW: jfwchan@hku.hken_HK
dc.identifier.emailTsoi, HW: hwtsoi@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityChen, H=rp00383en_HK
dc.identifier.authorityTo, KKW=rp01384en_HK
dc.identifier.authorityTse, H=rp00519en_HK
dc.identifier.authorityChan, JFW=rp01736en_HK
dc.identifier.authorityTsoi, HW=rp00439en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1086/652661en_HK
dc.identifier.pmid20367331-
dc.identifier.scopuseid_2-s2.0-77951891606en_HK
dc.identifier.hkuros180630-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77951891606&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume201en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1517en_HK
dc.identifier.epage1521en_HK
dc.identifier.eissn1537-6613-
dc.identifier.isiWOS:000276767600011-
dc.publisher.placeUnited Statesen_HK
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridChen, H=26643315400en_HK
dc.identifier.scopusauthoridWen, X=36060825600en_HK
dc.identifier.scopusauthoridTo, KKW=14323807300en_HK
dc.identifier.scopusauthoridWang, P=13907209900en_HK
dc.identifier.scopusauthoridTse, H=7006070596en_HK
dc.identifier.scopusauthoridChan, JFW=24278817900en_HK
dc.identifier.scopusauthoridTsoi, HW=6603822102en_HK
dc.identifier.scopusauthoridFung, KSC=8948874600en_HK
dc.identifier.scopusauthoridTse, CWS=7103295064en_HK
dc.identifier.scopusauthoridLee, RA=7408203830en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.citeulike6972630-

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