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Article: Using the deadly μ-conotoxins as probes of voltage-gated sodium channels

TitleUsing the deadly μ-conotoxins as probes of voltage-gated sodium channels
Authors
Li, RATomaselli, GF
Keywordsμ-Conotoxin
Na channel
Pore
Issue Date2004
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/toxicon
Citation
Toxicon, 2004, v. 44 n. 2, p. 117-122 How to Cite?
DOI: http://dx.doi.org/10.1016/j.toxicon.2004.03.028
Abstractμ-Conotoxins (μ-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. μ-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Nav) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of μ-CTX and the associated structural and functional insights into its molecular target - Nav channels. © 2004 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/91561
ISSN
0041-0101
2023 Impact Factor: 2.6
2023 SCImago Journal Rankings: 0.516
PubMed Central ID
PMC2698010
ISI Accession Number ID
WOS:000223022000001
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLi, RAen_HK
dc.contributor.authorTomaselli, GFen_HK
dc.date.accessioned2010-09-17T10:21:23Z-
dc.date.available2010-09-17T10:21:23Z-
dc.date.issued2004en_HK
dc.identifier.citationToxicon, 2004, v. 44 n. 2, p. 117-122en_HK
dc.identifier.issn0041-0101en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91561-
dc.description.abstractμ-Conotoxins (μ-CTX) are potent Na channel inhibitory peptides isolated from the venom of the predatory marine snail Conus geographus. μ-CTXs exert their biological action by physically occluding the ion-conducting pore of voltage-gated Na (Nav) channels with a 1:1 stoichiometry in an all-or-none fashion. This article reviews our current knowledge of the mechanism of μ-CTX and the associated structural and functional insights into its molecular target - Nav channels. © 2004 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/toxiconen_HK
dc.relation.ispartofToxiconen_HK
dc.subjectμ-Conotoxinen_HK
dc.subjectNa channelen_HK
dc.subjectPoreen_HK
dc.titleUsing the deadly μ-conotoxins as probes of voltage-gated sodium channelsen_HK
dc.typeArticleen_HK
dc.identifier.emailLi, RA:ronaldli@hkucc.hku.hken_HK
dc.identifier.authorityLi, RA=rp01352en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.toxicon.2004.03.028en_HK
dc.identifier.pmid15246758-
dc.identifier.pmcidPMC2698010-
dc.identifier.scopuseid_2-s2.0-3042792925en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3042792925&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume44en_HK
dc.identifier.issue2en_HK
dc.identifier.spage117en_HK
dc.identifier.epage122en_HK
dc.identifier.isiWOS:000223022000001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, RA=7404724466en_HK
dc.identifier.scopusauthoridTomaselli, GF=7005223451en_HK
dc.identifier.issnl0041-0101-

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