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Article: Plasma levels of fibrinogen and C-reactive protein are related to interleukin-6 gene -572C>G polymorphism in subjects with and without hypertension
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TitlePlasma levels of fibrinogen and C-reactive protein are related to interleukin-6 gene -572C>G polymorphism in subjects with and without hypertension
 
AuthorsWong, LYF1
Leung, RYH1
Ong, KL1
Cheung, BMY1
 
KeywordsChemicals And Cas Registry Numbers
 
Issue Date2007
 
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
 
CitationJournal Of Human Hypertension, 2007, v. 21 n. 11, p. 875-882 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.jhh.1002233
 
AbstractHypertension is an important risk factor for cardiovascular diseases. There is increasing evidence suggesting that inflammation is involved in the development of hypertension. Interleukin-6 (IL-6) is an important mediator of inflammatory response and the major regulator of hepatic production of acute phase proteins, such as fibrinogen and C-reactive protein (CRP), which have been associated with hypertension and cardiovascular diseases. Therefore, we studied the association of single nucleotide polymorphism (SNP) in the IL-6 gene (IL6) promoter with plasma levels of fibrinogen, CRP and hypertension. Five hundred and two Hong Kong Chinese subjects (282 normotensives and 220 hypertensives) were recruited. IL-6 gene promoter was examined for polymorphism and the study subjects were genotyped for any SNP identified. The IL6 -572C>G polymorphism (rs1800796) was found with a frequency of 0.23 for the minor G allele. Subjects with the -572G allele had significantly higher plasma fibrinogen (3.06 ± 0.57 vs 2.83 ± 0.60, P = 0.002) and CRP (interquartile range 0.33-1.56 vs 0.12-0.93, P = 0.003) levels than those without. The -572C>G polymorphism was found to be an independent predictor of fibrinogen and CRP levels after adjusting for confounding factors. Plasma concentrations of fibrinogen and CRP correlated with systolic blood pressure. However, the -572C>G genotype frequencies did not differ between hypertensive and normotensive subjects, and there was no association between -572C>G polymorphism and blood pressure. Our results provide evidence that there is a clear genetic influence of IL6 -572C>G polymorphism on plasma levels of fibrinogen and CRP, but this polymorphism does not lead to elevated blood pressure.
 
ISSN0950-9240
2012 Impact Factor: 2.818
2012 SCImago Journal Rankings: 0.898
 
DOIhttp://dx.doi.org/10.1038/sj.jhh.1002233
 
ISI Accession Number IDWOS:000250225800005
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, LYF
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorOng, KL
 
dc.contributor.authorCheung, BMY
 
dc.date.accessioned2010-09-17T10:23:38Z
 
dc.date.available2010-09-17T10:23:38Z
 
dc.date.issued2007
 
dc.description.abstractHypertension is an important risk factor for cardiovascular diseases. There is increasing evidence suggesting that inflammation is involved in the development of hypertension. Interleukin-6 (IL-6) is an important mediator of inflammatory response and the major regulator of hepatic production of acute phase proteins, such as fibrinogen and C-reactive protein (CRP), which have been associated with hypertension and cardiovascular diseases. Therefore, we studied the association of single nucleotide polymorphism (SNP) in the IL-6 gene (IL6) promoter with plasma levels of fibrinogen, CRP and hypertension. Five hundred and two Hong Kong Chinese subjects (282 normotensives and 220 hypertensives) were recruited. IL-6 gene promoter was examined for polymorphism and the study subjects were genotyped for any SNP identified. The IL6 -572C>G polymorphism (rs1800796) was found with a frequency of 0.23 for the minor G allele. Subjects with the -572G allele had significantly higher plasma fibrinogen (3.06 ± 0.57 vs 2.83 ± 0.60, P = 0.002) and CRP (interquartile range 0.33-1.56 vs 0.12-0.93, P = 0.003) levels than those without. The -572C>G polymorphism was found to be an independent predictor of fibrinogen and CRP levels after adjusting for confounding factors. Plasma concentrations of fibrinogen and CRP correlated with systolic blood pressure. However, the -572C>G genotype frequencies did not differ between hypertensive and normotensive subjects, and there was no association between -572C>G polymorphism and blood pressure. Our results provide evidence that there is a clear genetic influence of IL6 -572C>G polymorphism on plasma levels of fibrinogen and CRP, but this polymorphism does not lead to elevated blood pressure.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Human Hypertension, 2007, v. 21 n. 11, p. 875-882 [How to Cite?]
DOI: http://dx.doi.org/10.1038/sj.jhh.1002233
 
dc.identifier.citeulike1302636
 
dc.identifier.doihttp://dx.doi.org/10.1038/sj.jhh.1002233
 
dc.identifier.eissn1476-5527
 
dc.identifier.epage882
 
dc.identifier.hkuros180162
 
dc.identifier.isiWOS:000250225800005
 
dc.identifier.issn0950-9240
2012 Impact Factor: 2.818
2012 SCImago Journal Rankings: 0.898
 
dc.identifier.issue11
 
dc.identifier.pmid17508011
 
dc.identifier.scopuseid_2-s2.0-34848822828
 
dc.identifier.spage875
 
dc.identifier.urihttp://hdl.handle.net/10722/91700
 
dc.identifier.volume21
 
dc.languageeng
 
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/jhh
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Human Hypertension
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshBlood Pressure
 
dc.subject.meshC-Reactive Protein - analysis - physiology
 
dc.subject.meshFemale
 
dc.subject.meshFibrinogen - analysis
 
dc.subject.meshGenotype
 
dc.subject.meshHumans
 
dc.subject.meshHypertension - blood - genetics
 
dc.subject.meshInterleukin-6 - genetics
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.subject.meshPromoter Regions, Genetic
 
dc.subjectChemicals And Cas Registry Numbers
 
dc.titlePlasma levels of fibrinogen and C-reactive protein are related to interleukin-6 gene -572C>G polymorphism in subjects with and without hypertension
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong