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Article: Do flares of systemic lupus erythematosus decline after menopause?

TitleDo flares of systemic lupus erythematosus decline after menopause?
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1999
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03009742.asp
Citation
Scandinavian Journal Of Rheumatology, 1999, v. 28 n. 6, p. 357-362 How to Cite?
AbstractObjective. To study whether flares of SLE decline after menopause. Method. 34 postmenopausal SLE patients with premenopausal disease onset were studied. The frequency and severity of flares before and after menopause was compared. 17 postmenopausal onset SLE patients were also included for comparison. Result. Flares in postmenopausal SLE patients decreased significantly after menopause (total No. of flares/patient-year before and after menopause were 0.50 ± 0.10 and 0.14 ± 0.05, respectively, p = 0.002). The frequency and proportion of severe flares also dropped significantly. The rate and magnitude of postmenopausal flares in these patients were similar to those of the postmenopausal onset SLE patients, a subset known to run a more benign course. Conclusions. SLE flares less frequently and seriously after menopause. While this may suggest a protective role of hypoestrogenemia against lupus flares, the contribution of other factors like disease duration and effective treatment to this postmenopausal decline of flares cannot be separated from menopause per se. Further studies are needed.
Persistent Identifierhttp://hdl.handle.net/10722/91668
ISSN
2015 Impact Factor: 2.307
2015 SCImago Journal Rankings: 1.125
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMok, CCen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorHo, CTKen_HK
dc.contributor.authorWong, RWSen_HK
dc.date.accessioned2010-09-17T10:23:04Z-
dc.date.available2010-09-17T10:23:04Z-
dc.date.issued1999en_HK
dc.identifier.citationScandinavian Journal Of Rheumatology, 1999, v. 28 n. 6, p. 357-362en_HK
dc.identifier.issn0300-9742en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91668-
dc.description.abstractObjective. To study whether flares of SLE decline after menopause. Method. 34 postmenopausal SLE patients with premenopausal disease onset were studied. The frequency and severity of flares before and after menopause was compared. 17 postmenopausal onset SLE patients were also included for comparison. Result. Flares in postmenopausal SLE patients decreased significantly after menopause (total No. of flares/patient-year before and after menopause were 0.50 ± 0.10 and 0.14 ± 0.05, respectively, p = 0.002). The frequency and proportion of severe flares also dropped significantly. The rate and magnitude of postmenopausal flares in these patients were similar to those of the postmenopausal onset SLE patients, a subset known to run a more benign course. Conclusions. SLE flares less frequently and seriously after menopause. While this may suggest a protective role of hypoestrogenemia against lupus flares, the contribution of other factors like disease duration and effective treatment to this postmenopausal decline of flares cannot be separated from menopause per se. Further studies are needed.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/03009742.aspen_HK
dc.relation.ispartofScandinavian Journal of Rheumatologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge of Onseten_HK
dc.subject.meshAutoantibodies - analysisen_HK
dc.subject.meshAutoantigens - immunologyen_HK
dc.subject.meshChilden_HK
dc.subject.meshEstradiol - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollicle Stimulating Hormone - blooden_HK
dc.subject.meshHumansen_HK
dc.subject.meshLupus Erythematosus, Systemic - epidemiology - physiopathologyen_HK
dc.subject.meshLuteinizing Hormone - blooden_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPostmenopause - metabolismen_HK
dc.subject.meshRemission, Spontaneousen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshRibonucleoproteins, Small Nuclearen_HK
dc.subject.meshRisk Assessmenten_HK
dc.subject.meshsnRNP Core Proteinsen_HK
dc.titleDo flares of systemic lupus erythematosus decline after menopause?en_HK
dc.typeArticleen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10665741-
dc.identifier.scopuseid_2-s2.0-0033403795en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033403795&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue6en_HK
dc.identifier.spage357en_HK
dc.identifier.epage362en_HK
dc.identifier.isiWOS:000084831400007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMok, CC=34668219600en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridHo, CTK=7404652632en_HK
dc.identifier.scopusauthoridWong, RWS=34875928200en_HK

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