Article: Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004

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TitleElevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004
AuthorsCheung, BMY1
Ong, KL1
Wong, LYF1
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
CitationInternational Journal Of Cardiology, 2009, v. 135 n. 2, p. 156-161 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2008.03.039
AbstractBackground: Alkaline phosphatase (ALP) is elevated in peripheral arterial disease (PAD). We therefore examined the relationship of PAD with ALP and other liver enzymes in the United States National Health and Nutrition Examination Survey 1999-2004. Methods: The analysis included 5995 men and non-pregnant women aged ≥ 40 years with no missing data in variables of interest. PAD was defined as ankle-brachial blood pressure index (ABI) < 0.90 in either leg. Results: Serum alkaline phosphatase (ALP) level was associated significantly with lower ABI after adjustment for confounding factors ( p = 0.019). No significant association of ABI with other liver enzymes was found. Serum ALP level increased with increasing age, body mass index, C-reactive protein, monocyte count, serum uric acid, lead, cadmium, and prevalence of hypercholesterolemia, diabetes, smoking, non-alcohol drinking, and cardiovascular diseases after adjusting for age, sex, race/ethnicity, and survey years (p < 0.02). The highest quartile of serum ALP was associated with an odds ratio of 1.89 (95% confidence interval [CI]: 1.25-2.85) for PAD after adjustment for confounding factors (p for trend = 0.023). In subjects with normal kidney function (glomerular filtration rate > 90 ml/min/1.73 m2), the odds ratio increased to 4.22 (95% CI 1.45-12.35) (p = 0.010). Conclusion: Elevated serum ALP is correlated with PAD, independent of other traditional cardiovascular risk factors. © 2008 Elsevier Ireland Ltd. All rights reserved.
ISSN0167-5273
2011 Impact Factor: 7.078
2011 SCImago Journal Rankings: 0.144
DOIhttp://dx.doi.org/10.1016/j.ijcard.2008.03.039
ISI Accession Number IDWOS:000266884600004
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, BMY
dc.contributor.authorOng, KL
dc.contributor.authorWong, LYF
dc.date.accessioned2010-09-17T10:21:16Z
dc.date.available2010-09-17T10:21:16Z
dc.date.issued2009
dc.description.abstractBackground: Alkaline phosphatase (ALP) is elevated in peripheral arterial disease (PAD). We therefore examined the relationship of PAD with ALP and other liver enzymes in the United States National Health and Nutrition Examination Survey 1999-2004. Methods: The analysis included 5995 men and non-pregnant women aged ≥ 40 years with no missing data in variables of interest. PAD was defined as ankle-brachial blood pressure index (ABI) < 0.90 in either leg. Results: Serum alkaline phosphatase (ALP) level was associated significantly with lower ABI after adjustment for confounding factors ( p = 0.019). No significant association of ABI with other liver enzymes was found. Serum ALP level increased with increasing age, body mass index, C-reactive protein, monocyte count, serum uric acid, lead, cadmium, and prevalence of hypercholesterolemia, diabetes, smoking, non-alcohol drinking, and cardiovascular diseases after adjusting for age, sex, race/ethnicity, and survey years (p < 0.02). The highest quartile of serum ALP was associated with an odds ratio of 1.89 (95% confidence interval [CI]: 1.25-2.85) for PAD after adjustment for confounding factors (p for trend = 0.023). In subjects with normal kidney function (glomerular filtration rate > 90 ml/min/1.73 m2), the odds ratio increased to 4.22 (95% CI 1.45-12.35) (p = 0.010). Conclusion: Elevated serum ALP is correlated with PAD, independent of other traditional cardiovascular risk factors. © 2008 Elsevier Ireland Ltd. All rights reserved.
dc.description.naturelink_to_subscribed_fulltext
dc.identifier.citationInternational Journal Of Cardiology, 2009, v. 135 n. 2, p. 156-161 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2008.03.039
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijcard.2008.03.039
dc.identifier.epage161
dc.identifier.hkuros180003
dc.identifier.isiWOS:000266884600004
dc.identifier.issn0167-5273
2011 Impact Factor: 7.078
2011 SCImago Journal Rankings: 0.144
dc.identifier.issue2
dc.identifier.pmid18572267
dc.identifier.scopuseid_2-s2.0-67349112786
dc.identifier.spage156
dc.identifier.urihttp://hdl.handle.net/10722/91554
dc.identifier.volume135
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
dc.publisher.placeIreland
dc.relation.ispartofInternational Journal of Cardiology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAge Distribution
dc.subject.meshAlcohol Drinking - epidemiology
dc.subject.meshAlkaline Phosphatase - blood
dc.subject.meshBody Mass Index
dc.subject.meshDiabetes Mellitus - epidemiology
dc.subject.meshFemale
dc.subject.meshGlomerular Filtration Rate
dc.subject.meshHealth Surveys
dc.subject.meshHumans
dc.subject.meshHypercholesterolemia - epidemiology
dc.subject.meshLiver - enzymology
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPeripheral Vascular Diseases - blood - epidemiology
dc.subject.meshPrevalence
dc.subject.meshRisk Factors
dc.subject.meshUnited States - epidemiology
dc.subjectChemicals And Cas Registry Numbers
dc.titleElevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong