Article: Queen Mary Utilization of Antihypertensive Drugs Study: Side-effects of antihypertensive drugs

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TitleQueen Mary Utilization of Antihypertensive Drugs Study: Side-effects of antihypertensive drugs
AuthorsCheung, BMY1 3
Wong, YL2 4
Lau, CP1
Issue Date2005
PublisherBlackwell Publishing Ltd
CitationJournal Of Clinical Pharmacy And Therapeutics, 2005, v. 30 n. 4, p. 391-399 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2710.2005.00662.x
AbstractBackground and objective: Effective prevention of cardiovascular events in hypertensive patients requires good control of blood pressure. Side-effects of antihypertensive drugs affect tolerability and compliance. Accordingly, we surveyed side-effects in the hypertension outpatient clinic. Methods: A total of 228 patients (109 men, 119 women) were interviewed in April-May 2004 in the Queen Mary Utilization of Antihypertensive Drugs Study. Results: The percentage of patients receiving no drug (life-style modification), one, two, three and over three drugs were 3, 30, 40, 22 and 6% respectively. The proportion of patients taking calcium channel blockers, β-blockers (BB), angiotensin-converting enzyme inhibitors, thiazide diuretics, α-blockers and angiotensin receptor blockers were 65, 64, 33, 24, 4 and 7% respectively. Blood pressure on treatment was 144 ± 21/ 82 ± 11 mmHg. Among patients on antihypertensive drug therapy, 34% reported adverse effects: dizziness (9%), ankle swelling (7%), headache (5%), fatigue (4%), chest discomfort (3%) and cough (3%). Fewer patients on BBs reported side-effects (OR 0.46, P = 0.008). The likelihood of experiencing side-effects was unrelated to sex, age, weight, BMI, years of treatment, number of drugs used, heart rate on treatment or compliance. Conclusions: To achieve good blood pressure control, multiple drugs are used. Thiazides are underused whereas BBs are popular. The popularity of the latter may be related to its tolerability. © 2005 Blackwell Publishing Ltd.
ISSN0269-4727
2011 Impact Factor: 1.57
2011 SCImago Journal Rankings: 0.099
DOIhttp://dx.doi.org/10.1111/j.1365-2710.2005.00662.x
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, BMY
dc.contributor.authorWong, YL
dc.contributor.authorLau, CP
dc.date.accessioned2010-09-17T10:22:11Z
dc.date.available2010-09-17T10:22:11Z
dc.date.issued2005
dc.description.abstractBackground and objective: Effective prevention of cardiovascular events in hypertensive patients requires good control of blood pressure. Side-effects of antihypertensive drugs affect tolerability and compliance. Accordingly, we surveyed side-effects in the hypertension outpatient clinic. Methods: A total of 228 patients (109 men, 119 women) were interviewed in April-May 2004 in the Queen Mary Utilization of Antihypertensive Drugs Study. Results: The percentage of patients receiving no drug (life-style modification), one, two, three and over three drugs were 3, 30, 40, 22 and 6% respectively. The proportion of patients taking calcium channel blockers, β-blockers (BB), angiotensin-converting enzyme inhibitors, thiazide diuretics, α-blockers and angiotensin receptor blockers were 65, 64, 33, 24, 4 and 7% respectively. Blood pressure on treatment was 144 ± 21/ 82 ± 11 mmHg. Among patients on antihypertensive drug therapy, 34% reported adverse effects: dizziness (9%), ankle swelling (7%), headache (5%), fatigue (4%), chest discomfort (3%) and cough (3%). Fewer patients on BBs reported side-effects (OR 0.46, P = 0.008). The likelihood of experiencing side-effects was unrelated to sex, age, weight, BMI, years of treatment, number of drugs used, heart rate on treatment or compliance. Conclusions: To achieve good blood pressure control, multiple drugs are used. Thiazides are underused whereas BBs are popular. The popularity of the latter may be related to its tolerability. © 2005 Blackwell Publishing Ltd.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationJournal Of Clinical Pharmacy And Therapeutics, 2005, v. 30 n. 4, p. 391-399 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1365-2710.2005.00662.x
dc.identifier.citeulike243508
dc.identifier.doihttp://dx.doi.org/10.1111/j.1365-2710.2005.00662.x
dc.identifier.eissn1365-2710
dc.identifier.epage399
dc.identifier.hkuros180181
dc.identifier.isiWOS:000230142900011
dc.identifier.issn0269-4727
2011 Impact Factor: 1.57
2011 SCImago Journal Rankings: 0.099
dc.identifier.issue4
dc.identifier.pmid15985053
dc.identifier.scopuseid_2-s2.0-26944480136
dc.identifier.spage391
dc.identifier.urihttp://hdl.handle.net/10722/91612
dc.identifier.volume30
dc.languageeng
dc.publisherBlackwell Publishing Ltd
dc.publisher.placeUnited Kingdom
dc.relation.ispartofJournal of Clinical Pharmacy and Therapeutics
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshAntihypertensive Agents - adverse effects - therapeutic use
dc.subject.meshBlood Pressure - drug effects
dc.subject.meshFemale
dc.subject.meshHealth Care Surveys
dc.subject.meshHumans
dc.subject.meshHypertension - drug therapy
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPatient Compliance
dc.titleQueen Mary Utilization of Antihypertensive Drugs Study: Side-effects of antihypertensive drugs
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. University of Sunderland
  3. Queen Mary Hospital Hong Kong
  4. University of Hong Kong, School of Professional and Continuing Education