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Article: Effects of fish oil on plasma fibrinolysis in patients with mild rheumatoid arthritis

TitleEffects of fish oil on plasma fibrinolysis in patients with mild rheumatoid arthritis
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date1995
PublisherPacini Editore SpA. The Journal's web site is located at http://www.clinexprheumatol.org
Citation
Clinical And Experimental Rheumatology, 1995, v. 13 n. 1, p. 87-90 How to Cite?
AbstractAs rheumatoid arthritis (RA) patients heve been shown to have impaired plasma fibrinolysis and fish oil has been suggested to be useful for RA, this study investigated the effects of fish oil on fibrinolytic parameters in patients with RA. Forty-five RA patients were randomised to receive either fish oil (1.7 gm eicosapentaenoic acid and 1.1 gm docosahexaenoic acid/day) or placebo treatment for at least 6 months. Plasma levels of fibrinogen, tissue-plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) activity were measured at 3-month intervals. In the fish oil treatment group, plasma levels of fibrinogen and t-PA activity were reduced at 6 months when compared with baseline [fibrinogen: 3.2 (2.85-3.53) g/l vs 3.89 (3.56-4.22) g/l, mean (95% confidence intervals for mean), p < 0.02; t-PA activity 1.4 (1.01-1.78) units/ml vs 1.94 (1.55-2.33) units/ml, p < 0.01]. No significant changes in plasma PAI activity were seen during the treatment period in these patients. Placebo treatment did not significantly alter the plasma levels of fibrinogen or t-PA and PAI activity. In conclusion, fish oil supplementation does not appear to produce an improvement in plasma fibrinolysis. Indeed, plasma fibrinogen levels and t-PA activity were reduced. This could be due to an effect of fish oil on acute phase protein production. Alternatively, as t-PA is produced on an 'on demand' basis, its reduction may be related to the lowering of fibrinogen levels following fish oil therapy.
Persistent Identifierhttp://hdl.handle.net/10722/91438
ISSN
2015 Impact Factor: 2.495
2015 SCImago Journal Rankings: 0.953
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, CSen_HK
dc.contributor.authorMcLaren, Men_HK
dc.contributor.authorBelch, JJFen_HK
dc.date.accessioned2010-09-17T10:19:24Z-
dc.date.available2010-09-17T10:19:24Z-
dc.date.issued1995en_HK
dc.identifier.citationClinical And Experimental Rheumatology, 1995, v. 13 n. 1, p. 87-90en_HK
dc.identifier.issn0392-856Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/91438-
dc.description.abstractAs rheumatoid arthritis (RA) patients heve been shown to have impaired plasma fibrinolysis and fish oil has been suggested to be useful for RA, this study investigated the effects of fish oil on fibrinolytic parameters in patients with RA. Forty-five RA patients were randomised to receive either fish oil (1.7 gm eicosapentaenoic acid and 1.1 gm docosahexaenoic acid/day) or placebo treatment for at least 6 months. Plasma levels of fibrinogen, tissue-plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) activity were measured at 3-month intervals. In the fish oil treatment group, plasma levels of fibrinogen and t-PA activity were reduced at 6 months when compared with baseline [fibrinogen: 3.2 (2.85-3.53) g/l vs 3.89 (3.56-4.22) g/l, mean (95% confidence intervals for mean), p < 0.02; t-PA activity 1.4 (1.01-1.78) units/ml vs 1.94 (1.55-2.33) units/ml, p < 0.01]. No significant changes in plasma PAI activity were seen during the treatment period in these patients. Placebo treatment did not significantly alter the plasma levels of fibrinogen or t-PA and PAI activity. In conclusion, fish oil supplementation does not appear to produce an improvement in plasma fibrinolysis. Indeed, plasma fibrinogen levels and t-PA activity were reduced. This could be due to an effect of fish oil on acute phase protein production. Alternatively, as t-PA is produced on an 'on demand' basis, its reduction may be related to the lowering of fibrinogen levels following fish oil therapy.en_HK
dc.languageengen_HK
dc.publisherPacini Editore SpA. The Journal's web site is located at http://www.clinexprheumatol.orgen_HK
dc.relation.ispartofClinical and Experimental Rheumatologyen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshArachidonic Acid - blooden_HK
dc.subject.meshArthritis, Rheumatoid - blooden_HK
dc.subject.meshDocosahexaenoic Acids - blooden_HK
dc.subject.meshEicosapentaenoic Acid - blooden_HK
dc.subject.meshErythrocyte Membrane - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFibrinolysis - drug effectsen_HK
dc.subject.meshFish Oils - pharmacologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPlasminogen Inactivators - blooden_HK
dc.subject.meshTissue Plasminogen Activator - blooden_HK
dc.titleEffects of fish oil on plasma fibrinolysis in patients with mild rheumatoid arthritisen_HK
dc.typeArticleen_HK
dc.identifier.emailLau, CS:cslau@hku.hken_HK
dc.identifier.authorityLau, CS=rp01348en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid7774110-
dc.identifier.scopuseid_2-s2.0-0028902803en_HK
dc.identifier.volume13en_HK
dc.identifier.issue1en_HK
dc.identifier.spage87en_HK
dc.identifier.epage90en_HK
dc.identifier.isiWOS:A1995QN83900015-
dc.publisher.placeItalyen_HK
dc.identifier.scopusauthoridLau, CS=14035682100en_HK
dc.identifier.scopusauthoridMcLaren, M=7005471705en_HK
dc.identifier.scopusauthoridBelch, JJF=7101752870en_HK

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