Article: Polymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese

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TitlePolymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese
AuthorsWong, LYF1
Ong, KL1
Cheung, BMY1 3
Leung, RYH1
Man, YB4
Lam, TH1 2
KeywordsFibrinogen
Haplotype
Impaired glucose tolerance
Polymorphism
Issue Date2008
PublisherI O S Press. The Journal's web site is located at http://www.iospress.nl/html/02780240.php
CitationDisease Markers, 2008, v. 24 n. 3, p. 167-173 [How to Cite?]
AbstractFibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-β gene (FGB) variants, -455G>A, -249C>T, and -148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 ± 0.65 vs 2.42 ± 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 ± 1.14 vs 5.47 ± 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance. © 2008 - IOS Press and the authors. All rights reserved.
ISSN0278-0240
2011 Impact Factor: 1.642
2011 SCImago Journal Rankings: 0.196
ISI Accession Number IDWOS:000254578600005
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWong, LYF
dc.contributor.authorOng, KL
dc.contributor.authorCheung, BMY
dc.contributor.authorLeung, RYH
dc.contributor.authorMan, YB
dc.contributor.authorLam, TH
dc.date.accessioned2010-09-17T10:21:56Z
dc.date.available2010-09-17T10:21:56Z
dc.date.issued2008
dc.description.abstractFibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-β gene (FGB) variants, -455G>A, -249C>T, and -148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 ± 0.65 vs 2.42 ± 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 ± 1.14 vs 5.47 ± 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance. © 2008 - IOS Press and the authors. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationDisease Markers, 2008, v. 24 n. 3, p. 167-173 [How to Cite?]
dc.identifier.epage173
dc.identifier.hkuros180101
dc.identifier.isiWOS:000254578600005
dc.identifier.issn0278-0240
2011 Impact Factor: 1.642
2011 SCImago Journal Rankings: 0.196
dc.identifier.issue3
dc.identifier.pmid18334738
dc.identifier.scopuseid_2-s2.0-44449149913
dc.identifier.spage167
dc.identifier.urihttp://hdl.handle.net/10722/91596
dc.identifier.volume24
dc.languageeng
dc.publisherI O S Press. The Journal's web site is located at http://www.iospress.nl/html/02780240.php
dc.publisher.placeNetherlands
dc.relation.ispartofDisease Markers
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshBlood Glucose - analysis
dc.subject.meshFemale
dc.subject.meshFibrinogen - genetics
dc.subject.meshGenotype
dc.subject.meshGlucose Tolerance Test
dc.subject.meshHong Kong
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshRegression Analysis
dc.subjectFibrinogen
dc.subjectHaplotype
dc.subjectImpaired glucose tolerance
dc.subjectPolymorphism
dc.titlePolymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee
  3. University of Birmingham
  4. Chinese University of Hong Kong