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Article: Elevated plasma levels of human adrenomedullin in cardiovascular, respiratory, hepatic and renal disorders

TitleElevated plasma levels of human adrenomedullin in cardiovascular, respiratory, hepatic and renal disorders
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1997
PublisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/
Citation
Clinical Science, 1997, v. 92 n. 1, p. 59-62 How to Cite?
Abstract1. Adrenomedullin is a potent vasodilating peptide first isolated from phaeochromocytoma and adrenal medulla but also found in the heart, lungs and kidneys. It may also be a paracrine factor because endothelial and smooth muscle cells synthesize adrenomedullin as well as express the receptors. Adrenomedullin induces vasorelaxation by activating adenylate cyclase and also by stimulating the release of nitric oxide. 2. We have developed a specific radioimmunoassay and measured the immunoreactivity of human adrenomedullin in the plasma of 58 male subjects: eight with essential hypertension, 12 with heart failure, 10 with ascites due to cirrhosis, 12 with chronic renal failure, four with hypoxia due to chronic obstructive pulmonary disease and 12 control subjects. 3. Plasma levels (mean ± SEM) in patients with essential hypertension (16.3 ± 1.9 pmol/l), congestive heart failure (17.5 ± 2.8 pmol/l) and renal failure (17.7 ± 2.5 pmol/l) were raised compared with control subjects (7.8 ± 1.4 pmol/l, P < 0.05), confirming previous reports. 4. In addition, we observed that plasma levels of adrenomedullin were significantly raised in patients with ascites due to liver cirrhosis (15.5 ± 1.9 pmol/l) and chronic obstructive pulmonary disease with hypoxia (20.0 ± 1.5 pmol/l). 5. We concluded that the plasma level of adrenomedullin is raised in a variety of diseases.
Persistent Identifierhttp://hdl.handle.net/10722/91459
ISSN
2015 Impact Factor: 4.996
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Ben_HK
dc.contributor.authorLeung, Ren_HK
dc.date.accessioned2010-09-17T10:19:45Z-
dc.date.available2010-09-17T10:19:45Z-
dc.date.issued1997en_HK
dc.identifier.citationClinical Science, 1997, v. 92 n. 1, p. 59-62en_HK
dc.identifier.issn0143-5221en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91459-
dc.description.abstract1. Adrenomedullin is a potent vasodilating peptide first isolated from phaeochromocytoma and adrenal medulla but also found in the heart, lungs and kidneys. It may also be a paracrine factor because endothelial and smooth muscle cells synthesize adrenomedullin as well as express the receptors. Adrenomedullin induces vasorelaxation by activating adenylate cyclase and also by stimulating the release of nitric oxide. 2. We have developed a specific radioimmunoassay and measured the immunoreactivity of human adrenomedullin in the plasma of 58 male subjects: eight with essential hypertension, 12 with heart failure, 10 with ascites due to cirrhosis, 12 with chronic renal failure, four with hypoxia due to chronic obstructive pulmonary disease and 12 control subjects. 3. Plasma levels (mean ± SEM) in patients with essential hypertension (16.3 ± 1.9 pmol/l), congestive heart failure (17.5 ± 2.8 pmol/l) and renal failure (17.7 ± 2.5 pmol/l) were raised compared with control subjects (7.8 ± 1.4 pmol/l, P < 0.05), confirming previous reports. 4. In addition, we observed that plasma levels of adrenomedullin were significantly raised in patients with ascites due to liver cirrhosis (15.5 ± 1.9 pmol/l) and chronic obstructive pulmonary disease with hypoxia (20.0 ± 1.5 pmol/l). 5. We concluded that the plasma level of adrenomedullin is raised in a variety of diseases.en_HK
dc.languageengen_HK
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/en_HK
dc.relation.ispartofClinical Scienceen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAdrenomedullinen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnoxia - blooden_HK
dc.subject.meshHeart Failure - blooden_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - blooden_HK
dc.subject.meshKidney Failure, Chronic - blooden_HK
dc.subject.meshLiver Cirrhosis - blooden_HK
dc.subject.meshLung Diseases, Obstructive - blooden_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPeptides - blooden_HK
dc.subject.meshRadioimmunoassayen_HK
dc.subject.meshVasodilator Agentsen_HK
dc.titleElevated plasma levels of human adrenomedullin in cardiovascular, respiratory, hepatic and renal disordersen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, B:mycheung@hku.hken_HK
dc.identifier.authorityCheung, B=rp01321en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9038592-
dc.identifier.scopuseid_2-s2.0-0031023840en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031023840&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume92en_HK
dc.identifier.issue1en_HK
dc.identifier.spage59en_HK
dc.identifier.epage62en_HK
dc.identifier.isiWOS:A1997WC10000008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, B=7103294806en_HK
dc.identifier.scopusauthoridLeung, R=7101876102en_HK

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