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Article: Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004

TitleElevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal Of Cardiology, 2009, v. 135 n. 2, p. 156-161 How to Cite?
AbstractBackground: Alkaline phosphatase (ALP) is elevated in peripheral arterial disease (PAD). We therefore examined the relationship of PAD with ALP and other liver enzymes in the United States National Health and Nutrition Examination Survey 1999-2004. Methods: The analysis included 5995 men and non-pregnant women aged ≥ 40 years with no missing data in variables of interest. PAD was defined as ankle-brachial blood pressure index (ABI) < 0.90 in either leg. Results: Serum alkaline phosphatase (ALP) level was associated significantly with lower ABI after adjustment for confounding factors ( p = 0.019). No significant association of ABI with other liver enzymes was found. Serum ALP level increased with increasing age, body mass index, C-reactive protein, monocyte count, serum uric acid, lead, cadmium, and prevalence of hypercholesterolemia, diabetes, smoking, non-alcohol drinking, and cardiovascular diseases after adjusting for age, sex, race/ethnicity, and survey years (p < 0.02). The highest quartile of serum ALP was associated with an odds ratio of 1.89 (95% confidence interval [CI]: 1.25-2.85) for PAD after adjustment for confounding factors (p for trend = 0.023). In subjects with normal kidney function (glomerular filtration rate > 90 ml/min/1.73 m2), the odds ratio increased to 4.22 (95% CI 1.45-12.35) (p = 0.010). Conclusion: Elevated serum ALP is correlated with PAD, independent of other traditional cardiovascular risk factors. © 2008 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/91554
ISSN
2014 Impact Factor: 4.036
2014 SCImago Journal Rankings: 1.151
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorWong, LYFen_HK
dc.date.accessioned2010-09-17T10:21:16Z-
dc.date.available2010-09-17T10:21:16Z-
dc.date.issued2009en_HK
dc.identifier.citationInternational Journal Of Cardiology, 2009, v. 135 n. 2, p. 156-161en_HK
dc.identifier.issn0167-5273en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91554-
dc.description.abstractBackground: Alkaline phosphatase (ALP) is elevated in peripheral arterial disease (PAD). We therefore examined the relationship of PAD with ALP and other liver enzymes in the United States National Health and Nutrition Examination Survey 1999-2004. Methods: The analysis included 5995 men and non-pregnant women aged ≥ 40 years with no missing data in variables of interest. PAD was defined as ankle-brachial blood pressure index (ABI) < 0.90 in either leg. Results: Serum alkaline phosphatase (ALP) level was associated significantly with lower ABI after adjustment for confounding factors ( p = 0.019). No significant association of ABI with other liver enzymes was found. Serum ALP level increased with increasing age, body mass index, C-reactive protein, monocyte count, serum uric acid, lead, cadmium, and prevalence of hypercholesterolemia, diabetes, smoking, non-alcohol drinking, and cardiovascular diseases after adjusting for age, sex, race/ethnicity, and survey years (p < 0.02). The highest quartile of serum ALP was associated with an odds ratio of 1.89 (95% confidence interval [CI]: 1.25-2.85) for PAD after adjustment for confounding factors (p for trend = 0.023). In subjects with normal kidney function (glomerular filtration rate > 90 ml/min/1.73 m2), the odds ratio increased to 4.22 (95% CI 1.45-12.35) (p = 0.010). Conclusion: Elevated serum ALP is correlated with PAD, independent of other traditional cardiovascular risk factors. © 2008 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_HK
dc.relation.ispartofInternational Journal of Cardiologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Distributionen_HK
dc.subject.meshAlcohol Drinking - epidemiologyen_HK
dc.subject.meshAlkaline Phosphatase - blooden_HK
dc.subject.meshBody Mass Indexen_HK
dc.subject.meshDiabetes Mellitus - epidemiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlomerular Filtration Rateen_HK
dc.subject.meshHealth Surveysen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypercholesterolemia - epidemiologyen_HK
dc.subject.meshLiver - enzymologyen_HK
dc.subject.meshLogistic Modelsen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPeripheral Vascular Diseases - blood - epidemiologyen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshUnited States - epidemiologyen_HK
dc.titleElevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004en_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijcard.2008.03.039en_HK
dc.identifier.pmid18572267en_HK
dc.identifier.scopuseid_2-s2.0-67349112786en_HK
dc.identifier.hkuros180003-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349112786&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume135en_HK
dc.identifier.issue2en_HK
dc.identifier.spage156en_HK
dc.identifier.epage161en_HK
dc.identifier.isiWOS:000266884600004-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridWong, LYF=24476809800en_HK

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