File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Effect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man

TitleEffect of atrial natriuretic factor on platelet function in whole blood ex-vivo in man
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1990
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00228/index.htm
Citation
European Journal Of Clinical Pharmacology, 1990, v. 39 n. 6, p. 589-591 How to Cite?
AbstractAtrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol · kg-1 · min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 μg · ml-1)-induced or ADP (0.5-2.0 μM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affected platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperreactivity, often observed in these conditions.
Persistent Identifierhttp://hdl.handle.net/10722/91516
ISSN
2015 Impact Factor: 2.71
2015 SCImago Journal Rankings: 1.096
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLang, CCen_HK
dc.contributor.authorLau, CSen_HK
dc.contributor.authorBelch, JJen_HK
dc.contributor.authorStruthers, ADen_HK
dc.date.accessioned2010-09-17T10:20:40Z-
dc.date.available2010-09-17T10:20:40Z-
dc.date.issued1990en_HK
dc.identifier.citationEuropean Journal Of Clinical Pharmacology, 1990, v. 39 n. 6, p. 589-591en_HK
dc.identifier.issn0031-6970en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91516-
dc.description.abstractAtrial natriuretic factor (ANF) binding sites have been shown to be present on human platelet membranes. We investigated the effect of an infusion of ANF 5 pmol · kg-1 · min-1 on platelet aggregation in whole blood ex-vivo in 8 normal volunteers. Spontaneous platelet aggregation, collagen (0.6-2 μg · ml-1)-induced or ADP (0.5-2.0 μM)-induced aggregation was not affected by ANF. Plasma aldosterone was however significantly attenuated by ANF. These results show that a pharmacological dose of ANF does not affected platelet aggregation in man. These results suggest that the high plasma levels of ANF normally achieved in chronic heart failure or acute myocardial infarction are unlikely to contribute to the platelet hyperreactivity, often observed in these conditions.en_HK
dc.languageengen_HK
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00228/index.htmen_HK
dc.relation.ispartofEuropean Journal of Clinical Pharmacologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAdenosine Diphosphate - pharmacologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAtrial Natriuretic Factor - administration & dosage - pharmacologyen_HK
dc.subject.meshBlood Platelets - drug effects - physiologyen_HK
dc.subject.meshCollagen - pharmacologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfusions, Intravenousen_HK
dc.subject.meshMaleen_HK
dc.subject.meshPlatelet Aggregation - drug effectsen_HK
dc.titleEffect of atrial natriuretic factor on platelet function in whole blood ex-vivo in manen_HK
dc.typeArticleen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/BF00316102en_HK
dc.identifier.pmid2151320en_HK
dc.identifier.scopuseid_2-s2.0-0025649380en_HK
dc.identifier.volume39en_HK
dc.identifier.issue6en_HK
dc.identifier.spage589en_HK
dc.identifier.epage591en_HK
dc.identifier.isiWOS:A1990EN35400015-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLang, CC=7402002432en_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridBelch, JJ=7101752870en_HK
dc.identifier.scopusauthoridStruthers, AD=35427550600en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats