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- Publisher Website: 10.1111/j.1440-1681.1997.tb02729.x
- Scopus: eid_2-s2.0-0030864327
- PMID: 9406666
- WOS: WOS:A1997YJ03600013
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Article: Plasma concentration of brain natriuretic peptide is related to diastolic function in hypertension
Title | Plasma concentration of brain natriuretic peptide is related to diastolic function in hypertension |
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Authors | |
Keywords | Brain natriuretic peptide Diastolic dysfunction Hypertension Left ventricular hypertrophy Natriuretic pepytides |
Issue Date | 1997 |
Publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP |
Citation | Clinical And Experimental Pharmacology And Physiology, 1997, v. 24 n. 12, p. 966-968 How to Cite? |
Abstract | 1. The plasma brain natriuretic peptide (BNP) concentration is elevated in patients with essential hypertension and normal systolic function. This may be related to left ventricular hypertrophy or diastolic dysfunction, both of which commonly occur in hypertension. 2. Echocardiography was performed on 32 patients with newly diagnosed untreated mild-to-moderate hypertension (19 men, 13 women; mean±SD age 51 ± 15 years; diastolic blood pressure 99 ± 12mmHg; systolic blood pressure, 153.2 ± 18.0 mmHg; plasma creatinine 86 ± 15 μmol/L; creatinine clearance 92.2 ± 20.5 mL/min; left ventricular mass index 116 ± 28 g/m2; left ventricular ejection fraction 66 ± 9%). A 15 mL peripheral venous blood sample was obtained at the time of echocardiography for radioimnunoassay of BNP. 3. Sixteen patients had abnormal Doppler transmitral flow (E/A ratio <1) and a higher median plasma BNP concentration compared with those patients with E/A 21 (12.9 vs 5.9 pmol/L, respectively; P = 0.006). The plasma BNP level correlated significantly with E/A ratio (r = -0.50; P = 0.035). Multivariate analysis showed that the E/A ratio is related to plasma BNP, independent of age and blood pressure. 4. Our results suggest that the plasma BNP level is influenced by diastolic dysfunction. Further studies are needed to determine whether assay of plasma BNP helps to identify patients with diastolic dysfunction. |
Persistent Identifier | http://hdl.handle.net/10722/91697 |
ISSN | 2023 Impact Factor: 2.4 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Cheung, BMY | en_HK |
dc.date.accessioned | 2010-09-17T10:23:32Z | - |
dc.date.available | 2010-09-17T10:23:32Z | - |
dc.date.issued | 1997 | en_HK |
dc.identifier.citation | Clinical And Experimental Pharmacology And Physiology, 1997, v. 24 n. 12, p. 966-968 | en_HK |
dc.identifier.issn | 0305-1870 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/91697 | - |
dc.description.abstract | 1. The plasma brain natriuretic peptide (BNP) concentration is elevated in patients with essential hypertension and normal systolic function. This may be related to left ventricular hypertrophy or diastolic dysfunction, both of which commonly occur in hypertension. 2. Echocardiography was performed on 32 patients with newly diagnosed untreated mild-to-moderate hypertension (19 men, 13 women; mean±SD age 51 ± 15 years; diastolic blood pressure 99 ± 12mmHg; systolic blood pressure, 153.2 ± 18.0 mmHg; plasma creatinine 86 ± 15 μmol/L; creatinine clearance 92.2 ± 20.5 mL/min; left ventricular mass index 116 ± 28 g/m2; left ventricular ejection fraction 66 ± 9%). A 15 mL peripheral venous blood sample was obtained at the time of echocardiography for radioimnunoassay of BNP. 3. Sixteen patients had abnormal Doppler transmitral flow (E/A ratio <1) and a higher median plasma BNP concentration compared with those patients with E/A 21 (12.9 vs 5.9 pmol/L, respectively; P = 0.006). The plasma BNP level correlated significantly with E/A ratio (r = -0.50; P = 0.035). Multivariate analysis showed that the E/A ratio is related to plasma BNP, independent of age and blood pressure. 4. Our results suggest that the plasma BNP level is influenced by diastolic dysfunction. Further studies are needed to determine whether assay of plasma BNP helps to identify patients with diastolic dysfunction. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEP | en_HK |
dc.relation.ispartof | Clinical and Experimental Pharmacology and Physiology | en_HK |
dc.subject | Brain natriuretic peptide | - |
dc.subject | Diastolic dysfunction | - |
dc.subject | Hypertension | - |
dc.subject | Left ventricular hypertrophy | - |
dc.subject | Natriuretic pepytides | - |
dc.subject.mesh | Adult | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Diastole - physiology | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Heart Ventricles - anatomy & histology - physiopathology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Hypertension - blood - physiopathology | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Natriuretic Peptide, Brain | en_HK |
dc.subject.mesh | Nerve Tissue Proteins - blood | en_HK |
dc.subject.mesh | Ventricular Function, Left - physiology | en_HK |
dc.title | Plasma concentration of brain natriuretic peptide is related to diastolic function in hypertension | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Cheung, BMY:mycheung@hku.hk | en_HK |
dc.identifier.authority | Cheung, BMY=rp01321 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/j.1440-1681.1997.tb02729.x | - |
dc.identifier.pmid | 9406666 | - |
dc.identifier.scopus | eid_2-s2.0-0030864327 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0030864327&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 24 | en_HK |
dc.identifier.issue | 12 | en_HK |
dc.identifier.spage | 966 | en_HK |
dc.identifier.epage | 968 | en_HK |
dc.identifier.isi | WOS:A1997YJ03600013 | - |
dc.publisher.place | Australia | en_HK |
dc.identifier.scopusauthorid | Cheung, BMY=7103294806 | en_HK |
dc.identifier.issnl | 0305-1870 | - |