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Article: Adrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharide

TitleAdrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharide
Authors
KeywordsAdrenomedullin
Endotoxin
Gene expression
Heart
Infection/inflammation
Vasculature
Issue Date2005
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/npep
Citation
Neuropeptides, 2005, v. 39 n. 2, p. 73-80 How to Cite?
AbstractTo study the effect of septicaemia, the temporal changes in tissue adrenomedullin (AM) and preproAM mRNA levels were studied in the heart and blood vessels after lipopolysaccharide (LPS) injection. Radioimmunoassay and solution hybridization-RNase protection assays were used to follow the changes in AM and its mRNA levels respectively after intraperitoneal injection of 10 mg/kg LPS in rats. The preproAM mRNA levels increased at 1 h in the right atrium after LPS injection, while the AM contents decreased at 1 h in the left atrium. The preproAM mRNA levels increased at 3 and 6 h in the left ventricle, whereas it increased at 6 h in the right ventricles after LPS injection. There was an increase in preproAM mRNA levels at 1 and 3 h in the mesenteric artery, while AM levels were increased at 1, 3 and 6 h. However, there were no such changes in the thoracic aorta. There were also increases in tumour necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 in the heart, and in the mesenteric artery (TNF-α and IL-1β) and in thoracic aorta (IL-1β and IL-6). The present results suggest that the biosynthesis and secretion of AM may be increased in cardiovascular tissues of rats injected with LPS, and that AM may play multiple roles in inflammation. © 2004 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/91692
ISSN
2015 Impact Factor: 2.726
2015 SCImago Journal Rankings: 1.165
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, YYen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorWong, LYFen_HK
dc.contributor.authorHwang, ISSen_HK
dc.contributor.authorKumana, CRen_HK
dc.contributor.authorTang, Fen_HK
dc.date.accessioned2010-09-17T10:23:25Z-
dc.date.available2010-09-17T10:23:25Z-
dc.date.issued2005en_HK
dc.identifier.citationNeuropeptides, 2005, v. 39 n. 2, p. 73-80en_HK
dc.identifier.issn0143-4179en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91692-
dc.description.abstractTo study the effect of septicaemia, the temporal changes in tissue adrenomedullin (AM) and preproAM mRNA levels were studied in the heart and blood vessels after lipopolysaccharide (LPS) injection. Radioimmunoassay and solution hybridization-RNase protection assays were used to follow the changes in AM and its mRNA levels respectively after intraperitoneal injection of 10 mg/kg LPS in rats. The preproAM mRNA levels increased at 1 h in the right atrium after LPS injection, while the AM contents decreased at 1 h in the left atrium. The preproAM mRNA levels increased at 3 and 6 h in the left ventricle, whereas it increased at 6 h in the right ventricles after LPS injection. There was an increase in preproAM mRNA levels at 1 and 3 h in the mesenteric artery, while AM levels were increased at 1, 3 and 6 h. However, there were no such changes in the thoracic aorta. There were also increases in tumour necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 in the heart, and in the mesenteric artery (TNF-α and IL-1β) and in thoracic aorta (IL-1β and IL-6). The present results suggest that the biosynthesis and secretion of AM may be increased in cardiovascular tissues of rats injected with LPS, and that AM may play multiple roles in inflammation. © 2004 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/npepen_HK
dc.relation.ispartofNeuropeptidesen_HK
dc.subjectAdrenomedullinen_HK
dc.subjectEndotoxinen_HK
dc.subjectGene expressionen_HK
dc.subjectHearten_HK
dc.subjectInfection/inflammationen_HK
dc.subjectVasculatureen_HK
dc.subject.meshAdrenomedullinen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAorta, Thoracic - chemistryen_HK
dc.subject.meshCardiovascular System - chemistry - drug effectsen_HK
dc.subject.meshGene Expressionen_HK
dc.subject.meshInterleukin-1 - analysisen_HK
dc.subject.meshInterleukin-6 - analysisen_HK
dc.subject.meshLipopolysaccharides - toxicityen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMesenteric Arteries - chemistryen_HK
dc.subject.meshMyocardium - chemistryen_HK
dc.subject.meshPeptides - analysis - geneticsen_HK
dc.subject.meshProtein Precursors - geneticsen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshTumor Necrosis Factor-alpha - analysisen_HK
dc.titleAdrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharideen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.npep.2004.11.002en_HK
dc.identifier.pmid15752540-
dc.identifier.scopuseid_2-s2.0-14744299336en_HK
dc.identifier.hkuros104387-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-14744299336&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue2en_HK
dc.identifier.spage73en_HK
dc.identifier.epage80en_HK
dc.identifier.isiWOS:000227863000002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, YY=8293496300en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridWong, LYF=24476809800en_HK
dc.identifier.scopusauthoridHwang, ISS=7201615103en_HK
dc.identifier.scopusauthoridKumana, CR=7005112381en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK

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