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Article: Digital blood flow response to body warming, cooling, and rewarming in patients with Raynaud's phenomenon

TitleDigital blood flow response to body warming, cooling, and rewarming in patients with Raynaud's phenomenon
Authors
KeywordsLau, C.S.
University Department Of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, Hong Kong © Copyright 2007 Elsevier B.V., All Rights Reserved.
Issue Date1995
PublisherSage Publications, Inc. The Journal's web site is located at http://ang.sagepub.com
Citation
Angiology, 1995, v. 46 n. 1, p. 1-10 How to Cite?
AbstractAlthough the diagnosis of Raynaud's phenomenon (RP) is usually made easily from a careful history, the assessment of RP severity is difficult, for the vasopastic attacks are not easily induced under experimental conditions. In this study, the laser Doppler flowmetry (LDF) technique was used to quantify digital blood flow, which was standardized by body cooling and warming in patients with RP. Twenty-one healthy subjects and 56 RP patients were studied: 7 had primary RP, 22 had suspected secondary Raynaud's syndrome (susp RS), and 27 had systemic sclerosis (SSc)-associated secondary Raynaud's syndrome (SSc RS). The inherent variability in the acral cutaneous circulation was minimized by whole-body warming and cooling. Digital blood flow values at environmental temperatures of 40°C, 12°C, and after rewarming, to 40°C were recorded, as was the time taken for blood flow to reach 25%, 50%, and 75% of the full effects of whole-body cooling and rewarming. Patients with primary RP and susp RS had normal blood flow values at ambient temperatures of 40°C, 12 °C, and after rewarming to 40 °C when compared with controls, but they had significantly faster vasoconstrictor responses to whole-body cooling, suggesting a heightened sympathetic activity. Additionally, they had slower vasodilator responses with longer 25%(max) response time to whole-body rewarming. Patients with SSc RS had significantly lower blood flow values at 40°C after initial warming and following subsequent rewarming, and despite a normal vasoconstrictor response to cooling, it took longer for them to vasodilate during rewarming, suggesting that poor digital blood flow in these patients may be more related to digital vasculature abnormalities and not an increase in sympathetic activity. In conclusion, our assessment technique can be used to quantify digital blood flow in patients with RP and may be potentially useful in the investigation of the etiologic role of the sympathetic nervous system in RP.
Persistent Identifierhttp://hdl.handle.net/10722/91693
ISSN
2015 Impact Factor: 2.931
2015 SCImago Journal Rankings: 0.598
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, CSen_HK
dc.contributor.authorKhan, Fen_HK
dc.contributor.authorBrown, Ren_HK
dc.contributor.authorMcCallum, Pen_HK
dc.contributor.authorBelch, JJFen_HK
dc.date.accessioned2010-09-17T10:23:26Z-
dc.date.available2010-09-17T10:23:26Z-
dc.date.issued1995en_HK
dc.identifier.citationAngiology, 1995, v. 46 n. 1, p. 1-10en_HK
dc.identifier.issn0003-3197en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91693-
dc.description.abstractAlthough the diagnosis of Raynaud's phenomenon (RP) is usually made easily from a careful history, the assessment of RP severity is difficult, for the vasopastic attacks are not easily induced under experimental conditions. In this study, the laser Doppler flowmetry (LDF) technique was used to quantify digital blood flow, which was standardized by body cooling and warming in patients with RP. Twenty-one healthy subjects and 56 RP patients were studied: 7 had primary RP, 22 had suspected secondary Raynaud's syndrome (susp RS), and 27 had systemic sclerosis (SSc)-associated secondary Raynaud's syndrome (SSc RS). The inherent variability in the acral cutaneous circulation was minimized by whole-body warming and cooling. Digital blood flow values at environmental temperatures of 40°C, 12°C, and after rewarming, to 40°C were recorded, as was the time taken for blood flow to reach 25%, 50%, and 75% of the full effects of whole-body cooling and rewarming. Patients with primary RP and susp RS had normal blood flow values at ambient temperatures of 40°C, 12 °C, and after rewarming to 40 °C when compared with controls, but they had significantly faster vasoconstrictor responses to whole-body cooling, suggesting a heightened sympathetic activity. Additionally, they had slower vasodilator responses with longer 25%(max) response time to whole-body rewarming. Patients with SSc RS had significantly lower blood flow values at 40°C after initial warming and following subsequent rewarming, and despite a normal vasoconstrictor response to cooling, it took longer for them to vasodilate during rewarming, suggesting that poor digital blood flow in these patients may be more related to digital vasculature abnormalities and not an increase in sympathetic activity. In conclusion, our assessment technique can be used to quantify digital blood flow in patients with RP and may be potentially useful in the investigation of the etiologic role of the sympathetic nervous system in RP.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc. The Journal's web site is located at http://ang.sagepub.comen_HK
dc.relation.ispartofAngiologyen_HK
dc.subjectLau, C.S.en_HK
dc.subjectUniversity Department Of Medicine, Queen Mary Hospital, Pokfulam Road, Hong Kong, Hong Kong © Copyright 2007 Elsevier B.V., All Rights Reserved.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshArteriosclerosis - complicationsen_HK
dc.subject.meshBody Temperature - physiologyen_HK
dc.subject.meshConnective Tissue Diseases - complicationsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFingers - blood supplyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLaser-Doppler Flowmetryen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshRaynaud Disease - etiology - physiopathologyen_HK
dc.subject.meshRegional Blood Flowen_HK
dc.subject.meshVasoconstrictionen_HK
dc.subject.meshVasodilationen_HK
dc.titleDigital blood flow response to body warming, cooling, and rewarming in patients with Raynaud's phenomenonen_HK
dc.typeArticleen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7818151-
dc.identifier.scopuseid_2-s2.0-0028833234en_HK
dc.identifier.volume46en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage10en_HK
dc.identifier.isiWOS:A1995QC77900001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridKhan, F=7402008077en_HK
dc.identifier.scopusauthoridBrown, R=8884207200en_HK
dc.identifier.scopusauthoridMcCallum, P=18735431000en_HK
dc.identifier.scopusauthoridBelch, JJF=7101752870en_HK

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