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Article: HpaII polymorphism in the atrial natriuretic peptide gene and hypertension

TitleHpaII polymorphism in the atrial natriuretic peptide gene and hypertension
Authors
Issue Date1999
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.html
Citation
American Journal Of Hypertension, 1999, v. 12 n. 5, p. 524-527 How to Cite?
AbstractThis was an association study of genetic polymorphisms to compare the distribution of the genotypes and alleles of the HpaII polymorphism of the atrial natriuretic peptide (ANP) gene in hypertensive patients and normotensive controls. The setting was an outpatient clinic run by a University Department handling referrals from primary care. The patient cohort was composed of 217 subjects, consisting of 109 healthy controls and 108 patients with newly diagnosed or documented hypertension. The genomic DNA was extracted from peripheral blood leukocytes, amplified by polymerase chain reaction, and digested with the restriction enzyme HpaII. H1 and H2 alleles were identified after electrophoresis. The main outcome measures were to identify the frequencies of ANP genotypes and alleles in hypertensive patients and normotensive controls. The H1H1, H1H2, and H2H2 genotypes occurred in 1%, 19%, and 80% of controls and 3%, 18%, and 80% of hypertensive patients, respectively. The frequencies of the H1 and H2 alleles were 0.11 and 0.89 in controls and 0.12 and 0.88 in hypertensive patients. The frequencies of the ANP genotypes and alleles did not differ significantly between controls and hypertensive patients. Our findings differed from previous reports and suggested that this polymorphism is not associated with hypertension in this population.
Persistent Identifierhttp://hdl.handle.net/10722/91688
ISSN
2015 Impact Factor: 3.182
2015 SCImago Journal Rankings: 1.397
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLeung, Ren_HK
dc.contributor.authorShiu, Sen_HK
dc.contributor.authorTan, KCBen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorKumana, CRen_HK
dc.date.accessioned2010-09-17T10:23:22Z-
dc.date.available2010-09-17T10:23:22Z-
dc.date.issued1999en_HK
dc.identifier.citationAmerican Journal Of Hypertension, 1999, v. 12 n. 5, p. 524-527en_HK
dc.identifier.issn0895-7061en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91688-
dc.description.abstractThis was an association study of genetic polymorphisms to compare the distribution of the genotypes and alleles of the HpaII polymorphism of the atrial natriuretic peptide (ANP) gene in hypertensive patients and normotensive controls. The setting was an outpatient clinic run by a University Department handling referrals from primary care. The patient cohort was composed of 217 subjects, consisting of 109 healthy controls and 108 patients with newly diagnosed or documented hypertension. The genomic DNA was extracted from peripheral blood leukocytes, amplified by polymerase chain reaction, and digested with the restriction enzyme HpaII. H1 and H2 alleles were identified after electrophoresis. The main outcome measures were to identify the frequencies of ANP genotypes and alleles in hypertensive patients and normotensive controls. The H1H1, H1H2, and H2H2 genotypes occurred in 1%, 19%, and 80% of controls and 3%, 18%, and 80% of hypertensive patients, respectively. The frequencies of the H1 and H2 alleles were 0.11 and 0.89 in controls and 0.12 and 0.88 in hypertensive patients. The frequencies of the ANP genotypes and alleles did not differ significantly between controls and hypertensive patients. Our findings differed from previous reports and suggested that this polymorphism is not associated with hypertension in this population.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajh/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Hypertensionen_HK
dc.rightsAmerican Journal of Hypertension. Copyright © Elsevier Inc.-
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAllelesen_HK
dc.subject.meshAtrial Natriuretic Factor - geneticsen_HK
dc.subject.meshBlood Pressureen_HK
dc.subject.meshDNA - analysisen_HK
dc.subject.meshDeoxyribonuclease HpaII - geneticsen_HK
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGenetic Markersen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - blood - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPoint Mutationen_HK
dc.subject.meshPolymerase Chain Reactionen_HK
dc.subject.meshPolymorphism, Geneticen_HK
dc.titleHpaII polymorphism in the atrial natriuretic peptide gene and hypertensionen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailTan, KCB:kcbtan@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityTan, KCB=rp00402en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0895-7061(98)00267-2en_HK
dc.identifier.pmid10342792-
dc.identifier.scopuseid_2-s2.0-0033005833en_HK
dc.identifier.hkuros42721-
dc.identifier.hkuros54862-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033005833&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue5en_HK
dc.identifier.spage524en_HK
dc.identifier.epage527en_HK
dc.identifier.isiWOS:000080173600013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLeung, R=7101876102en_HK
dc.identifier.scopusauthoridShiu, S=7005550652en_HK
dc.identifier.scopusauthoridTan, KCB=8082703100en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridKumana, CR=7005112381en_HK

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