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Article: Autoantibody formation after allogeneic bone marrow transplantation: Correlation with the reconstitution of CD5+ B cells and occurrence of graft-versus-host disease

TitleAutoantibody formation after allogeneic bone marrow transplantation: Correlation with the reconstitution of CD5+ B cells and occurrence of graft-versus-host disease
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1997
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.asp
Citation
Pathology, 1997, v. 29 n. 2, p. 184-188 How to Cite?
AbstractManifestations of autoimmune diseases are common in patients who have received allogeneic bone marrow transplantation (BMT). Autoantibodies have been reported in these patients but the source and clinical significance of these autoantibodies are still obscure. In the present study the kinetics of autoantibody formation and the reconstitution of CD5 + B cells was followed in 21 patients who were submitted to allogeneic BMT. Anti-nuclear, anti-smooth muscle, anti-neutrophil cytoplasmic antibodies, anti-reticulin and rheumatoid factor were found at a frequency of 25%, 17%, 24%, 22% and 10% respectively after BMT. Anti-double stranded DNA levels were mildly elevated in 15% of samples. The screening for anti-extractable nuclear antigen, anti-mitochondrial, anti-gastric parietal cell, anti-proteinase III, anti-myeloperoxidase, anti-lactoferrin antibodies was negative. The percentage and absolute count of CD5 + B cells increased with time after allogeneic BMT. Those patients with anti-nuclear or anti-smooth muscle antibodies had significantly higher CD5 + B cell counts than those without these two antibodies. Correlations of CD5 + B cell counts with other autoantibodies were negative. Acute graft-versus-host disease (GVHD) occurred in eight of the patients and chronic GVHD in four patients, but the frequency of autoantibodies had no relationship with the occurrence of acute or chronic GVHD.
Persistent Identifierhttp://hdl.handle.net/10722/91522
ISSN
2015 Impact Factor: 2.968
2015 SCImago Journal Rankings: 1.049
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, EYTen_HK
dc.contributor.authorLawton, JWMen_HK
dc.contributor.authorLie, AKWen_HK
dc.contributor.authorLau, CSen_HK
dc.date.accessioned2010-09-17T10:20:45Z-
dc.date.available2010-09-17T10:20:45Z-
dc.date.issued1997en_HK
dc.identifier.citationPathology, 1997, v. 29 n. 2, p. 184-188en_HK
dc.identifier.issn0031-3025en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91522-
dc.description.abstractManifestations of autoimmune diseases are common in patients who have received allogeneic bone marrow transplantation (BMT). Autoantibodies have been reported in these patients but the source and clinical significance of these autoantibodies are still obscure. In the present study the kinetics of autoantibody formation and the reconstitution of CD5 + B cells was followed in 21 patients who were submitted to allogeneic BMT. Anti-nuclear, anti-smooth muscle, anti-neutrophil cytoplasmic antibodies, anti-reticulin and rheumatoid factor were found at a frequency of 25%, 17%, 24%, 22% and 10% respectively after BMT. Anti-double stranded DNA levels were mildly elevated in 15% of samples. The screening for anti-extractable nuclear antigen, anti-mitochondrial, anti-gastric parietal cell, anti-proteinase III, anti-myeloperoxidase, anti-lactoferrin antibodies was negative. The percentage and absolute count of CD5 + B cells increased with time after allogeneic BMT. Those patients with anti-nuclear or anti-smooth muscle antibodies had significantly higher CD5 + B cell counts than those without these two antibodies. Correlations of CD5 + B cell counts with other autoantibodies were negative. Acute graft-versus-host disease (GVHD) occurred in eight of the patients and chronic GVHD in four patients, but the frequency of autoantibodies had no relationship with the occurrence of acute or chronic GVHD.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.aspen_HK
dc.relation.ispartofPathologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAntigens, CD5 - metabolismen_HK
dc.subject.meshAutoantibodies - metabolismen_HK
dc.subject.meshB-Lymphocytes - immunologyen_HK
dc.subject.meshBone Marrow Transplantation - adverse effectsen_HK
dc.subject.meshGraft vs Host Disease - immunologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshTime Factorsen_HK
dc.titleAutoantibody formation after allogeneic bone marrow transplantation: Correlation with the reconstitution of CD5+ B cells and occurrence of graft-versus-host diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/00313029700169834en_HK
dc.identifier.pmid9213339-
dc.identifier.scopuseid_2-s2.0-0030805801en_HK
dc.identifier.hkuros38151-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030805801&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue2en_HK
dc.identifier.spage184en_HK
dc.identifier.epage188en_HK
dc.identifier.isiWOS:A1997XH82100012-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, EYT=7401994013en_HK
dc.identifier.scopusauthoridLawton, JWM=7102180792en_HK
dc.identifier.scopusauthoridLie, AKW=24284842400en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK

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