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Article: Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast

TitleGanoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast
Authors
KeywordsCytokines
Ganoderma lucidum
Inflammation
NF-κB
Rheumatoid arthritis
Synovial fibroblast
Issue Date2007
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177
Citation
Molecular And Cellular Biochemistry, 2007, v. 301 n. 1-2, p. 173-179 How to Cite?
AbstractThe aim of the current study was to elucidate the potential therapeutic effect of Ganoderma lucidum polysaccharide peptide (GL-PP) in rheumatoid arthritis (RA). The effects of GL-PP on cell proliferation and cytokine production were studied in RA synovial fibroblasts (RASF). GL-PP significantly inhibited the proliferation of RASF. Following the incubation with GL-PP, production of interleukin (IL)-6 and monocyte chemoattractant protein (MCP)-1 in RASF were significantly increased as expressed as percentage change from basal values. However, the actual effects were minimal due to the low basal values. When RASF were activated by IL-1β or lipopolysaccharides, IL-8 and MCP-1 production increased many folds. GL-PP significantly suppressed their productions. The inhibitory effects of GL-PP on cytokine production in RASF were at least in part, by inhibiting the nuclear factor-kappa B (NF-κB) transcription pathway. Our results demonstrated that GL-PP had the unique ability to modulate cytokine production in RASF and warrants further investigation into its mechanism of action. © Springer Science+Business Media, LLC 2007.
Persistent Identifierhttp://hdl.handle.net/10722/91647
ISSN
2015 Impact Factor: 2.613
2015 SCImago Journal Rankings: 1.019
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, YWen_HK
dc.contributor.authorYeung, JSLen_HK
dc.contributor.authorChiu, PKYen_HK
dc.contributor.authorTang, WMen_HK
dc.contributor.authorLin, ZBen_HK
dc.contributor.authorMan, RYKen_HK
dc.contributor.authorLau, CSen_HK
dc.date.accessioned2010-09-17T10:22:44Z-
dc.date.available2010-09-17T10:22:44Z-
dc.date.issued2007en_HK
dc.identifier.citationMolecular And Cellular Biochemistry, 2007, v. 301 n. 1-2, p. 173-179en_HK
dc.identifier.issn0300-8177en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91647-
dc.description.abstractThe aim of the current study was to elucidate the potential therapeutic effect of Ganoderma lucidum polysaccharide peptide (GL-PP) in rheumatoid arthritis (RA). The effects of GL-PP on cell proliferation and cytokine production were studied in RA synovial fibroblasts (RASF). GL-PP significantly inhibited the proliferation of RASF. Following the incubation with GL-PP, production of interleukin (IL)-6 and monocyte chemoattractant protein (MCP)-1 in RASF were significantly increased as expressed as percentage change from basal values. However, the actual effects were minimal due to the low basal values. When RASF were activated by IL-1β or lipopolysaccharides, IL-8 and MCP-1 production increased many folds. GL-PP significantly suppressed their productions. The inhibitory effects of GL-PP on cytokine production in RASF were at least in part, by inhibiting the nuclear factor-kappa B (NF-κB) transcription pathway. Our results demonstrated that GL-PP had the unique ability to modulate cytokine production in RASF and warrants further investigation into its mechanism of action. © Springer Science+Business Media, LLC 2007.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0300-8177en_HK
dc.relation.ispartofMolecular and Cellular Biochemistryen_HK
dc.subjectCytokinesen_HK
dc.subjectGanoderma lucidumen_HK
dc.subjectInflammationen_HK
dc.subjectNF-κBen_HK
dc.subjectRheumatoid arthritisen_HK
dc.subjectSynovial fibroblasten_HK
dc.subject.meshArthritis, Rheumatoid - drug therapy - immunology - pathologyen_HK
dc.subject.meshCell Proliferation - drug effectsen_HK
dc.subject.meshCells, Cultureden_HK
dc.subject.meshCytokines - immunologyen_HK
dc.subject.meshFibroblasts - cytology - drug effects - metabolismen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMedicine, Chinese Traditionalen_HK
dc.subject.meshNF-kappa B - metabolismen_HK
dc.subject.meshProteoglycans - pharmacology - therapeutic useen_HK
dc.subject.meshReishi - chemistryen_HK
dc.subject.meshSynovial Membrane - cytologyen_HK
dc.titleGanoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblasten_HK
dc.typeArticleen_HK
dc.identifier.emailChiu, PKY: pkychiu@hkucc.hku.hken_HK
dc.identifier.emailMan, RYK: rykman@hkucc.hku.hken_HK
dc.identifier.emailLau, CS: cslau@hku.hken_HK
dc.identifier.authorityChiu, PKY=rp00379en_HK
dc.identifier.authorityMan, RYK=rp00236en_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11010-006-9409-yen_HK
dc.identifier.pmid17219061-
dc.identifier.scopuseid_2-s2.0-34250156004en_HK
dc.identifier.hkuros151394-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250156004&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume301en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage173en_HK
dc.identifier.epage179en_HK
dc.identifier.eissn1573-4919-
dc.identifier.isiWOS:000247679400018-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, YW=36838962100en_HK
dc.identifier.scopusauthoridYeung, JSL=24482785000en_HK
dc.identifier.scopusauthoridChiu, PKY=7202988127en_HK
dc.identifier.scopusauthoridTang, WM=7403430820en_HK
dc.identifier.scopusauthoridLin, ZB=7404230065en_HK
dc.identifier.scopusauthoridMan, RYK=7004986435en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.citeulike2680292-

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