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Article: Long-term combination therapy with aspirin and clopidogrel

TitleLong-term combination therapy with aspirin and clopidogrel
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2004
PublisherSage Publications, Inc. The Journal's web site is located at http://cpt.sagepub.com
Citation
Journal Of Cardiovascular Pharmacology And Therapeutics, 2004, v. 9 n. 4, p. 223-225 How to Cite?
AbstractThe possible additive antiplatelet effects of aspirin and clopidogrel have been explored in the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) and Management of Atherothrombosis with Clopidogrel in High Risk Patients (MATCH) studies. To assess the overall absolute beneficial and/or harmful impact of aspirin and clopidogrel combination therapy compared with monotherapy with either drug, we analyzed the results from both trials in terms of number needed to treat per year. Treating between 35 and 204 at-risk patients for 1 year with combination therapy appeared to prevent 1 patient from experiencing an adverse primary cardiovascular outcome; whereas, about 1 in 63 such patients appeared liable to major bleeding during that period. We determined that the evidence to date indicates no overall advantage for combination therapy with anti-platelet drugs in preference to monotherapy.
Persistent Identifierhttp://hdl.handle.net/10722/91664
ISSN
2014 Impact Factor: 2.094
2014 SCImago Journal Rankings: 0.893
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKumana, CRen_HK
dc.contributor.authorCheung, Gen_HK
dc.contributor.authorLauder, IJen_HK
dc.contributor.authorCheung, BMYen_HK
dc.date.accessioned2010-09-17T10:23:00Z-
dc.date.available2010-09-17T10:23:00Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Cardiovascular Pharmacology And Therapeutics, 2004, v. 9 n. 4, p. 223-225en_HK
dc.identifier.issn1074-2484en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91664-
dc.description.abstractThe possible additive antiplatelet effects of aspirin and clopidogrel have been explored in the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) and Management of Atherothrombosis with Clopidogrel in High Risk Patients (MATCH) studies. To assess the overall absolute beneficial and/or harmful impact of aspirin and clopidogrel combination therapy compared with monotherapy with either drug, we analyzed the results from both trials in terms of number needed to treat per year. Treating between 35 and 204 at-risk patients for 1 year with combination therapy appeared to prevent 1 patient from experiencing an adverse primary cardiovascular outcome; whereas, about 1 in 63 such patients appeared liable to major bleeding during that period. We determined that the evidence to date indicates no overall advantage for combination therapy with anti-platelet drugs in preference to monotherapy.en_HK
dc.languageengen_HK
dc.publisherSage Publications, Inc. The Journal's web site is located at http://cpt.sagepub.comen_HK
dc.relation.ispartofJournal of Cardiovascular Pharmacology and Therapeuticsen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAngina, Unstable - drug therapyen_HK
dc.subject.meshArteriosclerosis - drug therapyen_HK
dc.subject.meshAspirin - administration & dosage - adverse effects - therapeutic useen_HK
dc.subject.meshCyclooxygenase Inhibitors - administration & dosage - adverse effects - therapeutic useen_HK
dc.subject.meshDouble-Blind Methoden_HK
dc.subject.meshDrug Administration Scheduleen_HK
dc.subject.meshDrug Therapy, Combinationen_HK
dc.subject.meshHumansen_HK
dc.subject.meshPlacebosen_HK
dc.subject.meshPlatelet Aggregation Inhibitors - administration & dosage - adverse effects - therapeutic useen_HK
dc.subject.meshRandomized Controlled Trials as Topicen_HK
dc.subject.meshRecurrenceen_HK
dc.subject.meshThrombosis - drug therapyen_HK
dc.subject.meshTiclopidine - administration & dosage - adverse effects - analogs & derivatives - therapeutic useen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleLong-term combination therapy with aspirin and clopidogrelen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/107424840400900402en_HK
dc.identifier.pmid15678241-
dc.identifier.scopuseid_2-s2.0-12344307601en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12344307601&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.issue4en_HK
dc.identifier.spage223en_HK
dc.identifier.epage225en_HK
dc.identifier.isiWOS:000226495700002-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridKumana, CR=7005112381en_HK
dc.identifier.scopusauthoridCheung, G=55108882600en_HK
dc.identifier.scopusauthoridLauder, IJ=35564928000en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK

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