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Article: Plasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension

TitlePlasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertension
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1994
PublisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/
Citation
Journal Of Hypertension, 1994, v. 12 n. 4, p. 449-454 How to Cite?
AbstractObjectives: To study the relationship between hypertension and the plasma levels of brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and to determine whether the plasma levels of BNP and CNP are correlated. Design: A cross-sectional study of the plasma levels of BNP and CNP in hypertensive patients and normotensive controls matched for age and sex was performed. Setting: The hypertension research clinic in a teaching hospital and well-person risk factor screening clinics in general practice health centres. Participants: Fifty-four subjects (29 hypertensive, 25 normotensive controls) took part in the study after giving their informed consent. Hypertensive patients (n = 19) were paired with normotensive controls (n = 19) matched for age and sex to form a subgroup before analysis of the plasma. Methods: The plasma levels of BNP and CNP were determined by specific radioimmunoassays. Results: The mean plasma concentration of BNP was significantly higher in the hypertensive group than in the paired controls. In contrast, the mean plasma concentration of CNP was not significantly different in the hypertensive group than in the paired controls. Multiple regression analysis of all 54 subjects showed that the plasma level of BNP correlated significantly with age and systolic blood pressure, whereas the plasma level of CNP correlated significantly with sex, heart rate and alcohol intake. The CNP levels did not correlate significantly with either systolic or diastolic blood pressure, or with plasma brain natriuretic levels. Conclusions: Hypertension is associated with raised BNP but not CNP plasma levels.
Persistent Identifierhttp://hdl.handle.net/10722/91494
ISSN
2015 Impact Factor: 5.062
2015 SCImago Journal Rankings: 2.193
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, BMen_HK
dc.contributor.authorBrown, MJen_HK
dc.date.accessioned2010-09-17T10:20:19Z-
dc.date.available2010-09-17T10:20:19Z-
dc.date.issued1994en_HK
dc.identifier.citationJournal Of Hypertension, 1994, v. 12 n. 4, p. 449-454en_HK
dc.identifier.issn0263-6352en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91494-
dc.description.abstractObjectives: To study the relationship between hypertension and the plasma levels of brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and to determine whether the plasma levels of BNP and CNP are correlated. Design: A cross-sectional study of the plasma levels of BNP and CNP in hypertensive patients and normotensive controls matched for age and sex was performed. Setting: The hypertension research clinic in a teaching hospital and well-person risk factor screening clinics in general practice health centres. Participants: Fifty-four subjects (29 hypertensive, 25 normotensive controls) took part in the study after giving their informed consent. Hypertensive patients (n = 19) were paired with normotensive controls (n = 19) matched for age and sex to form a subgroup before analysis of the plasma. Methods: The plasma levels of BNP and CNP were determined by specific radioimmunoassays. Results: The mean plasma concentration of BNP was significantly higher in the hypertensive group than in the paired controls. In contrast, the mean plasma concentration of CNP was not significantly different in the hypertensive group than in the paired controls. Multiple regression analysis of all 54 subjects showed that the plasma level of BNP correlated significantly with age and systolic blood pressure, whereas the plasma level of CNP correlated significantly with sex, heart rate and alcohol intake. The CNP levels did not correlate significantly with either systolic or diastolic blood pressure, or with plasma brain natriuretic levels. Conclusions: Hypertension is associated with raised BNP but not CNP plasma levels.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/en_HK
dc.relation.ispartofJournal of Hypertensionen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAging - physiologyen_HK
dc.subject.meshBlood Pressureen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshEpinephrine - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - blood - physiopathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNatriuretic Peptide, Brainen_HK
dc.subject.meshNatriuretic Peptide, C-Typeen_HK
dc.subject.meshNerve Tissue Proteins - blooden_HK
dc.subject.meshNorepinephrine - blooden_HK
dc.subject.meshProteins - metabolismen_HK
dc.subject.meshRadioimmunoassayen_HK
dc.subject.meshReference Valuesen_HK
dc.subject.meshSex Characteristicsen_HK
dc.titlePlasma brain natriuretic peptide and C-type natriuretic peptide in essential hypertensionen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.authorityCheung, BMY=rp1321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid8064169-
dc.identifier.scopuseid_2-s2.0-0028294044en_HK
dc.identifier.volume12en_HK
dc.identifier.issue4en_HK
dc.identifier.spage449en_HK
dc.identifier.epage454en_HK
dc.identifier.isiWOS:A1994NK15500015-
dc.publisher.placeUnited Kingdomen_HK

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