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Article: Queen Mary Utilization of Antihypertensive Drugs Study: Side-effects of antihypertensive drugs

TitleQueen Mary Utilization of Antihypertensive Drugs Study: Side-effects of antihypertensive drugs
Authors
Issue Date2005
PublisherBlackwell Publishing Ltd
Citation
Journal Of Clinical Pharmacy And Therapeutics, 2005, v. 30 n. 4, p. 391-399 How to Cite?
AbstractBackground and objective: Effective prevention of cardiovascular events in hypertensive patients requires good control of blood pressure. Side-effects of antihypertensive drugs affect tolerability and compliance. Accordingly, we surveyed side-effects in the hypertension outpatient clinic. Methods: A total of 228 patients (109 men, 119 women) were interviewed in April-May 2004 in the Queen Mary Utilization of Antihypertensive Drugs Study. Results: The percentage of patients receiving no drug (life-style modification), one, two, three and over three drugs were 3, 30, 40, 22 and 6% respectively. The proportion of patients taking calcium channel blockers, β-blockers (BB), angiotensin-converting enzyme inhibitors, thiazide diuretics, α-blockers and angiotensin receptor blockers were 65, 64, 33, 24, 4 and 7% respectively. Blood pressure on treatment was 144 ± 21/ 82 ± 11 mmHg. Among patients on antihypertensive drug therapy, 34% reported adverse effects: dizziness (9%), ankle swelling (7%), headache (5%), fatigue (4%), chest discomfort (3%) and cough (3%). Fewer patients on BBs reported side-effects (OR 0.46, P = 0.008). The likelihood of experiencing side-effects was unrelated to sex, age, weight, BMI, years of treatment, number of drugs used, heart rate on treatment or compliance. Conclusions: To achieve good blood pressure control, multiple drugs are used. Thiazides are underused whereas BBs are popular. The popularity of the latter may be related to its tolerability. © 2005 Blackwell Publishing Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/91612
ISSN
2014 Impact Factor: 1.668
2014 SCImago Journal Rankings: 0.609
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorWong, YLen_HK
dc.contributor.authorLau, CPen_HK
dc.date.accessioned2010-09-17T10:22:11Z-
dc.date.available2010-09-17T10:22:11Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of Clinical Pharmacy And Therapeutics, 2005, v. 30 n. 4, p. 391-399en_HK
dc.identifier.issn0269-4727en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91612-
dc.description.abstractBackground and objective: Effective prevention of cardiovascular events in hypertensive patients requires good control of blood pressure. Side-effects of antihypertensive drugs affect tolerability and compliance. Accordingly, we surveyed side-effects in the hypertension outpatient clinic. Methods: A total of 228 patients (109 men, 119 women) were interviewed in April-May 2004 in the Queen Mary Utilization of Antihypertensive Drugs Study. Results: The percentage of patients receiving no drug (life-style modification), one, two, three and over three drugs were 3, 30, 40, 22 and 6% respectively. The proportion of patients taking calcium channel blockers, β-blockers (BB), angiotensin-converting enzyme inhibitors, thiazide diuretics, α-blockers and angiotensin receptor blockers were 65, 64, 33, 24, 4 and 7% respectively. Blood pressure on treatment was 144 ± 21/ 82 ± 11 mmHg. Among patients on antihypertensive drug therapy, 34% reported adverse effects: dizziness (9%), ankle swelling (7%), headache (5%), fatigue (4%), chest discomfort (3%) and cough (3%). Fewer patients on BBs reported side-effects (OR 0.46, P = 0.008). The likelihood of experiencing side-effects was unrelated to sex, age, weight, BMI, years of treatment, number of drugs used, heart rate on treatment or compliance. Conclusions: To achieve good blood pressure control, multiple drugs are used. Thiazides are underused whereas BBs are popular. The popularity of the latter may be related to its tolerability. © 2005 Blackwell Publishing Ltd.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltden_HK
dc.relation.ispartofJournal of Clinical Pharmacy and Therapeuticsen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntihypertensive Agents - adverse effects - therapeutic useen_HK
dc.subject.meshBlood Pressure - drug effectsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHealth Care Surveysen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - drug therapyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPatient Complianceen_HK
dc.titleQueen Mary Utilization of Antihypertensive Drugs Study: Side-effects of antihypertensive drugsen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2710.2005.00662.xen_HK
dc.identifier.pmid15985053-
dc.identifier.scopuseid_2-s2.0-26944480136en_HK
dc.identifier.hkuros180181-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-26944480136&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume30en_HK
dc.identifier.issue4en_HK
dc.identifier.spage391en_HK
dc.identifier.epage399en_HK
dc.identifier.eissn1365-2710-
dc.identifier.isiWOS:000230142900011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridWong, YL=7403040297en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.citeulike243508-

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