File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Association of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin gene

TitleAssociation of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin gene
Authors
Issue Date1998
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/
Citation
Arthritis And Rheumatism, 1998, v. 41 n. 9, p. 1663-1668 How to Cite?
AbstractObjective. To investigate the distribution of promoter variants of the mannose-binding lectin (MBL) gene and correlations between the promoter variants and serum MBL concentrations in Chinese patients with systemic lupus erythematosus (SLE) and in healthy Chinese controls. Methods. We studied the serum MBL levels and codon 54 mutation in 112 Chinese patients with SLE and 110 healthy controls. Genotyping of promoter variants of the MBL gene were done by polymerase chain reaction and allele-specific oligonucleotide hybridization. Results. We found significant differences in the distribution of the 2 pairs of promoter polymorphisms, H/L and Y/X, between SLE patients and controls (P = 0.018 and P = 0.019, respectively). Analysis of the correlation between promoter haplotypes and serum MBL levels revealed HY as the highest-producing, LY as the intermediate-producing, and LX as the lowest-producing haplotypes. The LX haplotype was present at a frequency of 0.259 in SLE patients and 0.154 in controls and was significantly associated with SLE (P = 0.019, odds ratio 1.79, 95% confidence interval 1.12-2.85). Conclusion. The low-producing promoter polymorphism of the MBL gene is associated with SLE, and a low serum MBL level is a risk factor for SLE. Even allowing for promoter polymorphisms and structural mutations of the MBL gene, serum MBL levels in SLE patients are still lower than those in controls, suggesting a trans-factor in regulating serum MBL levels.
Persistent Identifierhttp://hdl.handle.net/10722/91618
ISSN
2015 Impact Factor: 8.955
2015 SCImago Journal Rankings: 3.206
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorIp, WKen_HK
dc.contributor.authorChan, SYen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorLau, YLen_HK
dc.date.accessioned2010-09-17T10:22:17Z-
dc.date.available2010-09-17T10:22:17Z-
dc.date.issued1998en_HK
dc.identifier.citationArthritis And Rheumatism, 1998, v. 41 n. 9, p. 1663-1668en_HK
dc.identifier.issn0004-3591en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91618-
dc.description.abstractObjective. To investigate the distribution of promoter variants of the mannose-binding lectin (MBL) gene and correlations between the promoter variants and serum MBL concentrations in Chinese patients with systemic lupus erythematosus (SLE) and in healthy Chinese controls. Methods. We studied the serum MBL levels and codon 54 mutation in 112 Chinese patients with SLE and 110 healthy controls. Genotyping of promoter variants of the MBL gene were done by polymerase chain reaction and allele-specific oligonucleotide hybridization. Results. We found significant differences in the distribution of the 2 pairs of promoter polymorphisms, H/L and Y/X, between SLE patients and controls (P = 0.018 and P = 0.019, respectively). Analysis of the correlation between promoter haplotypes and serum MBL levels revealed HY as the highest-producing, LY as the intermediate-producing, and LX as the lowest-producing haplotypes. The LX haplotype was present at a frequency of 0.259 in SLE patients and 0.154 in controls and was significantly associated with SLE (P = 0.019, odds ratio 1.79, 95% confidence interval 1.12-2.85). Conclusion. The low-producing promoter polymorphism of the MBL gene is associated with SLE, and a low serum MBL level is a risk factor for SLE. Even allowing for promoter polymorphisms and structural mutations of the MBL gene, serum MBL levels in SLE patients are still lower than those in controls, suggesting a trans-factor in regulating serum MBL levels.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0004-3591/en_HK
dc.relation.ispartofArthritis and Rheumatismen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshCarrier Proteins - blood - geneticsen_HK
dc.subject.meshChilden_HK
dc.subject.meshCollectinsen_HK
dc.subject.meshDNA Primers - chemistryen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshHaplotypesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfant, Newbornen_HK
dc.subject.meshLupus Erythematosus, Systemic - blood - geneticsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPolymorphism, Geneticen_HK
dc.subject.meshPromoter Regions, Genetic - geneticsen_HK
dc.titleAssociation of systemic lupus erythematosus with promoter polymorphisms of the mannose-binding lectin geneen_HK
dc.typeArticleen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9751100-
dc.identifier.scopuseid_2-s2.0-0031682102en_HK
dc.identifier.hkuros39301-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031682102&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1663en_HK
dc.identifier.epage1668en_HK
dc.identifier.isiWOS:000076066400017-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridIp, WK=35083568800en_HK
dc.identifier.scopusauthoridChan, SY=7404255960en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats