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Article: Macrovascular disease in systemic sclerosis: the tip of an iceberg?

TitleMacrovascular disease in systemic sclerosis: the tip of an iceberg?
Authors
KeywordsAtherosclerosis
Macrovascular Disease
Systemic Sclerosis
Issue Date2008
PublisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/
Citation
Rheumatology (Oxford, England), 2008, v. 47 Suppl 5, p. v16-17 How to Cite?
AbstractThis mini review evaluates mortality in SSc and provides a literature review concluding that premature death does occur in this population. However, there has been a changing spectrum of cause of death over the past three decades, with interstitial lung disease now being the commonest cause of SSc-related mortality. Cardiovascular (CV) mortality and events also contribute to the premature mortality seen in these patients, and this contention is supported by epidemiological studies, and further underpinned by a plethora of increased biomarkers for CV disease and events. Thus, macrovascular disease does occur in these patients, and is likely to contribute to mortality. It remains to be seen whether addressing conventional risk factors will attenuate CV disease in this population.
Persistent Identifierhttp://hdl.handle.net/10722/91482
ISSN
2015 SCImago Journal Rankings: 1.449
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBelch, JJen_HK
dc.contributor.authorMcSwiggan, Sen_HK
dc.contributor.authorLau, Cen_HK
dc.date.accessioned2010-09-17T10:20:08Z-
dc.date.available2010-09-17T10:20:08Z-
dc.date.issued2008en_HK
dc.identifier.citationRheumatology (Oxford, England), 2008, v. 47 Suppl 5, p. v16-17en_HK
dc.identifier.issn1462-0332en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91482-
dc.description.abstractThis mini review evaluates mortality in SSc and provides a literature review concluding that premature death does occur in this population. However, there has been a changing spectrum of cause of death over the past three decades, with interstitial lung disease now being the commonest cause of SSc-related mortality. Cardiovascular (CV) mortality and events also contribute to the premature mortality seen in these patients, and this contention is supported by epidemiological studies, and further underpinned by a plethora of increased biomarkers for CV disease and events. Thus, macrovascular disease does occur in these patients, and is likely to contribute to mortality. It remains to be seen whether addressing conventional risk factors will attenuate CV disease in this population.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/en_HK
dc.relation.ispartofRheumatology (Oxford, England)en_HK
dc.subjectAtherosclerosisen_HK
dc.subjectMacrovascular Diseaseen_HK
dc.subjectSystemic Sclerosisen_HK
dc.subject.meshCardiovascular Diseases - complicationsen_HK
dc.subject.meshCause of Deathen_HK
dc.subject.meshHumansen_HK
dc.subject.meshPulmonary Fibrosis - complications - mortalityen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshScleroderma, Systemic - complications - mortalityen_HK
dc.titleMacrovascular disease in systemic sclerosis: the tip of an iceberg?en_HK
dc.typeArticleen_HK
dc.identifier.emailLau, C:cslau@hku.hken_HK
dc.identifier.authorityLau, C=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/rheumatology/ken280en_HK
dc.identifier.pmid18784129-
dc.identifier.scopuseid_2-s2.0-65849131630en_HK
dc.identifier.scopuseid_2-s2.0-69949163721en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-69949163721&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume47 Suppl 5en_HK
dc.identifier.issueSUPPL. 5en_HK
dc.identifier.spagev16en_HK
dc.identifier.epage17en_HK
dc.identifier.eissn1462-0332-
dc.identifier.isiWOS:000268808700008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridBelch, JJ=7101752870en_HK
dc.identifier.scopusauthoridMcSwiggan, S=8944297300en_HK
dc.identifier.scopusauthoridLau, C=14035682100en_HK

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