File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Serial time-encoded amplified imaging for real-time observation of fast dynamic phenomena

TitleSerial time-encoded amplified imaging for real-time observation of fast dynamic phenomena
Authors
KeywordsChemicals And Cas Registry Numbers
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nature
Citation
Nature, 2009, v. 458 n. 7242, p. 1145-1149 How to Cite?
AbstractUltrafast real-time optical imaging is an indispensable tool for studying dynamical events such as shock waves, chemical dynamics in living cells, neural activity, laser surgery and microfluidics. However, conventional CCDs (charge-coupled devices) and their complementary metal-oxide-semiconductor (CMOS) counterparts are incapable of capturing fast dynamical processes with high sensitivity and resolution. This is due in part to a technological limitationit takes time to read out the data from sensor arrays. Also, there is the fundamental compromise between sensitivity and frame rate; at high frame rates, fewer photons are collected during each framea problem that affects nearly all optical imaging systems. Here we report an imaging method that overcomes these limitations and offers frame rates that are at least 1,000 times faster than those of conventional CCDs. Our technique maps a two-dimensional (2D) image into a serial time-domain data stream and simultaneously amplifies the image in the optical domain. We capture an entire 2D image using a single-pixel photodetector and achieve a net image amplification of 25 dB (a factor of 316). This overcomes the compromise between sensitivity and frame rate without resorting to cooling and high-intensity illumination. As a proof of concept, we perform continuous real-time imaging at a frame speed of 163 ns (a frame rate of 6.1 MHz) and a shutter speed of 440 ps. We also demonstrate real-time imaging of microfluidic flow and phase-explosion effects that occur during laser ablation. © 2009 Macmillan Publishers Limited.
Persistent Identifierhttp://hdl.handle.net/10722/91322
ISSN
2015 Impact Factor: 38.138
2015 SCImago Journal Rankings: 21.936
ISI Accession Number ID
Funding AgencyGrant Number
US Defense Advanced Research Projects Agency
Center for Nanoscience Innovation for Defense
Funding Information:

This work was partially supported by the US Defense Advanced Research Projects Agency and the Center for Nanoscience Innovation for Defense. We are grateful to D. R. Solli, Y. Hoshino and T. Kodama for discussions. We also thank T. Lay for creating the animated film.

References

 

DC FieldValueLanguage
dc.contributor.authorGoda, Ken_HK
dc.contributor.authorTsia, KKen_HK
dc.contributor.authorJalali, Ben_HK
dc.date.accessioned2010-09-17T10:17:01Z-
dc.date.available2010-09-17T10:17:01Z-
dc.date.issued2009en_HK
dc.identifier.citationNature, 2009, v. 458 n. 7242, p. 1145-1149en_HK
dc.identifier.issn0028-0836en_HK
dc.identifier.urihttp://hdl.handle.net/10722/91322-
dc.description.abstractUltrafast real-time optical imaging is an indispensable tool for studying dynamical events such as shock waves, chemical dynamics in living cells, neural activity, laser surgery and microfluidics. However, conventional CCDs (charge-coupled devices) and their complementary metal-oxide-semiconductor (CMOS) counterparts are incapable of capturing fast dynamical processes with high sensitivity and resolution. This is due in part to a technological limitationit takes time to read out the data from sensor arrays. Also, there is the fundamental compromise between sensitivity and frame rate; at high frame rates, fewer photons are collected during each framea problem that affects nearly all optical imaging systems. Here we report an imaging method that overcomes these limitations and offers frame rates that are at least 1,000 times faster than those of conventional CCDs. Our technique maps a two-dimensional (2D) image into a serial time-domain data stream and simultaneously amplifies the image in the optical domain. We capture an entire 2D image using a single-pixel photodetector and achieve a net image amplification of 25 dB (a factor of 316). This overcomes the compromise between sensitivity and frame rate without resorting to cooling and high-intensity illumination. As a proof of concept, we perform continuous real-time imaging at a frame speed of 163 ns (a frame rate of 6.1 MHz) and a shutter speed of 440 ps. We also demonstrate real-time imaging of microfluidic flow and phase-explosion effects that occur during laser ablation. © 2009 Macmillan Publishers Limited.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/natureen_HK
dc.relation.ispartofNatureen_HK
dc.subjectChemicals And Cas Registry Numbersen_HK
dc.subject.meshDiagnostic Imaging - instrumentation - methodsen_HK
dc.subject.meshLaser Therapyen_HK
dc.subject.meshMicrofluidicsen_HK
dc.subject.meshMicrospheresen_HK
dc.subject.meshSensitivity and Specificityen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshWateren_HK
dc.titleSerial time-encoded amplified imaging for real-time observation of fast dynamic phenomenaen_HK
dc.typeArticleen_HK
dc.identifier.emailTsia, KK:tsia@hku.hken_HK
dc.identifier.authorityTsia, KK=rp01389en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/nature07980en_HK
dc.identifier.pmid19407796-
dc.identifier.scopuseid_2-s2.0-65949114635en_HK
dc.identifier.hkuros176036-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-65949114635&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume458en_HK
dc.identifier.issue7242en_HK
dc.identifier.spage1145en_HK
dc.identifier.epage1149en_HK
dc.identifier.eissn1476-4687-
dc.identifier.isiWOS:000265754600042-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridGoda, K=35227304100en_HK
dc.identifier.scopusauthoridTsia, KK=6506659574en_HK
dc.identifier.scopusauthoridJalali, B=7004889917en_HK
dc.identifier.citeulike4441407-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats