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Article: Prolonged seated immobility-associated venous coagulability in a factor V Leiden heterozygote: A case-comparative study

TitleProlonged seated immobility-associated venous coagulability in a factor V Leiden heterozygote: A case-comparative study
Authors
KeywordsChemicals And Cas Registry Numbers
Blood coagulation
Factor V
Immobilization
Posture
Venous thrombosis
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.bloodcoagulation.com
Citation
Blood Coagulation And Fibrinolysis, 2006, v. 17 n. 3, p. 187-191 How to Cite?
AbstractProlonged sitting and thrombophilia may compound the risk of venous thromboembolism. In order to investigate suspected local lower limb venous procoagulant changes associated with prolonged sitting-induced venous stasis in a man heterozygous for factor V Leiden (participant X), we qualitatively compared venous coagulability in lower and upper limb plasma in this participant and three other male Caucasians over 8 h of sitting. Of the four participants, participant X had the highest baseline values of prothrombin fragments 1 and 2, thrombin-antithrombin III complexes, tissue plasminogen activator, plasminogen activator inhibitor 1, D-dimer and soluble thrombomodulin. Over time, in participant X, venous prothrombin fragments 1 and 2, thrombin-antithrombin III complexes, and soluble thrombomodulin decreased in both limbs; D-dimer decreased in the lower limbs but increased in the upper limbs; the tissue plasminogen activator/plasminogen activator inhibitor 1 molar ratio increased in both limbs; and minimal changes were noted in haematocrit. A foot volume increase was associated with vague symptoms towards the end of the study. Overall, these changes were similar to those observed in other participants. It is concluded from this case comparison that prolonged sitting of 8 h duration under normal atmospheric conditions did not result in local, as well as systemic, procoagulant haemostatic responses in a heterozygote for factor V Leiden when compared with other healthy volunteers. However, this observed, possibly adaptive, response is more likely to be compromised in factor V Leiden subjects during continued or increased venous endothelial stress or in the presence of other venous thromboembolism risk factors. © 2006 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/91549
ISSN
2015 Impact Factor: 1.242
2015 SCImago Journal Rankings: 0.496
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAnsari, MTen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorKarlberg, JPEen_HK
dc.date.accessioned2010-09-17T10:21:11Z-
dc.date.available2010-09-17T10:21:11Z-
dc.date.issued2006en_HK
dc.identifier.citationBlood Coagulation And Fibrinolysis, 2006, v. 17 n. 3, p. 187-191en_HK
dc.identifier.issn0957-5235en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91549-
dc.description.abstractProlonged sitting and thrombophilia may compound the risk of venous thromboembolism. In order to investigate suspected local lower limb venous procoagulant changes associated with prolonged sitting-induced venous stasis in a man heterozygous for factor V Leiden (participant X), we qualitatively compared venous coagulability in lower and upper limb plasma in this participant and three other male Caucasians over 8 h of sitting. Of the four participants, participant X had the highest baseline values of prothrombin fragments 1 and 2, thrombin-antithrombin III complexes, tissue plasminogen activator, plasminogen activator inhibitor 1, D-dimer and soluble thrombomodulin. Over time, in participant X, venous prothrombin fragments 1 and 2, thrombin-antithrombin III complexes, and soluble thrombomodulin decreased in both limbs; D-dimer decreased in the lower limbs but increased in the upper limbs; the tissue plasminogen activator/plasminogen activator inhibitor 1 molar ratio increased in both limbs; and minimal changes were noted in haematocrit. A foot volume increase was associated with vague symptoms towards the end of the study. Overall, these changes were similar to those observed in other participants. It is concluded from this case comparison that prolonged sitting of 8 h duration under normal atmospheric conditions did not result in local, as well as systemic, procoagulant haemostatic responses in a heterozygote for factor V Leiden when compared with other healthy volunteers. However, this observed, possibly adaptive, response is more likely to be compromised in factor V Leiden subjects during continued or increased venous endothelial stress or in the presence of other venous thromboembolism risk factors. © 2006 Lippincott Williams & Wilkins.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.bloodcoagulation.comen_HK
dc.relation.ispartofBlood Coagulation and Fibrinolysisen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subjectBlood coagulation-
dc.subjectFactor V-
dc.subjectImmobilization-
dc.subjectPosture-
dc.subjectVenous thrombosis-
dc.subject.meshAdulten_HK
dc.subject.meshFactor V - genetics - metabolismen_HK
dc.subject.meshHeterozygoteen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmobilization - physiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPoint Mutation - geneticsen_HK
dc.subject.meshPosture - physiologyen_HK
dc.subject.meshReference Valuesen_HK
dc.subject.meshVenous Thrombosis - geneticsen_HK
dc.titleProlonged seated immobility-associated venous coagulability in a factor V Leiden heterozygote: A case-comparative studyen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailKarlberg, JPE:jpekarl@hkucc.hku.hken_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityKarlberg, JPE=rp00400en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.mbc.0000220240.45585.5een_HK
dc.identifier.pmid16575256-
dc.identifier.scopuseid_2-s2.0-33645503735en_HK
dc.identifier.hkuros115269-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645503735&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue3en_HK
dc.identifier.spage187en_HK
dc.identifier.epage191en_HK
dc.identifier.isiWOS:000237543500004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAnsari, MT=8630124500en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridKarlberg, JPE=7005218406en_HK

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