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Article: The efficacy of intravitreal vancomycin and dexamethasone in the treatment of experimental Bacillus cereus endophthalmitis

TitleThe efficacy of intravitreal vancomycin and dexamethasone in the treatment of experimental Bacillus cereus endophthalmitis
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2008
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02713683.asp
Citation
Current Eye Research, 2008, v. 33 n. 9, p. 761-768 How to Cite?
AbstractPurpose: Bacillus cereus causes the most virulent and refractory form of endophthalmitis. The authors analyzed effectiveness of intravitreal vancomycin with or without dexamethasone for experimental Bacillus cereus endophthalmitis. Methods: Rabbit eyes were injected intravitreally with 1 × 106 colony-forming units of Bacillus cereus organisms. At 24 hours after injection, eyes were injected intravitreally with 0.1 ml of balanced salt solution (group 1, n = 10), 1 mg vancomycin (group 2, n = 10), and antibiotic plus 0.4 mg dexamethasone (group 3, n = 10). Inflammatory scores were assessed 7 days and 14 days after treatment. Furthermore, histologic grading was carried out at the conclusion of the clinical observations. Results: Eyes treated with vancomycin, with or without dexamethasone at 7 days and 14 days expressed significant less inflammation over iris and vitreous than the control group (p < 0.05). Moreover, eyes treated with vancomycin with dexamethasone showed less inflammation over the conjunctiva and vitreous at 7 days and over the iris and vitreous at 14 days, compared to antibiotic treatment alone (p < 0.05). Additionally, at 14 days, the histopathological changes of eyes treated with vancomycin with dexamethasone had less conjunctival inflammation, mild iridocyclitis, less vitreous cells, and less choroidal vasculitis and retinitis compared to control group and antibiotic treatment alone, respectively (p < 0.05). Conclusion: Intravitreal injection of vancomycin improved the therapeutic outcome of Bacillus cereus endophthalmitis. The addition of dexamethasone to antibiotic treatment provided a therapeutic benefit over antibiotic alone. Copyright © Informa Healthcare USA, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/91682
ISSN
2015 Impact Factor: 2.025
2015 SCImago Journal Rankings: 0.975
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, Fen_HK
dc.contributor.authorKwok, AKHen_HK
dc.contributor.authorCheung, BMYen_HK
dc.date.accessioned2010-09-17T10:23:16Z-
dc.date.available2010-09-17T10:23:16Z-
dc.date.issued2008en_HK
dc.identifier.citationCurrent Eye Research, 2008, v. 33 n. 9, p. 761-768en_HK
dc.identifier.issn0271-3683en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91682-
dc.description.abstractPurpose: Bacillus cereus causes the most virulent and refractory form of endophthalmitis. The authors analyzed effectiveness of intravitreal vancomycin with or without dexamethasone for experimental Bacillus cereus endophthalmitis. Methods: Rabbit eyes were injected intravitreally with 1 × 106 colony-forming units of Bacillus cereus organisms. At 24 hours after injection, eyes were injected intravitreally with 0.1 ml of balanced salt solution (group 1, n = 10), 1 mg vancomycin (group 2, n = 10), and antibiotic plus 0.4 mg dexamethasone (group 3, n = 10). Inflammatory scores were assessed 7 days and 14 days after treatment. Furthermore, histologic grading was carried out at the conclusion of the clinical observations. Results: Eyes treated with vancomycin, with or without dexamethasone at 7 days and 14 days expressed significant less inflammation over iris and vitreous than the control group (p < 0.05). Moreover, eyes treated with vancomycin with dexamethasone showed less inflammation over the conjunctiva and vitreous at 7 days and over the iris and vitreous at 14 days, compared to antibiotic treatment alone (p < 0.05). Additionally, at 14 days, the histopathological changes of eyes treated with vancomycin with dexamethasone had less conjunctival inflammation, mild iridocyclitis, less vitreous cells, and less choroidal vasculitis and retinitis compared to control group and antibiotic treatment alone, respectively (p < 0.05). Conclusion: Intravitreal injection of vancomycin improved the therapeutic outcome of Bacillus cereus endophthalmitis. The addition of dexamethasone to antibiotic treatment provided a therapeutic benefit over antibiotic alone. Copyright © Informa Healthcare USA, Inc.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02713683.aspen_HK
dc.relation.ispartofCurrent Eye Researchen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshAnti-Bacterial Agents - therapeutic useen_HK
dc.subject.meshBacillus cereus - physiologyen_HK
dc.subject.meshChoroid Diseases - drug therapy - pathologyen_HK
dc.subject.meshDexamethasone - therapeutic useen_HK
dc.subject.meshDisease Models, Animalen_HK
dc.subject.meshDrug Therapy, Combinationen_HK
dc.subject.meshEndophthalmitis - drug therapy - pathologyen_HK
dc.subject.meshEye Infections, Bacterial - drug therapy - pathologyen_HK
dc.subject.meshGlucocorticoids - therapeutic useen_HK
dc.subject.meshGram-Positive Bacterial Infections - drug therapy - pathologyen_HK
dc.subject.meshInjectionsen_HK
dc.subject.meshIridocyclitis - drug therapy - pathologyen_HK
dc.subject.meshRabbitsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.subject.meshVancomycin - therapeutic useen_HK
dc.subject.meshVasculitis - drug therapy - pathologyen_HK
dc.subject.meshVitreous Body - drug effects - microbiologyen_HK
dc.titleThe efficacy of intravitreal vancomycin and dexamethasone in the treatment of experimental Bacillus cereus endophthalmitisen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/02713680802344690en_HK
dc.identifier.pmid18798079-
dc.identifier.scopuseid_2-s2.0-51949098463en_HK
dc.identifier.hkuros180065-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-51949098463&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue9en_HK
dc.identifier.spage761en_HK
dc.identifier.epage768en_HK
dc.identifier.eissn1460-2202-
dc.identifier.isiWOS:000259240100004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLiu, F=17233795400en_HK
dc.identifier.scopusauthoridKwok, AKH=7005913424en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK

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