Article: Long-term combination therapy with aspirin and clopidogrel

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TitleLong-term combination therapy with aspirin and clopidogrel
AuthorsKumana, CR1
Cheung, G1
Lauder, IJ1
Cheung, BMY1
KeywordsChemicals And Cas Registry Numbers
Issue Date2004
PublisherSage Publications, Inc. The Journal's web site is located at http://cpt.sagepub.com
CitationJournal Of Cardiovascular Pharmacology And Therapeutics, 2004, v. 9 n. 4, p. 223-225 [How to Cite?]
DOI: http://dx.doi.org/10.1177/107424840400900402
AbstractThe possible additive antiplatelet effects of aspirin and clopidogrel have been explored in the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) and Management of Atherothrombosis with Clopidogrel in High Risk Patients (MATCH) studies. To assess the overall absolute beneficial and/or harmful impact of aspirin and clopidogrel combination therapy compared with monotherapy with either drug, we analyzed the results from both trials in terms of number needed to treat per year. Treating between 35 and 204 at-risk patients for 1 year with combination therapy appeared to prevent 1 patient from experiencing an adverse primary cardiovascular outcome; whereas, about 1 in 63 such patients appeared liable to major bleeding during that period. We determined that the evidence to date indicates no overall advantage for combination therapy with anti-platelet drugs in preference to monotherapy.
ISSN1074-2484
2011 Impact Factor: 1.753
2011 SCImago Journal Rankings: 0.129
DOIhttp://dx.doi.org/10.1177/107424840400900402
ISI Accession Number IDWOS:000226495700002
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorKumana, CR
dc.contributor.authorCheung, G
dc.contributor.authorLauder, IJ
dc.contributor.authorCheung, BMY
dc.date.accessioned2010-09-17T10:23:00Z
dc.date.available2010-09-17T10:23:00Z
dc.date.issued2004
dc.description.abstractThe possible additive antiplatelet effects of aspirin and clopidogrel have been explored in the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) and Management of Atherothrombosis with Clopidogrel in High Risk Patients (MATCH) studies. To assess the overall absolute beneficial and/or harmful impact of aspirin and clopidogrel combination therapy compared with monotherapy with either drug, we analyzed the results from both trials in terms of number needed to treat per year. Treating between 35 and 204 at-risk patients for 1 year with combination therapy appeared to prevent 1 patient from experiencing an adverse primary cardiovascular outcome; whereas, about 1 in 63 such patients appeared liable to major bleeding during that period. We determined that the evidence to date indicates no overall advantage for combination therapy with anti-platelet drugs in preference to monotherapy.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Cardiovascular Pharmacology And Therapeutics, 2004, v. 9 n. 4, p. 223-225 [How to Cite?]
DOI: http://dx.doi.org/10.1177/107424840400900402
dc.identifier.doihttp://dx.doi.org/10.1177/107424840400900402
dc.identifier.epage225
dc.identifier.isiWOS:000226495700002
dc.identifier.issn1074-2484
2011 Impact Factor: 1.753
2011 SCImago Journal Rankings: 0.129
dc.identifier.issue4
dc.identifier.pmid15678241
dc.identifier.scopuseid_2-s2.0-12344307601
dc.identifier.spage223
dc.identifier.urihttp://hdl.handle.net/10722/91664
dc.identifier.volume9
dc.languageeng
dc.publisherSage Publications, Inc. The Journal's web site is located at http://cpt.sagepub.com
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Cardiovascular Pharmacology and Therapeutics
dc.relation.referencesReferences in Scopus
dc.subject.meshAngina, Unstable - drug therapy
dc.subject.meshArteriosclerosis - drug therapy
dc.subject.meshAspirin - administration & dosage - adverse effects - therapeutic use
dc.subject.meshCyclooxygenase Inhibitors - administration & dosage - adverse effects - therapeutic use
dc.subject.meshDouble-Blind Method
dc.subject.meshDrug Administration Schedule
dc.subject.meshDrug Therapy, Combination
dc.subject.meshHumans
dc.subject.meshPlacebos
dc.subject.meshPlatelet Aggregation Inhibitors - administration & dosage - adverse effects - therapeutic use
dc.subject.meshRandomized Controlled Trials as Topic
dc.subject.meshRecurrence
dc.subject.meshThrombosis - drug therapy
dc.subject.meshTiclopidine - administration & dosage - adverse effects - analogs & derivatives - therapeutic use
dc.subject.meshTreatment Outcome
dc.subjectChemicals And Cas Registry Numbers
dc.titleLong-term combination therapy with aspirin and clopidogrel
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong