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Article: Is there a role for antacids in the modern management of peptic ulcers?

TitleIs there a role for antacids in the modern management of peptic ulcers?
Authors
KeywordsAntacids
Duodenal ulcer
Gastric ulcer
Peptic ulcer
Issue Date1996
PublisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eid
Citation
Expert Opinion On Investigational Drugs, 1996, v. 5 n. 3, p. 345-353 How to Cite?
AbstractAntacids have been a very useful and effective class of drugs for the treatment of peptic ulcers for over a century, but have been overlooked in recent years. They are effective, safe and economical. In 13 randomised, controlled trials with endoscopic evidence of healing as the end-point, antacids heal 74% of duodenal ulcers in 4 weeks. The evidence for their efficacy in healing gastric ulcers is less strong. For maximal efficacy, adequate doses (e.g., an acid neutralising capacity > 400 mmol/day) need to be taken not intermittently but regularly, several times a day after meals. This regimen may lead to problems with compliance. Tablet forms are more convenient and are as effective as liquid forms. Liquid antacid is of proven value in the prophylaxis of stress ulcer bleeding. Certain antacids may be cytoprotective and more basic research is needed in this area. At the same time, the inclusion of antacids in therapeutic regimens for the healing and prevention of peptic ulcers, and for symptomatic relief during and after eradication of Helicobacter pylori should be explored. Due to their low production costs, antacids have a definite role in developing countries.
Persistent Identifierhttp://hdl.handle.net/10722/91629
ISSN
2015 Impact Factor: 4.408
2015 SCImago Journal Rankings: 1.314

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLam, SKen_HK
dc.date.accessioned2010-09-17T10:22:27Z-
dc.date.available2010-09-17T10:22:27Z-
dc.date.issued1996en_HK
dc.identifier.citationExpert Opinion On Investigational Drugs, 1996, v. 5 n. 3, p. 345-353en_HK
dc.identifier.issn1354-3784en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91629-
dc.description.abstractAntacids have been a very useful and effective class of drugs for the treatment of peptic ulcers for over a century, but have been overlooked in recent years. They are effective, safe and economical. In 13 randomised, controlled trials with endoscopic evidence of healing as the end-point, antacids heal 74% of duodenal ulcers in 4 weeks. The evidence for their efficacy in healing gastric ulcers is less strong. For maximal efficacy, adequate doses (e.g., an acid neutralising capacity > 400 mmol/day) need to be taken not intermittently but regularly, several times a day after meals. This regimen may lead to problems with compliance. Tablet forms are more convenient and are as effective as liquid forms. Liquid antacid is of proven value in the prophylaxis of stress ulcer bleeding. Certain antacids may be cytoprotective and more basic research is needed in this area. At the same time, the inclusion of antacids in therapeutic regimens for the healing and prevention of peptic ulcers, and for symptomatic relief during and after eradication of Helicobacter pylori should be explored. Due to their low production costs, antacids have a definite role in developing countries.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.expertopin.com/loi/eiden_HK
dc.relation.ispartofExpert Opinion on Investigational Drugsen_HK
dc.subjectAntacidsen_HK
dc.subjectDuodenal ulceren_HK
dc.subjectGastric ulceren_HK
dc.subjectPeptic ulceren_HK
dc.titleIs there a role for antacids in the modern management of peptic ulcers?en_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.scopuseid_2-s2.0-0029870262en_HK
dc.identifier.volume5en_HK
dc.identifier.issue3en_HK
dc.identifier.spage345en_HK
dc.identifier.epage353en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK

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