File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of antibiotics on the bacterial load of meticillin-resistant Staphylococcus aureus colonisation in anterior nares

TitleEffect of antibiotics on the bacterial load of meticillin-resistant Staphylococcus aureus colonisation in anterior nares
Authors
Keywordsβ-Lactams
Antibiotics
Fluoroquinolones
Meticillin-resistant Staphylococcus aureus
Nasal colonisation
Issue Date2008
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jhin
Citation
Journal Of Hospital Infection, 2008, v. 70 n. 1, p. 27-34 How to Cite?
AbstractPrevalence of hospital-acquired meticillin-resistant Staphylococcus aureus (MRSA) infection or colonisation has been associated with antimicrobial consumption. The impact of antibiotic treatment on nasal colonisation is unknown. We conducted a three-month prospective study of 116 patients with extranasal MRSA infection or colonisation, whose nasal MRSA bacterial loads were determined during and after various antibiotic courses over a period of three weeks. Environmental swabs were also taken from the near patient environment. Concomitant nasal MRSA carriage was observed in 76.7% of extranasal MRSA-colonised or -infected patients. The median nasal MRSA bacterial load increased significantly from 2.78 (range 0-6.15) to 5.30 (range 2.90-8.41) log10 cfu per swab (cfu/swab) (P < 0.001) over 21 days during β-lactam therapy. It also increased from 0 (range 0-4.00) to 4.30 (range 0-7.46) log10 cfu/swab (P = 0.039) over 14 days during fluoroquinolone therapy. Median bacterial loads were significantly higher for β-lactam- and fluoroquinolone-treated patients on day 7 [4.78, range 0-7.30], day 14 [4.30, range 0-7.60] and day 21 [5.30, range 2.90-8.41] than controls not receiving antibiotics (P < 0.05). These loads then decreased by 2-5 log10 cfu/swab 2 weeks after discontinuation of antibiotics. The environment of patients receiving β-lactam agents (relative risk: 3.55; 95% confidence interval: 1.30-9.62; P = 0.018) or fluoroquinolones (4.32; 1.52-12.31; P = 0.008) demonstrated more MRSA contamination than the environment around control patients (0.79; 0.67-0.93; P = 0.002). Patients on β-lactam or fluoroquinolone therapy have increased incidence of MRSA colonisation and higher nasal bacterial loads, and appear to spread their MRSA into the near patient environment. © 2008 The Hospital Infection Society.
Persistent Identifierhttp://hdl.handle.net/10722/91722
ISSN
2015 Impact Factor: 2.655
2015 SCImago Journal Rankings: 1.349
ISI Accession Number ID
Funding AgencyGrant Number
The Croucher Senior Medical Research
Funding Information:

Funding from The Croucher Senior Medical Research Fellowship 2006-2007.

References

 

DC FieldValueLanguage
dc.contributor.authorCheng, VCCen_HK
dc.contributor.authorLi, IWSen_HK
dc.contributor.authorWu, AKLen_HK
dc.contributor.authorTang, BSFen_HK
dc.contributor.authorNg, KHLen_HK
dc.contributor.authorTo, KKWen_HK
dc.contributor.authorTse, Hen_HK
dc.contributor.authorQue, TLen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorYuen, KYen_HK
dc.date.accessioned2010-09-17T10:24:24Z-
dc.date.available2010-09-17T10:24:24Z-
dc.date.issued2008en_HK
dc.identifier.citationJournal Of Hospital Infection, 2008, v. 70 n. 1, p. 27-34en_HK
dc.identifier.issn0195-6701en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91722-
dc.description.abstractPrevalence of hospital-acquired meticillin-resistant Staphylococcus aureus (MRSA) infection or colonisation has been associated with antimicrobial consumption. The impact of antibiotic treatment on nasal colonisation is unknown. We conducted a three-month prospective study of 116 patients with extranasal MRSA infection or colonisation, whose nasal MRSA bacterial loads were determined during and after various antibiotic courses over a period of three weeks. Environmental swabs were also taken from the near patient environment. Concomitant nasal MRSA carriage was observed in 76.7% of extranasal MRSA-colonised or -infected patients. The median nasal MRSA bacterial load increased significantly from 2.78 (range 0-6.15) to 5.30 (range 2.90-8.41) log10 cfu per swab (cfu/swab) (P < 0.001) over 21 days during β-lactam therapy. It also increased from 0 (range 0-4.00) to 4.30 (range 0-7.46) log10 cfu/swab (P = 0.039) over 14 days during fluoroquinolone therapy. Median bacterial loads were significantly higher for β-lactam- and fluoroquinolone-treated patients on day 7 [4.78, range 0-7.30], day 14 [4.30, range 0-7.60] and day 21 [5.30, range 2.90-8.41] than controls not receiving antibiotics (P < 0.05). These loads then decreased by 2-5 log10 cfu/swab 2 weeks after discontinuation of antibiotics. The environment of patients receiving β-lactam agents (relative risk: 3.55; 95% confidence interval: 1.30-9.62; P = 0.018) or fluoroquinolones (4.32; 1.52-12.31; P = 0.008) demonstrated more MRSA contamination than the environment around control patients (0.79; 0.67-0.93; P = 0.002). Patients on β-lactam or fluoroquinolone therapy have increased incidence of MRSA colonisation and higher nasal bacterial loads, and appear to spread their MRSA into the near patient environment. © 2008 The Hospital Infection Society.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jhinen_HK
dc.relation.ispartofJournal of Hospital Infectionen_HK
dc.subjectβ-Lactamsen_HK
dc.subjectAntibioticsen_HK
dc.subjectFluoroquinolonesen_HK
dc.subjectMeticillin-resistant Staphylococcus aureusen_HK
dc.subjectNasal colonisationen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAnti-Bacterial Agents - pharmacologyen_HK
dc.subject.meshAntibiotic Prophylaxisen_HK
dc.subject.meshCarrier State - microbiologyen_HK
dc.subject.meshCluster Analysisen_HK
dc.subject.meshColony Count, Microbialen_HK
dc.subject.meshCross Infection - microbiologyen_HK
dc.subject.meshDNA Fingerprintingen_HK
dc.subject.meshDNA, Bacterial - geneticsen_HK
dc.subject.meshElectrophoresis, Gel, Pulsed-Fielden_HK
dc.subject.meshEnvironmental Microbiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMethicillin Resistanceen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNose - microbiologyen_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshStaphylococcal Infections - microbiologyen_HK
dc.subject.meshStaphylococcus aureus - classification - drug effects - isolation & purificationen_HK
dc.subject.meshTime Factorsen_HK
dc.titleEffect of antibiotics on the bacterial load of meticillin-resistant Staphylococcus aureus colonisation in anterior naresen_HK
dc.typeArticleen_HK
dc.identifier.emailTo, KKW:kelvinto@hkucc.hku.hken_HK
dc.identifier.emailTse, H:hftse@hkucc.hku.hken_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailYuen, KY:kyyuen@hkucc.hku.hken_HK
dc.identifier.authorityTo, KKW=rp01384en_HK
dc.identifier.authorityTse, H=rp00428en_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityYuen, KY=rp00366en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jhin.2008.05.019en_HK
dc.identifier.pmid18632184-
dc.identifier.scopuseid_2-s2.0-48749123068en_HK
dc.identifier.hkuros165740-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-48749123068&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume70en_HK
dc.identifier.issue1en_HK
dc.identifier.spage27en_HK
dc.identifier.epage34en_HK
dc.identifier.isiWOS:000259026100005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheng, VCC=23670479400en_HK
dc.identifier.scopusauthoridLi, IWS=24464179500en_HK
dc.identifier.scopusauthoridWu, AKL=7402998681en_HK
dc.identifier.scopusauthoridTang, BSF=8908243000en_HK
dc.identifier.scopusauthoridNg, KHL=27467782600en_HK
dc.identifier.scopusauthoridTo, KKW=14323807300en_HK
dc.identifier.scopusauthoridTse, H=7006070805en_HK
dc.identifier.scopusauthoridQue, TL=7003786628en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridYuen, KY=36078079100en_HK
dc.identifier.citeulike5888855-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats