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Article: Polymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese
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TitlePolymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese
 
AuthorsWong, LYF1
Ong, KL1
Cheung, BMY1 3
Leung, RYH1
Man, YB4
Lam, TH1 2
 
KeywordsFibrinogen
Haplotype
Impaired glucose tolerance
Polymorphism
 
Issue Date2008
 
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/02780240.php
 
CitationDisease Markers, 2008, v. 24 n. 3, p. 167-173 [How to Cite?]
 
AbstractFibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-β gene (FGB) variants, -455G>A, -249C>T, and -148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 ± 0.65 vs 2.42 ± 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 ± 1.14 vs 5.47 ± 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance. © 2008 - IOS Press and the authors. All rights reserved.
 
ISSN0278-0240
2013 Impact Factor: 2.174
2013 SCImago Journal Rankings: 0.922
 
PubMed Central IDPMC3850617
 
ISI Accession Number IDWOS:000254578600005
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, LYF
 
dc.contributor.authorOng, KL
 
dc.contributor.authorCheung, BMY
 
dc.contributor.authorLeung, RYH
 
dc.contributor.authorMan, YB
 
dc.contributor.authorLam, TH
 
dc.date.accessioned2010-09-17T10:21:56Z
 
dc.date.available2010-09-17T10:21:56Z
 
dc.date.issued2008
 
dc.description.abstractFibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-β gene (FGB) variants, -455G>A, -249C>T, and -148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G>A and -148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p<0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 ± 0.65 vs 2.42 ± 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 ± 1.14 vs 5.47 ± 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance. © 2008 - IOS Press and the authors. All rights reserved.
 
dc.description.natureLink_to_OA_fulltext
 
dc.identifier.citationDisease Markers, 2008, v. 24 n. 3, p. 167-173 [How to Cite?]
 
dc.identifier.epage173
 
dc.identifier.hkuros180101
 
dc.identifier.isiWOS:000254578600005
 
dc.identifier.issn0278-0240
2013 Impact Factor: 2.174
2013 SCImago Journal Rankings: 0.922
 
dc.identifier.issue3
 
dc.identifier.pmcidPMC3850617
 
dc.identifier.pmid18334738
 
dc.identifier.scopuseid_2-s2.0-44449149913
 
dc.identifier.spage167
 
dc.identifier.urihttp://hdl.handle.net/10722/91596
 
dc.identifier.volume24
 
dc.languageeng
 
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/02780240.php
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofDisease Markers
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshBlood Glucose - analysis
 
dc.subject.meshFemale
 
dc.subject.meshFibrinogen - genetics
 
dc.subject.meshGenotype
 
dc.subject.meshGlucose Tolerance Test
 
dc.subject.meshHong Kong
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPolymorphism, Single Nucleotide
 
dc.subject.meshRegression Analysis
 
dc.subjectFibrinogen
 
dc.subjectHaplotype
 
dc.subjectImpaired glucose tolerance
 
dc.subjectPolymorphism
 
dc.titlePolymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese
 
dc.typeArticle
 
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<item><contributor.author>Wong, LYF</contributor.author>
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<contributor.author>Man, YB</contributor.author>
<contributor.author>Lam, TH</contributor.author>
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<description.abstract>Fibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-&#946; gene (FGB) variants, -455G&gt;A, -249C&gt;T, and -148C&gt;T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, -455G&gt;A and -148C&gt;T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p&lt;0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions -455 and -249, had higher fibrinogen level (2.64 &#177; 0.65 vs 2.42 &#177; 0.52 g/L, p=0.002) and 2-h glucose after a 75-g oral glucose load (5.87 &#177; 1.14 vs 5.47 &#177; 1.22 g/L, p=0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p=0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance. &#169; 2008 - IOS Press and the authors. All rights reserved.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee
  3. University of Birmingham
  4. Chinese University of Hong Kong