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Article: Increase in adrenomedullin gene expression in the left atrium and ventricle in the two-kidney one-clip renovascular hypertensive rats

TitleIncrease in adrenomedullin gene expression in the left atrium and ventricle in the two-kidney one-clip renovascular hypertensive rats
Authors
Hwang, ISSCheung, BMYTang, F
KeywordsAdrenomedullin
Atria
Plasma
Renovascular hypertension
Ventricles
Issue Date2003
PublisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/npep
Citation
Neuropeptides, 2003, v. 37 n. 4, p. 239-244 How to Cite?
DOI: http://dx.doi.org/10.1016/S0143-4179(03)00052-0
AbstractThe 2-kidney 1-clip rat model was set up by clipping the left renal artery. At 5 weeks after clipping, there was an increase in preproadrenomedullin mRNA levels in both the left atria and the left ventricle. Adrenomedullin (AM) contents, however, increased in the left ventricle but decreased in the left atrium. These changes were not observed at 2 weeks after clipping. There were no changes in AM or preproadrenomedullin mRNA levels in the thoracic aorta and the mesenteric artery, and in plasma AM levels at 2 weeks or 5 weeks after clipping. We concluded that there was an increase in the secretion of AM in the left ventricle and the left atria in the 5 week renovascular hypertensive rat. The lack of change in plasma AM level suggests a paracrine function for the peptide in this setting. © 2003 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/91655
ISSN
0143-4179
2023 Impact Factor: 2.5
2023 SCImago Journal Rankings: 0.716
ISI Accession Number ID
WOS:000184892900005
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorHwang, ISSen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorTang, Fen_HK
dc.date.accessioned2010-09-17T10:22:52Z-
dc.date.available2010-09-17T10:22:52Z-
dc.date.issued2003en_HK
dc.identifier.citationNeuropeptides, 2003, v. 37 n. 4, p. 239-244en_HK
dc.identifier.issn0143-4179en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91655-
dc.description.abstractThe 2-kidney 1-clip rat model was set up by clipping the left renal artery. At 5 weeks after clipping, there was an increase in preproadrenomedullin mRNA levels in both the left atria and the left ventricle. Adrenomedullin (AM) contents, however, increased in the left ventricle but decreased in the left atrium. These changes were not observed at 2 weeks after clipping. There were no changes in AM or preproadrenomedullin mRNA levels in the thoracic aorta and the mesenteric artery, and in plasma AM levels at 2 weeks or 5 weeks after clipping. We concluded that there was an increase in the secretion of AM in the left ventricle and the left atria in the 5 week renovascular hypertensive rat. The lack of change in plasma AM level suggests a paracrine function for the peptide in this setting. © 2003 Elsevier Science Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherChurchill Livingstone. The Journal's web site is located at http://www.elsevier.com/locate/npepen_HK
dc.relation.ispartofNeuropeptidesen_HK
dc.subjectAdrenomedullinen_HK
dc.subjectAtriaen_HK
dc.subjectPlasmaen_HK
dc.subjectRenovascular hypertensionen_HK
dc.subjectVentriclesen_HK
dc.subject.meshAdrenomedullinen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshGene Expression - physiologyen_HK
dc.subject.meshHeart - physiologyen_HK
dc.subject.meshHeart Atria - metabolismen_HK
dc.subject.meshHeart Ventricles - metabolismen_HK
dc.subject.meshHypertension, Renal - physiopathologyen_HK
dc.subject.meshKidney - blood supply - physiopathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPeptides - genetics - metabolismen_HK
dc.subject.meshRNA, Messenger - analysisen_HK
dc.subject.meshRadioimmunoassayen_HK
dc.subject.meshRatsen_HK
dc.subject.meshRats, Sprague-Dawleyen_HK
dc.subject.meshRenal Arteryen_HK
dc.subject.meshSurgical Instrumentsen_HK
dc.titleIncrease in adrenomedullin gene expression in the left atrium and ventricle in the two-kidney one-clip renovascular hypertensive ratsen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailTang, F: ftang@hkucc.hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityTang, F=rp00327en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0143-4179(03)00052-0en_HK
dc.identifier.pmid12906842en_HK
dc.identifier.scopuseid_2-s2.0-0041880711en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0041880711&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume37en_HK
dc.identifier.issue4en_HK
dc.identifier.spage239en_HK
dc.identifier.epage244en_HK
dc.identifier.isiWOS:000184892900005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHwang, ISS=7201615103en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridTang, F=7201979770en_HK
dc.identifier.issnl0143-4179-

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