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Article: Plasma concentration of brain natriuretic peptide is related to diastolic function in hypertension

TitlePlasma concentration of brain natriuretic peptide is related to diastolic function in hypertension
Authors
Issue Date1997
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP
Citation
Clinical And Experimental Pharmacology And Physiology, 1997, v. 24 n. 12, p. 966-968 How to Cite?
Abstract1. The plasma brain natriuretic peptide (BNP) concentration is elevated in patients with essential hypertension and normal systolic function. This may be related to left ventricular hypertrophy or diastolic dysfunction, both of which commonly occur in hypertension. 2. Echocardiography was performed on 32 patients with newly diagnosed untreated mild-to-moderate hypertension (19 men, 13 women; mean±SD age 51 ± 15 years; diastolic blood pressure 99 ± 12mmHg; systolic blood pressure, 153.2 ± 18.0 mmHg; plasma creatinine 86 ± 15 μmol/L; creatinine clearance 92.2 ± 20.5 mL/min; left ventricular mass index 116 ± 28 g/m2; left ventricular ejection fraction 66 ± 9%). A 15 mL peripheral venous blood sample was obtained at the time of echocardiography for radioimnunoassay of BNP. 3. Sixteen patients had abnormal Doppler transmitral flow (E/A ratio <1) and a higher median plasma BNP concentration compared with those patients with E/A 21 (12.9 vs 5.9 pmol/L, respectively; P = 0.006). The plasma BNP level correlated significantly with E/A ratio (r = -0.50; P = 0.035). Multivariate analysis showed that the E/A ratio is related to plasma BNP, independent of age and blood pressure. 4. Our results suggest that the plasma BNP level is influenced by diastolic dysfunction. Further studies are needed to determine whether assay of plasma BNP helps to identify patients with diastolic dysfunction.
Persistent Identifierhttp://hdl.handle.net/10722/91697
ISSN
2012 Impact Factor: 2.16
2015 SCImago Journal Rankings: 0.944
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.date.accessioned2010-09-17T10:23:32Z-
dc.date.available2010-09-17T10:23:32Z-
dc.date.issued1997en_HK
dc.identifier.citationClinical And Experimental Pharmacology And Physiology, 1997, v. 24 n. 12, p. 966-968en_HK
dc.identifier.issn0305-1870en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91697-
dc.description.abstract1. The plasma brain natriuretic peptide (BNP) concentration is elevated in patients with essential hypertension and normal systolic function. This may be related to left ventricular hypertrophy or diastolic dysfunction, both of which commonly occur in hypertension. 2. Echocardiography was performed on 32 patients with newly diagnosed untreated mild-to-moderate hypertension (19 men, 13 women; mean±SD age 51 ± 15 years; diastolic blood pressure 99 ± 12mmHg; systolic blood pressure, 153.2 ± 18.0 mmHg; plasma creatinine 86 ± 15 μmol/L; creatinine clearance 92.2 ± 20.5 mL/min; left ventricular mass index 116 ± 28 g/m2; left ventricular ejection fraction 66 ± 9%). A 15 mL peripheral venous blood sample was obtained at the time of echocardiography for radioimnunoassay of BNP. 3. Sixteen patients had abnormal Doppler transmitral flow (E/A ratio <1) and a higher median plasma BNP concentration compared with those patients with E/A 21 (12.9 vs 5.9 pmol/L, respectively; P = 0.006). The plasma BNP level correlated significantly with E/A ratio (r = -0.50; P = 0.035). Multivariate analysis showed that the E/A ratio is related to plasma BNP, independent of age and blood pressure. 4. Our results suggest that the plasma BNP level is influenced by diastolic dysfunction. Further studies are needed to determine whether assay of plasma BNP helps to identify patients with diastolic dysfunction.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEPen_HK
dc.relation.ispartofClinical and Experimental Pharmacology and Physiologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshDiastole - physiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHeart Ventricles - anatomy & histology - physiopathologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - blood - physiopathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNatriuretic Peptide, Brainen_HK
dc.subject.meshNerve Tissue Proteins - blooden_HK
dc.subject.meshVentricular Function, Left - physiologyen_HK
dc.titlePlasma concentration of brain natriuretic peptide is related to diastolic function in hypertensionen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9406666-
dc.identifier.scopuseid_2-s2.0-0030864327en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030864327&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue12en_HK
dc.identifier.spage966en_HK
dc.identifier.epage968en_HK
dc.identifier.isiWOS:A1997YJ03600013-
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK

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