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Article: Polymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese

TitlePolymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese
Authors
KeywordsFibrinogen
Haplotype
Impaired glucose tolerance
Polymorphism
Issue Date2008
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/02780240.php
Citation
Disease Markers, 2008, v. 24 n. 3, p. 167-173 How to Cite?
AbstractFibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-β gene (FGB) variants, -455G>A, -249C>T, and -148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 ± 0.65 vs 2.42 ± 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 ± 1.14 vs 5.47 ± 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance. © 2008 - IOS Press and the authors. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/91596
ISSN
2014 Impact Factor: 1.562
2013 SCImago Journal Rankings: 0.922
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, LYFen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorLeung, RYHen_HK
dc.contributor.authorMan, YBen_HK
dc.contributor.authorLam, THen_HK
dc.date.accessioned2010-09-17T10:21:56Z-
dc.date.available2010-09-17T10:21:56Z-
dc.date.issued2008en_HK
dc.identifier.citationDisease Markers, 2008, v. 24 n. 3, p. 167-173en_HK
dc.identifier.issn0278-0240en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91596-
dc.description.abstractFibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-β gene (FGB) variants, -455G>A, -249C>T, and -148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 ± 0.65 vs 2.42 ± 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 ± 1.14 vs 5.47 ± 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance. © 2008 - IOS Press and the authors. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/02780240.phpen_HK
dc.relation.ispartofDisease Markersen_HK
dc.subjectFibrinogenen_HK
dc.subjectHaplotypeen_HK
dc.subjectImpaired glucose toleranceen_HK
dc.subjectPolymorphismen_HK
dc.subject.meshAdulten_HK
dc.subject.meshBlood Glucose - analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFibrinogen - geneticsen_HK
dc.subject.meshGenotypeen_HK
dc.subject.meshGlucose Tolerance Testen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshRegression Analysisen_HK
dc.titlePolymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid18334738en_HK
dc.identifier.pmcidPMC3850617-
dc.identifier.scopuseid_2-s2.0-44449149913en_HK
dc.identifier.hkuros180101-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44449149913&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue3en_HK
dc.identifier.spage167en_HK
dc.identifier.epage173en_HK
dc.identifier.isiWOS:000254578600005-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridWong, LYF=24476809800en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridLeung, RYH=7101876102en_HK
dc.identifier.scopusauthoridMan, YB=10245005900en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK

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